DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8301 and Zfp870

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_001156534.1	Gene:	Zfp870 / 362845	RGDID:	1597136	Length:	556	Species:	Rattus norvegicus

Alignment Length:	599	Identity:	128/599 - (21%)
Similarity:	212/599 - (35%)	Gaps:	175/599 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 ISPNDGLPQKICSDCFTKFCSINAFRL----------------------ACQEAQL-------KL 87
            :|..:.|.:|:.|....|||..:..|.                      ||:|.::       .|
  Rat    53 VSEYEKLWRKLSSQLVEKFCDYHESRQCAEIFSFNPGHSCPGLATFVKNACEEGRIGHSSLGVPL 117

  Fly    88 SHIYDKIDASSLEDDEIGQ-----EDLEPAEEHQETETTKPTTTVSAETQPNNTASDPIEIFVDA 147
            :|     .....||.|.||     ::|..:......:..|.|.|  .|...||
  Rat   118 NH-----QVGPYEDQEYGQALYERKELGSSSSSLSLQMHKSTPT--GEKPSNN------------ 163

  Fly   148 VDIDEAEEEEEEEEQQQQYDEEVEEPITDESAPPQLTISYACKFCLRPQENYQLQQLLLEHINAS 212
                            :.::|::.                    |::..:.|:          .:
  Rat   164 ----------------KNFEEDLP--------------------CVKSSQMYE----------QN 182

  Fly   213 HDPEQPYNCPECEARFQDAASRTVHLKSSHVEKQHACGVCGKKYGD-----RHN----------- 261
            ...::.|....|...|...:....|.|...|:|.:.|.:|||.:..     ||.
  Rat   183 GCAKKSYMHKACGKGFAHPSPLQRHEKVHSVKKPYVCELCGKGFARLGNLLRHQRTGTGENPFLP 247

  Fly   262 ------------LRHHVEKYHSETDFECALCEKRFYTRKSLNYHMKWHNPDRQFKCRHSGCERLF 314
                        ||..:..:..|..:.|..|.|.|........|.:.|...:.:.|:.  |.:.|
  Rat   248 DPYTRSLPRSACLRRRMSIHAGEKPYVCEQCGKTFLDSTYFRIHRRIHTGVKPYVCKQ--CGKAF 310

  Fly   315 ISQRHLMCHEATHSGTSSRKSEHCGFCGKTFIHLKTLRWHIYRQ----HGGEKPYKCANCTEVFA 375
            .:.|:|..||.||   :..||..|..||..|..     |:.:::    |.|..||.|..|.:.|
  Rat   311 TASRYLKSHELTH---TREKSYVCEQCGSAFTF-----WYQFQKHKVTHSGVNPYVCKQCGKGF- 366

  Fly   376 SYAEKRIHMLERHRENLTAIERSECMLCRQPFSSEPDLIHHMSAEHLQRPGAPIIANNKRVLQQK 440
            :|:..    |:.|....|..:...|..|.:.|.|..:|..|.|....:|
  Rat   367 TYSSS----LKTHERTHTGQKPYVCKHCGKTFGSSGNLKRHGSTHTGER---------------- 411

  Fly   441 RERQYSGLFQCGSCSQRFNMKSALERHAAVHSEKDRPHACPHCSKRFKRAQDMKWHIKTHEKEKP 505
                   |:.|..|.:.||..|:.:.|..:|: .:.|:.|..|.|....:..::.|.:.|..|||
  Rat   412 -------LYVCKQCGKSFNNHSSFQFHNRMHT-GENPYKCKQCGKDLASSSSLQNHERNHSGEKP 468

  Fly   506 NVCDVCGKAFALKYVLTQHRLSHEVLEKNFKCNVCGRAY--LFEKSLRLHQRTHTGKTYYKCDLC 568
            ..|..|||||:....|.:|::.|.. ||.:.|..||:::  .||  :|:|:|.|:.:..|:|:.|
  Rat   469 YACLQCGKAFSSDSSLRKHKIMHSE-EKPYVCKHCGKSFRRFFE--VRVHERIHSSERPYECETC 530

  Fly   569 QERFVTHIKLKTHM 582
            ...|::...|:.|:
  Rat   531 GRGFLSSTHLRRHV 544

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071	11/63 (17%)
		COG5048	198..>508	CDD:227381	75/341 (22%)
		C2H2 Zn finger	221..241	CDD:275368	4/19 (21%)
		C2H2 Zn finger	249..269	CDD:275368	8/47 (17%)
		C2H2 Zn finger	277..297	CDD:275368	5/19 (26%)
		C2H2 Zn finger	305..327	CDD:275368	7/21 (33%)
		C2H2 Zn finger	338..359	CDD:275368	5/24 (21%)
		C2H2 Zn finger	367..384	CDD:275368	4/16 (25%)
		C2H2 Zn finger	400..420	CDD:275368	7/19 (37%)
		C2H2 Zn finger	451..471	CDD:275368	6/19 (32%)
		C2H2 Zn finger	480..500	CDD:275368	4/19 (21%)
		C2H2 Zn finger	508..528	CDD:275368	8/19 (42%)
		C2H2 Zn finger	537..557	CDD:275368	8/21 (38%)
		C2H2 Zn finger	565..582	CDD:275368	4/16 (25%)
Zfp870	NP_001156534.1	KRAB	4..58	CDD:214630	1/4 (25%)
		KRAB	4..43	CDD:279668
		C2H2 Zn finger	194..211	CDD:275368	4/16 (25%)
		zf-H2C2_2	204..228	CDD:290200	8/23 (35%)
		C2H2 Zn finger	219..267	CDD:275368	8/47 (17%)
		Ribosomal_L37ae	<260..321	CDD:302811	15/62 (24%)
		C2H2 Zn finger	275..295	CDD:275368	5/19 (26%)
		zf-H2C2_2	287..311	CDD:290200	4/25 (16%)
		C2H2 Zn finger	303..323	CDD:275368	7/21 (33%)
		C2H2 Zn finger	331..351	CDD:275368	5/24 (21%)
		COG5048	<355..543	CDD:227381	59/219 (27%)
		C2H2 Zn finger	359..379	CDD:275368	6/24 (25%)
		zf-H2C2_2	371..394	CDD:290200	5/26 (19%)
		C2H2 Zn finger	387..407	CDD:275368	7/19 (37%)
		C2H2 Zn finger	415..435	CDD:275368	6/19 (32%)
		C2H2 Zn finger	443..463	CDD:275368	4/19 (21%)
		zf-H2C2_2	455..480	CDD:290200	11/24 (46%)
		C2H2 Zn finger	471..491	CDD:275368	8/19 (42%)
		zf-H2C2_2	483..508	CDD:290200	8/25 (32%)
		C2H2 Zn finger	499..519	CDD:275368	8/21 (38%)
		C2H2 Zn finger	527..547	CDD:275368	5/18 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100