DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8301 and Oaz

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_001188929.1	Gene:	Oaz / 36609	FlyBaseID:	FBgn0284250	Length:	1366	Species:	Drosophila melanogaster

Alignment Length:	773	Identity:	153/773 - (19%)
Similarity:	225/773 - (29%)	Gaps:	279/773 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    79 ACQEAQLKLSHIYDKIDASSLEDDE---IGQEDLEPAEEHQETETTKPTTT-----------VSA 129
            ||    |||....|:.:...||..|   .|.||.|..|...|.|.......           |..
  Fly    11 AC----LKLGEKEDEENTGLLEPKEELLSGDEDNEDNEGEDEDEEVADEVAPEGGGGERPQLVPN 71

  Fly   130 ETQPNN--TASDPIEIFVDAVDIDEAEEEEEEEEQQQQYDEEV-----------------EEPIT 175
            |:|..:  ||.:|.   ..|....|.|.||..||.|...||.|                 ||...
  Fly    72 ESQQQSWPTADEPA---APAAVAKEEEAEEGSEELQHPRDEVVASDAAANANGHCKSSGHEEDAV 133

  Fly   176 DESAPPQLTISYACKFCLRPQENY---QLQQL-------LLEHINASHDPE-------------- 216
            |...|..|.:.... ..|...|:|   :||.|       ...|.::|:.|.
  Fly   134 DAEEPEDLELDDEL-LSLSGDEDYDDEELQSLDSFYSDMYSTHTSSSYSPSISDGTMTPNSHHLI 197

  Fly   217 ---------------------------QPYNCPEC-------------------------EARF- 228
                                       :|...|..                         ||:.
  Fly   198 GAPTAAGQEDHPTEGKINGGADGEDLPKPKRLPHFHHHHHHHYHHQQALKIANKLRKINKEAKMG 262

  Fly   229 -------QDAASRTVHLKSSHVEKQ----HACGVCGKKYGDRHNLRHHVEKYHSETDFECALCEK 282
                   ..|||:...|....::.:    :.|..|.|.:.....|:|||:.:.....|:|..|.|
  Fly   263 ATAGGGATGAASKFDKLTGEGIKSRGDGSYQCQFCEKTFPRLGYLKHHVQSHAEHLPFKCEYCSK 327

  Fly   283 RFYTRKSLNYHMKWHNPDRQFKCRHSGCERLFISQRHLMCHEATHSGTSSRKSEHCGFCGKTFIH 347
            .|..::|.:.|.|.|..:|.:||.|  ||..|....||..|..||   ..:|...|..|.:.:..
  Fly   328 LFKHKRSRDRHKKLHTNERNYKCPH--CEAAFSRSDHLKIHMKTH---DIQKPFQCSMCNRGYNT 387

  Fly   348 LKTLRWHIYRQH--------GG--------------------------EKPY------------- 365
            ...|..|:.:..        ||                          ::.|
  Fly   388 AAALTSHMQKHKKNAAILAAGGNPNALNYSPRSTGSASASVSSNGSLQKRRYALALASDSSPSRM 452

  Fly   366 ------------------------KCANCTEV--FASYAEKRIHMLERHREN-----LTAIERSE 399
                                    :|:.|.:|  |:|..:...|:...|.:.     .|.::..|
  Fly   453 DFPKRSRSNHVGGTTTTATPTPLLRCSYCPKVTEFSSLEQLNAHLQSVHEQPQTQAVKTPVQEGE 517

  Fly   400 -----CMLCRQPFSSEPDLIHHMSAEHLQRPGAP------------------------------- 428
                 |..|...|.:...|..||.:.|:.|..:|
  Fly   518 GFQLSCEYCTMKFGNIAGLFQHMRSTHMDRLSSPNSYYEHFNRLATAGTFSPRLALDLPKIKPDL 582

  Fly   429 ----------------IIANNK-RVLQQKRERQY--------SGLFQCGSCSQRFNMKSALERHA 468
                            .::||| |.|....:.|.        .|:|.|..|:.......:...|.
  Fly   583 GSPERESRPAEDDLPTDLSNNKRRPLTPNPQAQTPLAPPSAPPGVFFCNQCNAGLPDFESFRNHL 647

  Fly   469 AVHSEKDRPHACPHCSKRFKRAQDMKWHIKTH---EKEKPNVCDVCGKAFALKYVLTQHRLSHEV 530
            ..|..:.....||||........:.:.|:..|   ...:.|....|||:||....|.||.||..|
  Fly   648 KSHIAEGMQLVCPHCGMSLPEQSEFERHVVGHFLITGSEFNCSSSCGKSFAKSEDLQQHLLSEHV 712

  Fly   531 LEKNFKCNVCGRAYLFEKSLRLHQR-THTGKT-YYKCDLCQERFVTHIKLKTHMQKAH 586
            |.. .||::|........:::||.. .|:.:| ..:|..|.|.|.:..:...|::..|
  Fly   713 LTL-LKCSLCSELCESRMAMQLHLACAHSQETKLLRCSACLELFRSDAEFHVHVKTRH 769

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071	3/7 (43%)
		COG5048	198..>508	CDD:227381	88/539 (16%)
		C2H2 Zn finger	221..241	CDD:275368	7/52 (13%)
		C2H2 Zn finger	249..269	CDD:275368	7/19 (37%)
		C2H2 Zn finger	277..297	CDD:275368	7/19 (37%)
		C2H2 Zn finger	305..327	CDD:275368	8/21 (38%)
		C2H2 Zn finger	338..359	CDD:275368	4/20 (20%)
		C2H2 Zn finger	367..384	CDD:275368	5/18 (28%)
		C2H2 Zn finger	400..420	CDD:275368	6/19 (32%)
		C2H2 Zn finger	451..471	CDD:275368	3/19 (16%)
		C2H2 Zn finger	480..500	CDD:275368	5/19 (26%)
		C2H2 Zn finger	508..528	CDD:275368	9/19 (47%)
		C2H2 Zn finger	537..557	CDD:275368	4/20 (20%)
		C2H2 Zn finger	565..582	CDD:275368	4/16 (25%)
Oaz	NP_001188929.1	C2H2 Zn finger	294..314	CDD:275368	7/19 (37%)
		C2H2 Zn finger	322..342	CDD:275368	7/19 (37%)
		zf-H2C2_2	334..359	CDD:290200	11/26 (42%)
		COG5048	336..769	CDD:227381	84/438 (19%)
		zf-C2H2	348..370	CDD:278523	9/23 (39%)
		C2H2 Zn finger	350..370	CDD:275368	8/21 (38%)
		C2H2 Zn finger	378..398	CDD:275368	4/19 (21%)
		C2H2 Zn finger	630..650	CDD:275368	3/19 (16%)
		C2H2 Zn finger	659..679	CDD:275368	5/19 (26%)
		C2H2 Zn finger	689..707	CDD:275368	7/17 (41%)
		C2H2 Zn finger	1020..1041	CDD:275368
		C2H2 Zn finger	1049..1069	CDD:275368
		C2H2 Zn finger	1197..1217	CDD:275368
		C2H2 Zn finger	1229..1246	CDD:275368
		C2H2 Zn finger	1258..1278	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45449815
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930