DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8301 and ZNF699

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_940937.1	Gene:	ZNF699 / 374879	HGNCID:	24750	Length:	642	Species:	Homo sapiens

Alignment Length:	562	Identity:	149/562 - (26%)
Similarity:	229/562 - (40%)	Gaps:	111/562 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   106 QEDLEPAE----------EHQETETTKPTTTVSAETQP-----------------NNTASDPIEI 143
            :|||:..:          ||:|...|:..|..|..:|.                 |::....:..
Human    74 EEDLQTVKRELIQGIFMGEHREGFETQLKTNESVASQDICGEKISNEQKIVRFKRNDSWFSSLHE 138

  Fly   144 FVDAVDIDEAEEEEEEEEQQQQYD------EEVEEPITDESAP--PQLTISYACKFCLRPQENYQ 200
            ..::..||...:..|...:....:      ||.::..|....|  ..|..:...|.|    |.::
Human   139 NQESCGIDYQNKSHERHLRNHMVENIYECYEENQDGQTFSQVPNLDSLKRNTEVKSC----ECHE 199

  Fly   201 LQQLLLEHIN-----ASHDPEQPYNCPECEARFQDAASRTVHLKSSHVEKQHACGVCGKKYGDRH 260
            ..:..::|.:     .||...:||.|.||...|...|....|:|:...||.:.|..|.|.:....
Human   200 CGKAFVDHSSLKSHIRSHTGSKPYQCKECGKAFHFLACFKKHMKTPTEEKPYECKECTKAFSCSS 264

  Fly   261 NLRHHVEKYHSETDFECALCEKRFYTRKSLNYHMKWHNPDRQFKCR------------------H 307
            ..|.|::.:..:|::||..|.|.|....||..|.:.|:.|:.::|:                  |
Human   265 FFRAHMKIHIGKTNYECKECGKGFSCSSSLTEHKRIHSGDKPYECKECGKAFSCSSSLSKHKRIH 329

  Fly   308 SG--------CERLFISQRHLMCHEATHSGTSSRKSEHCGFCGKTFIHLKTLRWHIYRQHGGEKP 364
            ||        |.:.|.|..||:.|...|:|   .|...|..|||.|.....|..| .|.|.||||
Human   330 SGDKPYECKECGKAFSSSSHLIIHIRIHTG---EKPYECKECGKAFSESSKLTVH-GRTHTGEKP 390

  Fly   365 YKCANCTEVFASYAEKRIHMLERHRENLTAIERSECMLCRQPFSSEPDLIHHMSAEHLQRPGAPI 429
            |||..|.:.:...:...||| .:|    |..:..||:.|.:.|.....|
Human   391 YKCKECGKAYNCPSSLSIHM-RKH----TGEKPYECLECGKAFYLPTSL---------------- 434

  Fly   430 IANNKRVLQQKRERQYSGLFQCGSCSQRFNMKSALERHAAVHSEKDRPHACPHCSKRFKRAQDMK 494
               |..|..|.||:.|    :|..|.:.|:..|:...|...|:.|.: :.|..|.|.|.|:..:.
Human   435 ---NTHVKNQSREKPY----ECKECGKAFSCPSSFRAHVRDHTGKIQ-YECKECGKTFSRSSSLT 491

  Fly   495 WHIKTHEKEKPNVCDVCGKAFALKYVLTQHRLSHEVLEKNFKCNVCGRAYLFEKSLRLHQRTHTG 559
            .|::||..|||..|..|||||.....||.|..:| ..||.::|..||:|:::..:||:|.|||||
Human   492 EHLRTHSGEKPYECKECGKAFISSSHLTVHIRTH-TGEKPYECKKCGKAFIYPSALRIHMRTHTG 555

  Fly   560 KTYYKCDLCQERFVTHIKLKTHMQKAHAASQPHSADQPLDDL 601
            :..|:|..|.:.|.....|..|       ::.|:.::|.:.|
Human   556 EKPYECKECGKAFRHSSYLTVH-------ARMHTGEKPFECL 590

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071
		COG5048	198..>508	CDD:227381	94/340 (28%)
		C2H2 Zn finger	221..241	CDD:275368	7/19 (37%)
		C2H2 Zn finger	249..269	CDD:275368	5/19 (26%)
		C2H2 Zn finger	277..297	CDD:275368	7/19 (37%)
		C2H2 Zn finger	305..327	CDD:275368	10/47 (21%)
		C2H2 Zn finger	338..359	CDD:275368	8/20 (40%)
		C2H2 Zn finger	367..384	CDD:275368	3/16 (19%)
		C2H2 Zn finger	400..420	CDD:275368	4/19 (21%)
		C2H2 Zn finger	451..471	CDD:275368	5/19 (26%)
		C2H2 Zn finger	480..500	CDD:275368	6/19 (32%)
		C2H2 Zn finger	508..528	CDD:275368	9/19 (47%)
		C2H2 Zn finger	537..557	CDD:275368	8/19 (42%)
		C2H2 Zn finger	565..582	CDD:275368	4/16 (25%)
ZNF699	NP_940937.1	KRAB	19..79	CDD:214630	3/4 (75%)
		KRAB	19..58	CDD:279668
		C2H2 Zn finger	143..159	CDD:275368	3/15 (20%)
		C2H2 Zn finger	167..189	CDD:275368	5/21 (24%)
		COG5048	171..605	CDD:227381	133/465 (29%)
		C2H2 Zn finger	197..217	CDD:275368	1/19 (5%)
		zf-H2C2_2	209..233	CDD:290200	7/23 (30%)
		C2H2 Zn finger	225..245	CDD:275368	7/19 (37%)
		C2H2 Zn finger	253..273	CDD:275368	5/19 (26%)
		C2H2 Zn finger	281..301	CDD:275368	7/19 (37%)
		zf-H2C2_2	293..318	CDD:290200	6/24 (25%)
		C2H2 Zn finger	309..329	CDD:275368	1/19 (5%)
		zf-H2C2_2	321..346	CDD:290200	5/24 (21%)
		C2H2 Zn finger	337..357	CDD:275368	6/19 (32%)
		zf-H2C2_2	349..373	CDD:290200	10/26 (38%)
		C2H2 Zn finger	365..385	CDD:275368	8/20 (40%)
		C2H2 Zn finger	393..413	CDD:275368	5/20 (25%)
		zf-H2C2_2	405..428	CDD:290200	8/27 (30%)
		C2H2 Zn finger	421..439	CDD:275368	5/36 (14%)
		C2H2 Zn finger	449..469	CDD:275368	5/19 (26%)
		zf-C2H2	475..497	CDD:278523	6/21 (29%)
		C2H2 Zn finger	477..497	CDD:275368	6/19 (32%)
		zf-H2C2_2	489..514	CDD:290200	12/24 (50%)
		C2H2 Zn finger	505..525	CDD:275368	9/19 (47%)
		zf-H2C2_2	517..542	CDD:290200	10/25 (40%)
		C2H2 Zn finger	533..553	CDD:275368	8/19 (42%)
		zf-H2C2_2	545..570	CDD:290200	12/24 (50%)
		C2H2 Zn finger	561..581	CDD:275368	5/26 (19%)
		C2H2 Zn finger	589..609	CDD:275368	1/2 (50%)
		zf-H2C2_2	601..626	CDD:290200
		C2H2 Zn finger	617..637	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100