DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8301 and Zfp846

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_001128057.1	Gene:	Zfp846 / 363022	RGDID:	1564241	Length:	547	Species:	Rattus norvegicus

Alignment Length:	513	Identity:	147/513 - (28%)
Similarity:	224/513 - (43%)	Gaps:	67/513 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    97 SSLEDDEIGQEDLEPAEEHQETETT-------KPTTTVSAETQPNNTASDPI------EIFVDAV 148
            |.||::::.:|||:..|....|:.:       :..|:...:|..:::|.:..      |||
  Rat    64 SWLEEEDLHREDLQEWEMPLGTQESTLHQDFLRGQTSSGVQTGRSHSARELCYYTQCGEIF---- 124

  Fly   149 DIDEAEEEEEEEEQQQQYDEEVEEPIT----DESAPPQLTISYACKFCLRPQENYQLQQLLLEHI 209
                 .|....:...:.:.......:|    |.||......:|.||.|   .:.:.....|..|:
  Rat   125 -----SEHSYFKTHVKTHSAWNTGHLTHSDHDASAQVHTIKTYPCKIC---GKAFGRSSNLNRHL 181

  Fly   210 NASHDPEQPYNCPECEARFQDAASRTVHLKSSHVEKQHACGVCGKKYGDRHNLRHHVEKYHSETD 274
            . ||..|:||.|.||...|...:....|.::...||.:.|..|||.:..|..|..|:..:.||..
  Rat   182 R-SHTGEKPYECKECGKAFTTYSRLVEHFRTHTGEKPYKCKDCGKAFAKRSGLITHISTHASEKP 245

  Fly   275 FECALCEKRFYTRKSLNYHMKWHNPDRQFKCRHSGCERLFISQRHLMCHEA-THSGTSSRKSEHC 338
            |.|..|.|.|.:...|:.|::.|:.:|.:.|:.  |.|.|::..:|..|.. ||||   .:...|
  Rat   246 FACKECGKAFASSPRLSQHIRIHSGERPYICKE--CGRAFLTSSYLRNHVGRTHSG---ERPYIC 305

  Fly   339 GFCGKTFIHLKTLRWHIYRQHGGEKPYKCANCTEVFASYAEKRIHMLERHRENLTAIERSECMLC 403
            |.|||.|.....||.|: |.|.||:||.|..|.:.|.:.:....|:.:.|...:..|    |..|
  Rat   306 GECGKAFHSYSNLRRHV-RTHSGERPYICKECGKAFLNSSYLHNHIRKTHSGEMPHI----CGEC 365

  Fly   404 RQPFSSEPDLIHHMSAEHLQRPGAPIIANNKRVLQQKRERQYSGLFQCGSCSQRFNMKSALERHA 468
            .:.|.:...|..|:.....:||..                       |..|.:.|...|.|.:|.
  Rat   366 GKVFHASSYLRRHLRTHSGERPCI-----------------------CKECGKAFLNSSYLRKHL 407

  Fly   469 AVHSEKDRPHACPHCSKRFKRAQDMKWHIKTHEKEKPNVCDVCGKAFALKYVLTQHRLSHEVLEK 533
            .:|: .|:|:.|..|.|.::|...:..|:||||.|||..||||||:|.....||:|...| ...|
  Rat   408 TIHT-GDKPYECKDCGKAYRRYNLLHDHLKTHEVEKPFECDVCGKSFQYFSYLTKHIRIH-TGTK 470

  Fly   534 NFKCNVCGRAYLFEKSLRLHQRTHTGKTYYKCDLCQERFVTHIKLKTHMQKAHAASQP 591
            .:||..||:.:....|...|.|||||:..|:|..|::.|.:...|..|: |.||..:|
  Rat   471 PYKCKYCGKDFTTSSSRTEHIRTHTGERPYECMECEKTFTSSSNLIHHV-KIHAREKP 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071
		COG5048	198..>508	CDD:227381	91/310 (29%)
		C2H2 Zn finger	221..241	CDD:275368	5/19 (26%)
		C2H2 Zn finger	249..269	CDD:275368	7/19 (37%)
		C2H2 Zn finger	277..297	CDD:275368	6/19 (32%)
		C2H2 Zn finger	305..327	CDD:275368	6/22 (27%)
		C2H2 Zn finger	338..359	CDD:275368	10/20 (50%)
		C2H2 Zn finger	367..384	CDD:275368	3/16 (19%)
		C2H2 Zn finger	400..420	CDD:275368	5/19 (26%)
		C2H2 Zn finger	451..471	CDD:275368	6/19 (32%)
		C2H2 Zn finger	480..500	CDD:275368	6/19 (32%)
		C2H2 Zn finger	508..528	CDD:275368	10/19 (53%)
		C2H2 Zn finger	537..557	CDD:275368	6/19 (32%)
		C2H2 Zn finger	565..582	CDD:275368	4/16 (25%)
Zfp846	NP_001128057.1	KRAB	14..70	CDD:214630	3/5 (60%)
		KRAB	14..52	CDD:279668
		C2H2 Zn finger	118..137	CDD:275368	4/27 (15%)
		COG5048	160..528	CDD:227381	128/408 (31%)
		zf-C2H2	162..184	CDD:278523	6/25 (24%)
		C2H2 Zn finger	164..184	CDD:275368	5/23 (22%)
		zf-H2C2_2	176..201	CDD:290200	11/25 (44%)
		C2H2 Zn finger	192..212	CDD:275368	5/19 (26%)
		zf-H2C2_2	205..228	CDD:290200	7/22 (32%)
		C2H2 Zn finger	220..240	CDD:275368	7/19 (37%)
		C2H2 Zn finger	248..268	CDD:275368	6/19 (32%)
		C2H2 Zn finger	276..297	CDD:275368	6/22 (27%)
		C2H2 Zn finger	305..325	CDD:275368	10/20 (50%)
		zf-H2C2_2	317..342	CDD:290200	12/25 (48%)
		C2H2 Zn finger	333..354	CDD:275368	4/20 (20%)
		C2H2 Zn finger	362..382	CDD:275368	5/19 (26%)
		zf-H2C2_2	374..399	CDD:290200	7/47 (15%)
		C2H2 Zn finger	390..410	CDD:275368	6/19 (32%)
		zf-H2C2_2	402..427	CDD:290200	8/25 (32%)
		C2H2 Zn finger	418..438	CDD:275368	6/19 (32%)
		C2H2 Zn finger	446..466	CDD:275368	10/19 (53%)
		zf-H2C2_2	458..483	CDD:290200	9/25 (36%)
		C2H2 Zn finger	474..494	CDD:275368	6/19 (32%)
		zf-H2C2_2	489..511	CDD:290200	10/21 (48%)
		C2H2 Zn finger	502..522	CDD:275368	6/20 (30%)
		C2H2 Zn finger	530..547	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100