DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8301 and Zfp266

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_001128490.1	Gene:	Zfp266 / 367034	RGDID:	1308643	Length:	604	Species:	Rattus norvegicus

Alignment Length:	664	Identity:	154/664 - (23%)
Similarity:	243/664 - (36%)	Gaps:	200/664 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 NCWPSEMA--QIRLQFA--NWNLKISPNDGLPQKICSDCFTKFCSINAFRLACQ----------- 81
            ||:...:.  .:.::|.  .|.|.......|.:::..:.:....|:     .||
  Rat    35 NCYQDSVTFDDVAVEFTPDEWTLLDLTQKNLYREVMLENYENLTSV-----GCQFFIPSLTPWLK 94

  Fly    82 -----------EAQLKLSHIYDKIDASSLED----------DEIGQEDL-EPAEEHQETE--TTK 122
                       ..||:|.   ..||.|.||:          :.:|...| |.:..|.|.:  .:|
  Rat    95 QEELGVAESALPQQLELQ---PTIDDSELENYFRMQSSSATEMVGDSSLQEQSGNHSEGDLRDSK 156

  Fly   123 PTTTVSAETQPNNTASDPIEIFVDAVDIDEAEEEEEEEEQQQQYDEEVEEPITDESAPPQLTISY 187
            |...|..|....||              :.:.:.:....:...|.:::...:.:.|....::...
  Rat   157 PCGNVLGEQLCLNT--------------EVSTQSQGYSSECNWYGKDILSLLKETSTGQNVSELN 207

  Fly   188 AC--KFCLRPQENYQLQQLLLEHINASHDPEQPYNCPECEARFQDAA------------------ 232
            .|  .|.|.|...|.          ::...|:|:.|.:||..|.:.:
  Rat   208 QCGKLFSLTPNIMYP----------STSTNEKPFECTDCETAFFNQSYFQPDMRPHNGGEPYDWS 262

  Fly   233 ----------SRTVHLKSSHVEKQH------------AC-----GVC-GKKYGD------RHNLR 263
                      |..:||...:....:            ||     |:| |:|:.|      ...:.
  Rat   263 KFGNGFIHPTSLAMHLPILNARNPYKFEECGKDFQYFACLNNPMGMCTGEKFCDCKECWKAFTVS 327

  Fly   264 HHVEKY---HSETDFE-CALCEKRFYTRKSLNYHMKWHNPDRQFKCRHSGCERLFISQRHLMCHE 324
            .|:.:|   |:|...: |.:|.|.|.....|:.|:|.||.::.|.|:.  |.:.|.:..:|..|.
  Rat   328 SHLTQYVSIHTEEKSKVCKICGKSFANYSRLSAHVKTHNEEKPFVCKE--CGKAFKNMSYLNDHV 390

  Fly   325 ATHSGTSSRKSEHCGFCGKTFIHLKTLRWHIYRQHGGEKPYKCANCTEVFASYAEKRIHMLERHR 389
            ..|:|..|.|   |..|||.|:....|..|| |.|.|||||:|..|.:.|:     |...|..|.
  Rat   391 RIHTGIKSYK---CMECGKAFLRWSGLTEHI-RVHTGEKPYECKECGKTFS-----RSTQLTEHI 446

  Fly   390 ENLTAIERSECMLCRQPFSSEPDLIHHMSAEHLQRPGAPIIANNKRVLQQKRERQYSGLFQCGSC 454
            ...|.|:..||..|.:.|:                                   ||||
  Rat   447 RTHTGIKPYECKECGKAFT-----------------------------------QYSG------- 469

  Fly   455 SQRFNMKSALERHAAVHSEKDRPHACPHCSKRFKRAQDMKWHIKTHEKEKPNVCDVCGKAFALKY 519
                     |..|..:|| .::|.||..|.|.|.|...:..|::||..|||..|..|||.|
  Rat   470 ---------LATHVRIHS-GEKPFACKECGKAFTRTSGLIHHVRTHTGEKPFECVHCGKTF---- 520

  Fly   520 VLTQHRLSHEVL---EKNFKCNVCGRAYLFEKSLRLHQRTHTGKTYYKCDLCQERFVTHIKLKTH 581
            :.:.||..|..:   ||.|.||:||:|:::..||.:|.|||||:..|.|..|.:.|..:.:|:.|
  Rat   521 ITSSHRTKHLKIHSGEKPFVCNICGKAFIYSTSLNIHMRTHTGEKPYICKQCGKAFAVYSRLRKH 585

  Fly   582 MQKAHAASQPHSAD 595
             .:.|...:|:..:
  Rat   586 -SRVHTEEKPYQCE 598

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071	11/80 (14%)
		COG5048	198..>508	CDD:227381	88/365 (24%)
		C2H2 Zn finger	221..241	CDD:275368	7/47 (15%)
		C2H2 Zn finger	249..269	CDD:275368	7/31 (23%)
		C2H2 Zn finger	277..297	CDD:275368	7/19 (37%)
		C2H2 Zn finger	305..327	CDD:275368	5/21 (24%)
		C2H2 Zn finger	338..359	CDD:275368	9/20 (45%)
		C2H2 Zn finger	367..384	CDD:275368	4/16 (25%)
		C2H2 Zn finger	400..420	CDD:275368	3/19 (16%)
		C2H2 Zn finger	451..471	CDD:275368	2/19 (11%)
		C2H2 Zn finger	480..500	CDD:275368	6/19 (32%)
		C2H2 Zn finger	508..528	CDD:275368	7/19 (37%)
		C2H2 Zn finger	537..557	CDD:275368	9/19 (47%)
		C2H2 Zn finger	565..582	CDD:275368	4/16 (25%)
Zfp266	NP_001128490.1	KRAB	41..97	CDD:214630	7/60 (12%)
		C2H2 Zn finger	265..281	CDD:275368	3/15 (20%)
		C2H2 Zn finger	289..309	CDD:275368	3/19 (16%)
		C2H2 Zn finger	317..337	CDD:275368	2/19 (11%)
		C2H2 Zn finger	345..365	CDD:275368	7/19 (37%)
		zf-C2H2	371..393	CDD:395048	6/23 (26%)
		C2H2 Zn finger	373..393	CDD:275368	5/21 (24%)
		COG5048	<397..588	CDD:227381	80/256 (31%)
		C2H2 Zn finger	401..421	CDD:275368	9/20 (45%)
		C2H2 Zn finger	429..449	CDD:275368	6/24 (25%)
		C2H2 Zn finger	457..477	CDD:275368	9/70 (13%)
		C2H2 Zn finger	485..505	CDD:275368	6/19 (32%)
		C2H2 Zn finger	513..533	CDD:275368	8/23 (35%)
		C2H2 Zn finger	541..561	CDD:275368	9/19 (47%)
		C2H2 Zn finger	569..589	CDD:275368	5/20 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100