DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8301 and ZNF324B

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_997278.2	Gene:	ZNF324B / 388569	HGNCID:	33107	Length:	544	Species:	Homo sapiens

Alignment Length:	459	Identity:	120/459 - (26%)
Similarity:	172/459 - (37%)	Gaps:	107/459 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   178 SAPPQLTISYACKFCLRPQENYQ-LQQLLLEHINASHDPEQPYNCPECEARFQDAASRTVHLKSS 241
            |...|.:||......|||.::.: .::...|:......|..|
Human   151 SRSDQASISLRLTSPLRPPKSSRPREKTFTEYRVPGRQPRTP----------------------- 192

  Fly   242 HVEKQHACG--VCGKKYGDRHNLR-----------------HHV-------------EKYHS-ET 273
              |:|..|.  |.|:.:|:..:|:                 |.:             |..|: |.
Human   193 --ERQKPCAQEVPGRAFGNASDLKAASGGRDRRMGAAWQEPHRLLGGQEPSTWDELGEALHAGEK 255

  Fly   274 DFECALCEKRFYTRKSLNYHMKWHNPDRQFKCRHSGCERLFISQRHLMCHEATHSGTSSRKSEHC 338
            .|||..|.|.|.....|..|::.|..:|.::|  :.|.:.|....||..|:..|||.:...   |
Human   256 SFECRACSKVFVKSSDLLKHLRTHTGERPYEC--TQCGKAFSQTSHLTQHQRIHSGETPYA---C 315

  Fly   339 GFCGKTFIHLKTLRWHIYRQHGGEKPYKCANCTEVFASYAEKRIHMLERHRENLTAIERSECMLC 403
            ..|||.|.|..:|..| .|.|..||.::|:.|.:.|:..:.     |.:||:.........|..|
Human   316 PVCGKAFRHSSSLVRH-QRIHTAEKSFRCSECGKAFSHGSN-----LSQHRKIHAGGRPYACAQC 374

  Fly   404 RQPFSSEPDLIHHMSAEHLQRPGAPIIANNKRVLQQKRERQYSG--LFQCGSCSQRFNMKSALER 466
            .:.|.....||.|                         ||.::|  .|.|..|...|:..|:|..
Human   375 GRRFCRNSHLIQH-------------------------ERTHTGEKPFVCALCGAAFSQGSSLFL 414

  Fly   467 HAAVHSEKDRPHACPHCSKRFKRAQDMKWHIKTHEKEKPNVCDVCGKAFALKYVLTQHRLSHEVL 531
            |..||: .::|.||..|.:.|.|:.::..|...|..|:|..|..|||.||...||..||..| ..
Human   415 HQRVHT-GEKPFACAQCGRSFSRSSNLTQHQLLHTGERPFRCVDCGKGFAKGAVLLSHRRIH-TG 477

  Fly   532 EKNFKCNVCGRAYLFEKSLRLHQRTH-TGKTYYKCDLCQ--ERFVTHIKLKTHMQKAHAASQPHS 593
            ||.|.|..||||:....:|..|||.| |.||......|.  ..|     |:.|.:|.....:|..
Human   478 EKPFVCTQCGRAFRERPALLHHQRIHTTEKTNAAAPDCTPGPGF-----LQGHHRKVRRGGKPSP 537

  Fly   594 ADQP 597
            ..:|
Human   538 VLKP 541

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071
		COG5048	198..>508	CDD:227381	79/345 (23%)
		C2H2 Zn finger	221..241	CDD:275368	0/19 (0%)
		C2H2 Zn finger	249..269	CDD:275368	7/51 (14%)
		C2H2 Zn finger	277..297	CDD:275368	6/19 (32%)
		C2H2 Zn finger	305..327	CDD:275368	6/21 (29%)
		C2H2 Zn finger	338..359	CDD:275368	9/20 (45%)
		C2H2 Zn finger	367..384	CDD:275368	3/16 (19%)
		C2H2 Zn finger	400..420	CDD:275368	6/19 (32%)
		C2H2 Zn finger	451..471	CDD:275368	6/19 (32%)
		C2H2 Zn finger	480..500	CDD:275368	5/19 (26%)
		C2H2 Zn finger	508..528	CDD:275368	10/19 (53%)
		C2H2 Zn finger	537..557	CDD:275368	9/19 (47%)
		C2H2 Zn finger	565..582	CDD:275368	3/18 (17%)
ZNF324B	NP_997278.2	KRAB	1..61	CDD:214630
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	184..222		9/62 (15%)
		C2H2 Zn finger	259..279	CDD:275368	6/19 (32%)
		COG5048	<268..499	CDD:227381	79/268 (29%)
		C2H2 Zn finger	287..307	CDD:275368	6/21 (29%)
		C2H2 Zn finger	315..335	CDD:275368	9/20 (45%)
		C2H2 Zn finger	343..363	CDD:275368	6/24 (25%)
		C2H2 Zn finger	371..391	CDD:275368	8/44 (18%)
		C2H2 Zn finger	399..419	CDD:275368	6/19 (32%)
		C2H2 Zn finger	427..447	CDD:275368	5/19 (26%)
		C2H2 Zn finger	455..475	CDD:275368	10/19 (53%)
		C2H2 Zn finger	483..503	CDD:275368	9/19 (47%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	508..544		8/39 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100