DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8301 and ZNF805

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_001018857.2	Gene:	ZNF805 / 390980	HGNCID:	23272	Length:	627	Species:	Homo sapiens

Alignment Length:	527	Identity:	131/527 - (24%)
Similarity:	212/527 - (40%)	Gaps:	106/527 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    80 CQEAQLKLSHIYDKIDASSLEDDEIGQEDLEPAEEHQETETTKPTTTVSAETQPNNTA------- 137
            |:.|..:....:.::...:..|.::||...:......:.|..:|......|..|...:
Human    98 CELALSEGISFWGQLTQGASGDSQLGQPKDQDGFSEMQGERLRPGLDSQKEKLPGKMSPKHDGLG 162

  Fly   138 -SDPI--EIFVDAV----DIDEAEEEEEEEEQQQQYDEEVEEPITDESAPPQLTISYACKFCLRP 195
             :|.:  .|..|.|    |:.:.:.....:....|.:|.:                :.|..|
Human   163 TADSVCSRIIQDRVSLGDDVHDCDSHGSGKNPVIQEEENI----------------FKCNEC--- 208

  Fly   196 QENYQLQQLLLEHINASHDPEQPYNCPECEARFQDAASRTVHLKSSHV----EKQHACGVCGKKY 256
            ::.:..::||..| ...|...:||.|.||...|    |::.:|...|:    ||.:.|..|||.:
Human   209 EKVFNKKRLLARH-ERIHSGVKPYECTECGKTF----SKSTYLLQHHMVHTGEKPYKCMECGKAF 268

  Fly   257 GDRHNLRHHVEKYHSETDFECALCEKRFYTRKSLNYHMKWHNPDRQFKCR--------------- 306
            ..:.:|..|...:..|..::|:.|.|.|..|.:...|.:.|..::.|.|:
Human   269 NRKSHLTQHQRIHSGEKPYKCSECGKAFTHRSTFVLHNRSHTGEKPFVCKECGKAFRDRPGFIRH 333

  Fly   307 ---HSG--------CERLFISQRHLMCHEATHSGTSSRKSEHCGFCGKTFIHLKTLRWHIYRQHG 360
               |||        |.::|..:.:||.|:.||:|   .|...|..|||.|.....|..| |..|.
Human   334 YIIHSGENPYECFECGKVFKHRSYLMWHQQTHTG---EKPYECSECGKAFCESAALIHH-YVIHT 394

  Fly   361 GEKPYKCANCTEVF--ASYAEKRIHMLERHRENLTAIERSECMLCRQPFSSEPDLIHHMSAEHLQ 423
            ||||::|..|.:.|  .||       |:||:...|..:...|..|.:.|:.....|.|..|...:
Human   395 GEKPFECLECGKAFNHRSY-------LKRHQRIHTGEKPYVCSECGKAFTHCSTFILHKRAHTGE 452

  Fly   424 RPGAPIIANNKRVLQQKRERQYSGLFQCGSCSQRFNMKSALERHAAVHSEKDRPHACPHCSKRFK 488
            :|                       |:|..|.:.|:.::.|.||.::|: .::|:.|..|.|.|.
Human   453 KP-----------------------FECKECGKAFSNRADLIRHFSIHT-GEKPYECMECGKAFN 493

  Fly   489 RAQDMKWHIKTHEKEKPNVCDVCGKAFALKYVLTQHRLSHEVLEKNFKCNVCGRAYLFEKSLRLH 553
            |...:..|.:.|..|||..|..|||.|.....|.:|.:.| ..||.::|:.||:|:....||..|
Human   494 RRSGLTRHQRIHSGEKPYECIECGKTFCWSTNLIRHSIIH-TGEKPYECSECGKAFSRSSSLTQH 557

  Fly   554 QRTHTGK 560
            ||.|||:
Human   558 QRMHTGR 564

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071	2/6 (33%)
		COG5048	198..>508	CDD:227381	91/341 (27%)
		C2H2 Zn finger	221..241	CDD:275368	6/19 (32%)
		C2H2 Zn finger	249..269	CDD:275368	6/19 (32%)
		C2H2 Zn finger	277..297	CDD:275368	6/19 (32%)
		C2H2 Zn finger	305..327	CDD:275368	9/47 (19%)
		C2H2 Zn finger	338..359	CDD:275368	8/20 (40%)
		C2H2 Zn finger	367..384	CDD:275368	5/18 (28%)
		C2H2 Zn finger	400..420	CDD:275368	5/19 (26%)
		C2H2 Zn finger	451..471	CDD:275368	6/19 (32%)
		C2H2 Zn finger	480..500	CDD:275368	6/19 (32%)
		C2H2 Zn finger	508..528	CDD:275368	7/19 (37%)
		C2H2 Zn finger	537..557	CDD:275368	9/19 (47%)
		C2H2 Zn finger	565..582	CDD:275368
ZNF805	NP_001018857.2	KRAB	13..73	CDD:214630
		KRAB	13..52	CDD:279668
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	71..95
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	113..162		7/48 (15%)
		COG5048	192..568	CDD:227381	117/433 (27%)
		C2H2 Zn finger	205..225	CDD:275368	5/23 (22%)
		zf-H2C2_2	218..241	CDD:290200	9/27 (33%)
		C2H2 Zn finger	233..253	CDD:275368	7/23 (30%)
		zf-H2C2_2	245..270	CDD:290200	8/24 (33%)
		C2H2 Zn finger	261..281	CDD:275368	6/19 (32%)
		zf-H2C2_2	273..298	CDD:290200	7/24 (29%)
		C2H2 Zn finger	289..309	CDD:275368	6/19 (32%)
		zf-H2C2_2	305..324	CDD:290200	4/18 (22%)
		C2H2 Zn finger	317..337	CDD:275368	1/19 (5%)
		zf-C2H2	343..365	CDD:278523	5/21 (24%)
		C2H2 Zn finger	345..365	CDD:275368	5/19 (26%)
		zf-H2C2_2	357..380	CDD:290200	11/25 (44%)
		C2H2 Zn finger	373..393	CDD:275368	8/20 (40%)
		zf-C2H2	399..421	CDD:278523	8/28 (29%)
		C2H2 Zn finger	401..421	CDD:275368	8/26 (31%)
		zf-H2C2_2	413..438	CDD:290200	8/31 (26%)
		C2H2 Zn finger	429..449	CDD:275368	5/19 (26%)
		zf-H2C2_2	445..466	CDD:290200	7/43 (16%)
		C2H2 Zn finger	457..477	CDD:275368	6/19 (32%)
		zf-H2C2_2	469..494	CDD:290200	9/25 (36%)
		C2H2 Zn finger	485..505	CDD:275368	6/19 (32%)
		zf-H2C2_2	498..520	CDD:290200	9/21 (43%)
		C2H2 Zn finger	513..533	CDD:275368	7/19 (37%)
		zf-H2C2_2	525..550	CDD:290200	9/25 (36%)
		C2H2 Zn finger	541..561	CDD:275368	9/19 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100