DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8301 and ZBTB41

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_919290.2	Gene:	ZBTB41 / 360023	HGNCID:	24819	Length:	909	Species:	Homo sapiens

Alignment Length:	708	Identity:	167/708 - (23%)
Similarity:	262/708 - (37%)	Gaps:	229/708 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 FLD-------LHHPNCWP--SEMAQIRLQFANWNLKISPNDGLPQ---KICSDCFTKFCSINAFR 77
            |||       |::.|..|  ||:.:          |.||.:.|.:   ::.::...||||    |
Human   164 FLDIIDAVKLLNNENVAPFHSELTE----------KSSPEETLNELTGRLSNNHQCKFCS----R 214

  Fly    78 LACQEAQLKLSHIYD---------------------------------KIDASSLEDDEIGQEDL 109
            ..|.:..|: :|:..                                 |.|.:|  |||  ||..
Human   215 HFCYKKSLE-NHLAKTHRSLLLGKKHGLKMLERSFSARRSKRNRKCPVKFDDTS--DDE--QESG 274

  Fly   110 EPAEEHQETETTKPTTTVSAETQPNNTASDPIEIFVDAVDIDEAEEEEEEEEQQQQY---DEEVE 171
            :.::...:....|       |....|.:.||...:       .|||:|.|||...:|   :|:.|
Human   275 DGSDNLNQENFDK-------EKSDRNDSEDPGSEY-------NAEEDELEEEMSDEYSDIEEQSE 325

  Fly   172 EPITDESAPPQ--------------LTISYACKFCLR-PQENYQLQQL-LLEHINASHDPEQPYN 220
            :...|....|:              :.|..:.|..|: |:.:....:: ..|.....|..|:|:.
Human   326 KDHNDAEEEPEAGDSVGNVHEGLTPVVIQNSNKKILQCPKCDKTFDRIGKYESHTRVHTGEKPFE 390

  Fly   221 CPECEARFQDAASRTVHLK--SSHVE---KQHACGVCGKKYGDRHNLRHHVEKYHSET------- 273
            |..|..|:...::.|||.|  |:..|   |:|.|..|.|.:..:..|..||:::|.|.
Human   391 CDICHQRYSTKSNLTVHRKKHSNETEFHKKEHKCPYCNKLHASKKTLAKHVKRFHPENAQEFISI 455

  Fly   274 ------DFECALCEKRFYTRKSLNYHMKWHNPDRQFKCRHSGCERLFIS---------------- 316
                  .::|.:|:|.|..|..|..||..|:.|:.|||.:  ||..|.|
Human   456 KKTKSESWKCDICKKSFTRRPHLEEHMILHSQDKPFKCTY--CEEHFKSRFARLKHQEKFHLGPF 518

  Fly   317 ---------------QRHLMCHEATHSGTSSRKSEHCGFCGKTFIHLKTLRWHIYRQHGGEKPYK 366
                           :||:.|   ||.|   ::...|..|||:.....||:.|: |.|.||||:.
Human   519 PCDICGRQFNDTGNLKRHIEC---THGG---KRKWTCFICGKSVRERTTLKEHL-RIHSGEKPHL 576

  Fly   367 CANCTEVFASYAEKRIHMLERHRENLTAIERSECMLCRQPFSSEPDLIHHMSAEHLQRPGAPIIA 431
            |:.|.:.|...:..|:|:                            .:||
Human   577 CSICGQSFRHGSSYRLHL----------------------------RVHH--------------- 598

  Fly   432 NNKRVLQQKRERQYSGLFQCGSCSQRFNMKSALERHAAVHSEKDRPHACPHCSKRFKRAQDMKWH 496
            ::||             ::|..|.:.|.....|.:|..:|| .::.|.|..|.|.|.|...:..|
Human   599 DDKR-------------YECDECGKTFIRHDHLTKHKKIHS-GEKAHQCEECGKCFGRRDHLTVH 649

  Fly   497 IKT-HEKEKP--------NVCDVCGKAFALKYVLTQHRLSHEVLEKNFKCNVCGRAYLFEKSLRL 552
            .|: |..||.        :.||||.|.|..|..|..|..:|.. ||.:||.:|.:::..:|:|..
Human   650 YKSVHLGEKVWQKYKATFHQCDVCKKIFKGKSSLEMHFRTHSG-EKPYKCQICNQSFRIKKTLTK 713

  Fly   553 HQRTHTGKTYYKCDLCQERFVTHIKLKTHMQKAHAASQPHSADQPL----DDLINIVI 606
            |...|:....:.|..|...|....|||.|:...|....|   |.||    :.|:::.:
Human   714 HLVIHSDARPFNCQHCNATFKRKDKLKYHIDHVHEIKSP---DDPLSTSEEKLVSLPV 768

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071	19/73 (26%)
		COG5048	198..>508	CDD:227381	86/368 (23%)
		C2H2 Zn finger	221..241	CDD:275368	7/21 (33%)
		C2H2 Zn finger	249..269	CDD:275368	6/19 (32%)
		C2H2 Zn finger	277..297	CDD:275368	8/19 (42%)
		C2H2 Zn finger	305..327	CDD:275368	8/52 (15%)
		C2H2 Zn finger	338..359	CDD:275368	8/20 (40%)
		C2H2 Zn finger	367..384	CDD:275368	4/16 (25%)
		C2H2 Zn finger	400..420	CDD:275368	2/19 (11%)
		C2H2 Zn finger	451..471	CDD:275368	5/19 (26%)
		C2H2 Zn finger	480..500	CDD:275368	7/20 (35%)
		C2H2 Zn finger	508..528	CDD:275368	9/19 (47%)
		C2H2 Zn finger	537..557	CDD:275368	5/19 (26%)
		C2H2 Zn finger	565..582	CDD:275368	6/16 (38%)
ZBTB41	NP_919290.2	BTB_POZ_ZBTB41	66..179	CDD:349535	4/14 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	252..344		25/109 (23%)
		C2H2 Zn finger	363..383	CDD:275368	2/19 (11%)
		C2H2 Zn finger	391..411	CDD:275368	7/19 (37%)
		C2H2 Zn finger	424..442	CDD:275368	5/17 (29%)
		C2H2 Zn finger	465..485	CDD:275368	8/19 (42%)
		C2H2 Zn finger	493..510	CDD:275368	5/18 (28%)
		C2H2 Zn finger	520..541	CDD:275368	3/23 (13%)
		C2H2 Zn finger	549..569	CDD:275368	8/20 (40%)
		C2H2 Zn finger	577..597	CDD:275368	5/47 (11%)
		zf-C2H2	603..625	CDD:395048	5/21 (24%)
		C2H2 Zn finger	605..625	CDD:275368	5/19 (26%)
		C2H2 Zn finger	633..651	CDD:275368	6/17 (35%)
		C2H2 Zn finger	670..687	CDD:275368	8/16 (50%)
		C2H2 Zn finger	698..718	CDD:275368	5/19 (26%)
		C2H2 Zn finger	726..743	CDD:275368	6/16 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S4053
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.950