DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8301 and Zfp26

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_001102465.2	Gene:	Zfp26 / 367033	RGDID:	1565847	Length:	956	Species:	Rattus norvegicus

Alignment Length:	701	Identity:	169/701 - (24%)
Similarity:	248/701 - (35%)	Gaps:	230/701 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 CSDCFTKFCSINAFRLACQEAQLKLSHIYDKIDASSLEDDEIGQEDLEPAEEHQETETTKPTTTV 127
            ||||...|  :|...|....:    ||..:.:.    :.:|.||....|.........|:.....
  Rat   288 CSDCGKTF--VNELELQAHSS----SHSENNLH----KPEECGQAFTHPVSHDGHVIPTEKKYYE 342

  Fly   128 SAETQPNNTASDPIEIFVDAVDIDEAEEEEEEEEQQQQYD-EEVEEPITDESAPPQLTI------ 185
            ..:.:...|....:.|.|.:..:            ::.|| :|..:..|:.|:   |.:
  Rat   343 CKKCEKFFTHPVYLNIHVQSHTV------------EKPYDCKECGKAFTERSS---LIVHLRQHT 392

  Fly   186 ---SYACKFC----LRPQENYQLQQLLLEHINASHDPEQPYNCPECEARFQDAASRTVHLKS--- 240
               ||.||.|    ::|..       |.||:. ||..|:||.|.:|...|..::..|.||::
  Rat   393 REKSYECKECGKTFIQPSR-------LTEHMR-SHTGEKPYQCDQCGNAFASSSYLTTHLRTHTG 449

  Fly   241 --------------------SHV-----EKQHACGVCGKKYGDRHNLRHHVEKYHSETDFECALC 280
                                .|:     ||.:.|.||||.:..|..|..|:.|:..|..:.|..|
  Rat   450 EKPFECNICGKAFTRSSYLLGHIRTHTGEKPYECKVCGKAFSGRSWLTIHLRKHTGERPYPCTEC 514

  Fly   281 EKRFYTRKSLNYHMKWHNPDRQFKCR------------------HSG--------CERLFISQRH 319
            ||.|.:...|..|:|.|..::.|:|:                  |:|        |.:.|.::..
  Rat   515 EKAFTSFAQLTEHIKTHTGEKPFRCKVCARTFRNSSCLKTHFRIHTGIKPYKCNYCGKDFTARSG 579

  Fly   320 LMCHEATHSG--------------TSSRKSEH-----------CGFCGKTFIHLKTLRWHIYRQH 359
            |..|...|:|              |||...||           |..|||...|..:|..|: |.|
  Rat   580 LTKHVLIHNGEKPYECKECGKAFSTSSGLVEHIRIHTGEKPFECYQCGKALAHSSSLVGHL-RTH 643

  Fly   360 GGEKPYKCANCTEVFASYAEKRIHM-----------------------LERHRENLTAIERSECM 401
            .||||::|..|.:.|...:..||||                       |.:|....|.....||.
  Rat   644 TGEKPFECNQCDKTFTRSSYLRIHMRTHTGEKPYECKECGKTFPERSCLTKHIRTHTGERPYECK 708

  Fly   402 LCRQPFSSEPDLIHHMSAEHLQRPGAPIIANNKRVLQQKRERQYSGLFQCGSCSQRFNMKSALER 466
            .|.:.|.|...|..|:.....:||                       |||..|::.|...|:||.
  Rat   709 ECGKGFISFAQLTVHIKTHSSERP-----------------------FQCKVCTKSFRNSSSLET 750

  Fly   467 HAAVHS-----------------------------EK--------------------------DR 476
            |..:|:                             ||                          ::
  Rat   751 HFRIHTGVKPYKCSYCGKDFTARSGLTIHLRNHTGEKSYACQECGKAFSTSSGLIAHIRSHKGEK 815

  Fly   477 PHACPHCSKRFKRAQDMKWHIKTHEKEKPNVCDVCGKAFALKYVLTQHRLSHEVLEKNFKCNVCG 541
            |..|.||.|.|..:..:..|:|.|..|||..|.||||.|.....|..|..:| ..||.|:|.:||
  Rat   816 PFECDHCGKAFASSSYLNVHLKIHTGEKPFQCTVCGKTFTCSSYLPVHMRTH-TGEKPFQCIICG 879

  Fly   542 RAYLFEKSLRLHQRTHTGKTYYKCDLCQERFVTHIKLKTHMQKAHAASQPH 592
            :::|:...||:|.|.|||:..|.|..|.:.|..|..|..|::| |...:|:
  Rat   880 KSFLWSSYLRVHMRIHTGEKPYVCQYCGKAFTEHSGLNKHLRK-HTGEKPY 929

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071	7/23 (30%)
		COG5048	198..>508	CDD:227381	107/466 (23%)
		C2H2 Zn finger	221..241	CDD:275368	6/42 (14%)
		C2H2 Zn finger	249..269	CDD:275368	8/19 (42%)
		C2H2 Zn finger	277..297	CDD:275368	8/19 (42%)
		C2H2 Zn finger	305..327	CDD:275368	7/47 (15%)
		C2H2 Zn finger	338..359	CDD:275368	8/20 (40%)
		C2H2 Zn finger	367..384	CDD:275368	5/16 (31%)
		C2H2 Zn finger	400..420	CDD:275368	6/19 (32%)
		C2H2 Zn finger	451..471	CDD:275368	7/19 (37%)
		C2H2 Zn finger	480..500	CDD:275368	7/19 (37%)
		C2H2 Zn finger	508..528	CDD:275368	8/19 (42%)
		C2H2 Zn finger	537..557	CDD:275368	8/19 (42%)
		C2H2 Zn finger	565..582	CDD:275368	5/16 (31%)
Zfp26	NP_001102465.2	KRAB	104..162	CDD:214630
		C2H2 Zn finger	288..308	CDD:275368	7/25 (28%)
		COG5048	338..751	CDD:227381	106/459 (23%)
		C2H2 Zn finger	343..363	CDD:275368	3/19 (16%)
		C2H2 Zn finger	371..391	CDD:275368	4/22 (18%)
		C2H2 Zn finger	399..419	CDD:275368	7/27 (26%)
		C2H2 Zn finger	427..447	CDD:275368	6/19 (32%)
		C2H2 Zn finger	455..475	CDD:275368	1/19 (5%)
		C2H2 Zn finger	483..503	CDD:275368	8/19 (42%)
		C2H2 Zn finger	511..531	CDD:275368	8/19 (42%)
		C2H2 Zn finger	539..559	CDD:275368	1/19 (5%)
		C2H2 Zn finger	567..587	CDD:275368	4/19 (21%)
		COG5048	591..>918	CDD:227381	90/351 (26%)
		C2H2 Zn finger	595..615	CDD:275368	5/19 (26%)
		C2H2 Zn finger	623..643	CDD:275368	8/20 (40%)
		C2H2 Zn finger	651..671	CDD:275368	7/19 (37%)
		C2H2 Zn finger	679..699	CDD:275368	2/19 (11%)
		C2H2 Zn finger	707..727	CDD:275368	6/19 (32%)
		C2H2 Zn finger	735..755	CDD:275368	7/19 (37%)
		C2H2 Zn finger	763..783	CDD:275368	0/19 (0%)
		C2H2 Zn finger	791..811	CDD:275368	0/19 (0%)
		C2H2 Zn finger	819..839	CDD:275368	7/19 (37%)
		C2H2 Zn finger	847..867	CDD:275368	8/19 (42%)
		C2H2 Zn finger	875..895	CDD:275368	8/19 (42%)
		C2H2 Zn finger	903..923	CDD:275368	7/20 (35%)
		C2H2 Zn finger	931..947	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910