DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8301 and Zkscan7

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_001170976.1	Gene:	Zkscan7 / 382118	MGIID:	3040678	Length:	718	Species:	Mus musculus

Alignment Length:	544	Identity:	134/544 - (24%)
Similarity:	212/544 - (38%)	Gaps:	103/544 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    90 IYDKIDASSLEDDEIGQEDLEPAEEHQETETTKPTTT------VSAETQPNNTASDPIEIFVDAV 148
            :.|:...:||..:.||..:..|.::..:...:..|::      ...|....:...||:.
Mouse   232 VRDEHGLASLGKNRIGSSEFSPKQDISKGSHSLDTSSEGLFGVALVERASGDICKDPLA------ 290

  Fly   149 DIDEAEEEEEEEE-----------QQQQYDEEVEEPITDESAPPQLTISYACKFCLRPQENYQLQ 202
               :.||...:||           :.:...|:..|...|....|::..|        |
Mouse   291 ---QREEHPSDEEGSGLESDFLEKEDKNSTEDRNEECKDVGVHPEMPSS--------P------- 337

  Fly   203 QLLLEHINASHDPEQPYNCPECEARFQDAASRTVHLKSSHV-EKQHACGVCGKKYGDRHNLRHHV 266
               :|| ......::.|.|.||...|.. :||.:..:..|| |:...|..|||.:.....|..|:
Mouse   338 ---VEH-QGEAKRQKSYQCDECGKVFSQ-SSRFLGHQRIHVGERPFECNKCGKTFQQISQLVVHL 397

  Fly   267 EKYHSETDFECALCEKRFYTRKSLNYHMKWHNPDRQFKCRHSGCERLFISQRHLMCHEATHSGTS 331
            ..:..|..:||....|.:.....|..|.:..|.|:.:|  .:.|.|..|....|:.|:.||:|..
Mouse   398 RIHTQEKPYECCESGKTYCHSSHLIQHQRLRNGDKPYK--GNECVRASIQSSQLLVHKRTHTGEK 460

  Fly   332 ----------------------SRKSEHCGFCGKTFIHLKTLRWHIYRQHGGEKPYKCANCTEVF 374
                                  |:|...|..|||.|...:.|..| .|.|.|||||:|..|.:.|
Mouse   461 PDESGEAFIWNKSLIQHQVLHISKKLYECNECGKAFYTNRNLIDH-QRIHTGEKPYECIECGKSF 524

  Fly   375 ASYAEKRIHMLERHRENLTAIERSECMLCRQPFSSEPDLIHHMSAEHLQRPGAPIIANNKRVLQQ 439
            :     |...|.||:...|..:..:|..|.:.|.....||.|......::|
Mouse   525 S-----RSKCLTRHQSLHTGEKTYKCSECGKAFLQNSQLIDHKRVHTGEKP-------------- 570

  Fly   440 KRERQYSGLFQCGSCSQRFNMKSALERHAAVHSEKDRPHACPHCSKRFKRAQDMKWHIKTHEKEK 504
                     |:|..|.::|::...|.||..:|: .::|:.|..|.|.|.:...:..|.:.|..||
Mouse   571 ---------FECSECGKKFSLGKCLIRHQRLHT-GEKPYKCSECGKSFNQNSHLIIHQRIHTGEK 625

  Fly   505 PNVCDVCGKAFALKYVLTQHRLSHEVLEKNFKCNVCGRAYLFEKSLRLHQRTHTGKTYYKCDLCQ 569
            |..|:.|||.|:....|..|:.:| ..||.:||..|.:|:.....|.:|||.|||:..|:|..|.
Mouse   626 PYGCNECGKVFSYSSSLMVHQRTH-TGEKPYKCKDCMKAFGDSSQLIVHQRVHTGEKPYECAECG 689

  Fly   570 ERFVTHIKLKTHMQKAHAASQPHS 593
            :.| :......|.|:.|..::|.|
Mouse   690 KAF-SQRSTFNHHQRIHNVAKPSS 712

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071
		COG5048	198..>508	CDD:227381	84/332 (25%)
		C2H2 Zn finger	221..241	CDD:275368	6/19 (32%)
		C2H2 Zn finger	249..269	CDD:275368	6/19 (32%)
		C2H2 Zn finger	277..297	CDD:275368	4/19 (21%)
		C2H2 Zn finger	305..327	CDD:275368	5/21 (24%)
		C2H2 Zn finger	338..359	CDD:275368	8/20 (40%)
		C2H2 Zn finger	367..384	CDD:275368	4/16 (25%)
		C2H2 Zn finger	400..420	CDD:275368	6/19 (32%)
		C2H2 Zn finger	451..471	CDD:275368	6/19 (32%)
		C2H2 Zn finger	480..500	CDD:275368	5/19 (26%)
		C2H2 Zn finger	508..528	CDD:275368	7/19 (37%)
		C2H2 Zn finger	537..557	CDD:275368	7/19 (37%)
		C2H2 Zn finger	565..582	CDD:275368	3/16 (19%)
Zkscan7	NP_001170976.1	SCAN	46..156	CDD:128708
		SCAN	46..133	CDD:280241
		COG5048	333..702	CDD:227381	112/422 (27%)
		C2H2 Zn finger	352..372	CDD:275368	6/20 (30%)
		zf-H2C2_2	368..387	CDD:290200	7/18 (39%)
		C2H2 Zn finger	380..400	CDD:275368	6/19 (32%)
		C2H2 Zn finger	408..427	CDD:275368	4/18 (22%)
		C2H2 Zn finger	437..453	CDD:275368	4/15 (27%)
		zf-C2H2	487..509	CDD:278523	8/22 (36%)
		C2H2 Zn finger	489..509	CDD:275368	8/20 (40%)
		zf-H2C2_2	501..526	CDD:290200	12/30 (40%)
		C2H2 Zn finger	517..537	CDD:275368	7/24 (29%)
		zf-H2C2_2	530..554	CDD:290200	7/23 (30%)
		C2H2 Zn finger	545..565	CDD:275368	6/19 (32%)
		zf-H2C2_2	561..581	CDD:290200	5/42 (12%)
		C2H2 Zn finger	573..593	CDD:275368	6/19 (32%)
		zf-H2C2_2	586..610	CDD:290200	9/24 (38%)
		C2H2 Zn finger	601..621	CDD:275368	5/19 (26%)
		zf-H2C2_2	613..638	CDD:290200	10/24 (42%)
		C2H2 Zn finger	629..649	CDD:275368	7/19 (37%)
		zf-H2C2_2	641..664	CDD:290200	8/23 (35%)
		C2H2 Zn finger	657..677	CDD:275368	7/19 (37%)
		zf-H2C2_2	670..694	CDD:290200	11/24 (46%)
		C2H2 Zn finger	685..705	CDD:275368	5/20 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100