DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8301 and Zfp74

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_001258268.1	Gene:	Zfp74 / 365224	RGDID:	1563223	Length:	683	Species:	Rattus norvegicus

Alignment Length:	570	Identity:	158/570 - (27%)
Similarity:	242/570 - (42%)	Gaps:	106/570 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   113 EEHQET------ETTKPT-TTVSAETQPN---NTAS-------------DPIEI----FVDAVDI 150
            :|||:.      :..|.| .|..|:.:|.   ||.|             ||..:    ..|:.|.
  Rat    86 DEHQKNQNRLLRQVLKGTVVTHEADERPKKFANTFSPNSDSVPSGHNLCDPDSVGKRAEPDSGDP 150

  Fly   151 DEAEEEEEEEEQQQQYDEEVEEPITDESAPPQLTISYACKFC-------------LRPQ------ 196
            ..|::...||..|   :::.|:|. ..|:|..:...:.|..|             ||..
  Rat   151 GNAKQPSPEERFQ---EDDAEQPF-HNSSPHFVLTPFKCNHCGKGFSQTLDLIRHLRVHTGGKLY 211

  Fly   197 ------ENYQLQQLLLEHINASHDPEQPYNCPECEARFQDAASRTVHLKSSHVEKQHACGVCGKK 255
                  :.:..::.|:.| :..|..:|.|.|.||...|...::...|.:....||.:.|..|||.
  Rat   212 ECHQCGKGFSHKEKLINH-HKLHSRDQCYECNECGKTFIKMSNLMRHQRIHTGEKPYVCQECGKS 275

  Fly   256 YGDRHNLRHHVEKYHS-ETDFECALCEKRFYTRKSLNYHMKWHNPDRQFKCRHSGCERLFISQRH 319
            :..:.||..| ||.|: |..:||..|.|.|..::||..|.|.|..::.:.|..  |.:.|.....
  Rat   276 FSQKSNLIDH-EKIHTGEKPYECRECGKSFSQKQSLVAHQKVHTGEKPYACNE--CGKAFPRIAS 337

  Fly   320 LMCHEATHSGTSSRKSEHCGFCGKTFIHLKTLRWHIYRQHGGEKPYKCANCTEVFASYAEKRIHM 384
            |..|..:|:|   .|...|..|||.|.....|..|: |.|.|||||:|:.|.:.|:..:...:|
  Rat   338 LALHMRSHTG---EKPYKCDKCGKAFSQFSMLIIHV-RIHTGEKPYECSECGKAFSQSSALTVH- 397

  Fly   385 LERHRENLTAIERSECMLCRQPFSSEPDLIHHMSAEHLQRP------GAPIIANNKRVLQQKRER 443
            :..|    |..:..||..||:.||.:.:.|.|......::|      |...|..:..|   :.:|
  Rat   398 IRSH----TGEKPYECKECRKSFSHKKNFITHQKIHTREKPYGCNECGKAFIQMSNLV---RHQR 455

  Fly   444 QYSG--LFQCGSCSQRFNMKSALERHAAVHSEKDRPHACPHCSKRFKRAQDMKWHIKTHEKEKPN 506
            .::|  .:.|..|.:.|:.||.|..|..:|| .::|:.|..|.|.|.:.|:...|.|.|..|||.
  Rat   456 IHTGEKPYLCKECGKAFSQKSNLIAHEKIHS-GEKPYECNECGKAFSQKQNFITHQKVHTGEKPY 519

  Fly   507 VCDVCGKAFALKYVLTQHRLSHEVLEKNFKCNVCGRAYLFEKSLRLHQRTHTGKTYYKCDLCQER 571
            .|:.|||||:....||.|..|| ..|:.::|:.||:|:.....|.||.|:|||:..|.|:.|.:.
  Rat   520 DCNKCGKAFSQIASLTLHLRSH-TGERPYECDKCGKAFSQCSLLNLHMRSHTGEKPYICNECGKA 583

  Fly   572 FVTHIKLKTHMQKAHAASQP----------------------HSADQPLD 599
            |.....|..|| :.|...:|                      |:.::|.|
  Rat   584 FSQRTSLIVHM-RGHTGEKPYECNKCGKAFSQSSSLTIHIRGHTGEKPFD 632

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071
		COG5048	198..>508	CDD:227381	96/318 (30%)
		C2H2 Zn finger	221..241	CDD:275368	5/19 (26%)
		C2H2 Zn finger	249..269	CDD:275368	8/19 (42%)
		C2H2 Zn finger	277..297	CDD:275368	8/19 (42%)
		C2H2 Zn finger	305..327	CDD:275368	5/21 (24%)
		C2H2 Zn finger	338..359	CDD:275368	8/20 (40%)
		C2H2 Zn finger	367..384	CDD:275368	3/16 (19%)
		C2H2 Zn finger	400..420	CDD:275368	7/19 (37%)
		C2H2 Zn finger	451..471	CDD:275368	7/19 (37%)
		C2H2 Zn finger	480..500	CDD:275368	7/19 (37%)
		C2H2 Zn finger	508..528	CDD:275368	9/19 (47%)
		C2H2 Zn finger	537..557	CDD:275368	8/19 (42%)
		C2H2 Zn finger	565..582	CDD:275368	4/16 (25%)
Zfp74	NP_001258268.1	KRAB	8..68	CDD:214630
		KRAB	8..47	CDD:279668
		C2H2 Zn finger	185..205	CDD:275368	4/19 (21%)
		COG5048	236..677	CDD:227381	128/415 (31%)
		C2H2 Zn finger	241..261	CDD:275368	5/19 (26%)
		zf-H2C2_2	253..278	CDD:290200	7/24 (29%)
		C2H2 Zn finger	269..289	CDD:275368	9/20 (45%)
		zf-H2C2_2	281..306	CDD:290200	12/25 (48%)
		C2H2 Zn finger	297..317	CDD:275368	8/19 (42%)
		zf-H2C2_2	309..332	CDD:290200	7/24 (29%)
		C2H2 Zn finger	325..345	CDD:275368	5/21 (24%)
		zf-H2C2_2	337..362	CDD:290200	10/27 (37%)
		C2H2 Zn finger	353..373	CDD:275368	8/20 (40%)
		zf-H2C2_2	365..390	CDD:290200	12/25 (48%)
		C2H2 Zn finger	381..401	CDD:275368	4/20 (20%)
		zf-H2C2_2	393..418	CDD:290200	8/29 (28%)
		C2H2 Zn finger	409..429	CDD:275368	7/19 (37%)
		C2H2 Zn finger	437..457	CDD:275368	4/22 (18%)
		zf-H2C2_2	449..474	CDD:290200	6/27 (22%)
		C2H2 Zn finger	465..485	CDD:275368	7/19 (37%)
		zf-H2C2_2	477..502	CDD:290200	9/25 (36%)
		C2H2 Zn finger	493..513	CDD:275368	7/19 (37%)
		zf-H2C2_2	505..530	CDD:290200	12/24 (50%)
		C2H2 Zn finger	521..541	CDD:275368	9/19 (47%)
		zf-H2C2_2	533..558	CDD:290200	10/25 (40%)
		C2H2 Zn finger	549..569	CDD:275368	8/19 (42%)
		zf-H2C2_2	562..586	CDD:290200	11/23 (48%)
		C2H2 Zn finger	577..597	CDD:275368	6/20 (30%)
		zf-H2C2_2	589..614	CDD:290200	5/25 (20%)
		C2H2 Zn finger	605..625	CDD:275368	0/19 (0%)
		zf-H2C2_2	617..642	CDD:290200	3/16 (19%)
		C2H2 Zn finger	633..653	CDD:275368	158/570 (28%)
		zf-H2C2_2	645..670	CDD:290200
		C2H2 Zn finger	661..681	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100