DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8301 and ZNF790

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_001229729.1	Gene:	ZNF790 / 388536	HGNCID:	33114	Length:	636	Species:	Homo sapiens

Alignment Length:	565	Identity:	142/565 - (25%)
Similarity:	230/565 - (40%)	Gaps:	96/565 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 KISPNDGLPQKICSDCFTKFCSINAFRLACQEAQLKLSHI--YDKIDASSLEDDEIGQEDLEPAE 113
            |:.|.:|:.::                   :.|||::..|  ...:|......|..|....:..:
Human    86 KLLPKNGIFER-------------------EIAQLEIMRICKNHSLDCLCFRGDWEGNTQFQTLQ 131

  Fly   114 EHQE--------TETTKPT---TTVSAETQPNNTASDPIEI------FVDAVD------IDEAEE 155
            ::||        |...:||   .||....|..||.....|.      |:...|      |..:|:
Human   132 DNQEECFKQVIRTCEKRPTFNQHTVFNLHQRLNTGDKLNEFKELGKAFISGSDHTQHQLIHTSEK 196

  Fly   156 EEEEEEQQQQY--DEEVEEPITDESAPPQLTISYACKFCLRPQENYQLQQLLLEHINASHDPEQP 218
            ...::|....:  |.||.:..|..:...    :|.||.|   .:::.|:..|..| ...|..|:|
Human   197 FCGDKECGNTFLPDSEVIQYQTVHTVKK----TYECKEC---GKSFSLRSSLTGH-KRIHTGEKP 253

  Fly   219 YNCPECEARFQDAASRTVHLKSSHVEKQHACGVCGKKYGDRHNLRHHVEKYHSETDFECALCEKR 283
            :.|.:|...|:..:..:||.:....||.:.|..|||.:....:|..|...:..|..:||..|.|.
Human   254 FKCKDCGKAFRFHSQLSVHKRIHTGEKSYECKECGKAFSCGSDLTRHQRIHTGEKPYECNECRKA 318

  Fly   284 FYTRKSLNYHMKWHNPDRQFKCRHSGCERLFISQRHLMCHEATHSGTSSRKSEHCGFCGKTFIHL 348
            |..|..|..|.:.|..::.::|:.  |.:.|....||..|:..|:|   .||..|..|||.||..
Human   319 FSQRSHLIKHQRIHTGEKPYECKE--CGKAFTRGSHLTQHQRIHTG---EKSHECKECGKAFIRG 378

  Fly   349 KTLRWHIYRQHGGEKPYKCANCTE--VFASYAEKRIHMLERHRENLTAIERSECMLCRQPFSSEP 411
            ..|..| ...|.|.|||||..|.:  :::|:       |.||:...|..:..||..|.:.|:
Human   379 SNLAQH-QNVHVGRKPYKCEKCGKAYIWSSH-------LARHQRIHTGRKPYECKQCGKTFT--- 432

  Fly   412 DLIHHMSAEHLQRPGAPIIANNKRVLQQKRERQYSGLFQCGSCSQRFNMKSALERHAAVHSEKDR 476
                          .|..:|.::::..:::.      ::|..|.:.|...|...||..:|: .:|
Human   433 --------------WASYLAQHEKIHNERKS------YECKECGKTFLHGSEFNRHQKIHT-GER 476

  Fly   477 PHACPHCSKRFKRAQDMKWHIKTHEKEKPNVCDVCGKAFALKYVLTQHRLSHEVLEKNFKCNVCG 541
            .:.|..|.|.|.|..::..|.|.|..::|..|:.|||||.....||:|:..| ..|:.:.|..||
Human   477 NYECKECGKTFFRGSELNRHQKIHTGKRPYECEECGKAFLWGSQLTRHQRMH-TGEEPYVCKECG 540

  Fly   542 RAYLFEKSLRLHQRTHTGKTYYKCDLCQERFVTHIKLKTHMQKAH 586
            :::::...|..|::.||....|.|......|..|.....  ||.|
Human   541 KSFIWGSQLTRHKKIHTDAEPYGCKKSSHIFSHHSYFTE--QKIH 583

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071	6/35 (17%)
		COG5048	198..>508	CDD:227381	83/311 (27%)
		C2H2 Zn finger	221..241	CDD:275368	5/19 (26%)
		C2H2 Zn finger	249..269	CDD:275368	6/19 (32%)
		C2H2 Zn finger	277..297	CDD:275368	7/19 (37%)
		C2H2 Zn finger	305..327	CDD:275368	6/21 (29%)
		C2H2 Zn finger	338..359	CDD:275368	8/20 (40%)
		C2H2 Zn finger	367..384	CDD:275368	3/18 (17%)
		C2H2 Zn finger	400..420	CDD:275368	3/19 (16%)
		C2H2 Zn finger	451..471	CDD:275368	6/19 (32%)
		C2H2 Zn finger	480..500	CDD:275368	7/19 (37%)
		C2H2 Zn finger	508..528	CDD:275368	9/19 (47%)
		C2H2 Zn finger	537..557	CDD:275368	5/19 (26%)
		C2H2 Zn finger	565..582	CDD:275368	3/16 (19%)
ZNF790	NP_001229729.1	KRAB	5..64	CDD:214630
		KRAB	5..44	CDD:279668
		C2H2 Zn finger	145..164	CDD:275368	5/18 (28%)
		C2H2 Zn finger	172..192	CDD:275368	2/19 (11%)
		COG5048	<183..361	CDD:227381	47/187 (25%)
		C2H2 Zn finger	201..220	CDD:275368	5/18 (28%)
		C2H2 Zn finger	228..248	CDD:275368	6/23 (26%)
		zf-H2C2_2	240..263	CDD:290200	7/23 (30%)
		C2H2 Zn finger	256..276	CDD:275368	5/19 (26%)
		zf-H2C2_2	269..293	CDD:290200	8/23 (35%)
		C2H2 Zn finger	284..304	CDD:275368	6/19 (32%)
		zf-H2C2_2	296..321	CDD:290200	8/24 (33%)
		COG5048	308..>575	CDD:227381	84/304 (28%)
		C2H2 Zn finger	312..332	CDD:275368	7/19 (37%)
		zf-H2C2_2	324..349	CDD:290200	6/26 (23%)
		C2H2 Zn finger	340..360	CDD:275368	6/21 (29%)
		zf-H2C2_2	352..377	CDD:290200	12/27 (44%)
		C2H2 Zn finger	368..388	CDD:275368	8/20 (40%)
		C2H2 Zn finger	396..416	CDD:275368	6/26 (23%)
		zf-H2C2_2	408..432	CDD:290200	7/30 (23%)
		C2H2 Zn finger	424..444	CDD:275368	5/36 (14%)
		C2H2 Zn finger	452..472	CDD:275368	6/19 (32%)
		zf-H2C2_2	464..487	CDD:290200	7/23 (30%)
		C2H2 Zn finger	480..500	CDD:275368	7/19 (37%)
		zf-H2C2_2	492..515	CDD:290200	8/22 (36%)
		C2H2 Zn finger	508..528	CDD:275368	9/19 (47%)
		zf-H2C2_2	521..543	CDD:290200	8/22 (36%)
		C2H2 Zn finger	536..556	CDD:275368	5/19 (26%)
		C2H2 Zn finger	564..583	CDD:275368	5/20 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100