Protein Alignment CG8301 and ZNF81

DIOPT Version :10

• Sequence 1: NP_649915.1
• Gene: CG8301 / 41160
• FlyBaseID: FBgn0037717
• Length: 607
• Species: Drosophila melanogaster
• Sequence 2: NP_009068.2
• Gene: ZNF81 / 347344
• HGNCID: 13156
• Length: 661
• Species: Homo sapiens
• Alignment Length: 520
• Identity: 132/520 - (25%)
• Similarity: 207/520 - (39%)
• Gaps: 114/520 - (21%)

  Fly    89 HIYDKIDASSLEDDEIGQEDL----EPAEEHQETETTKPTTTVSAETQPNNTASDPIEIFVDAVD 149
            ||::|.:|:...|..||...:    .....|:.|.|                          .|.
Human   206 HIHNKSNAAKNLDKTIGHGQVFTQNSSYSHHENTHT--------------------------GVK 244

  Fly   150 IDEAEEEEEEEEQQQQYDEEVEEPITDES-----------------APPQL-TISYACKFCLRPQ 196
            ..|..:..:....:....:.|:.||.:::                 ||.:: |:.       :|.
Human   245 FCERNQCGKVLSLKHSLSQNVKFPIGEKANTCTEFGKIFTQRSHFFAPQKIHTVE-------KPH 302

  Fly   197 E-----NYQLQQLLLEHINASHDPEQPYNCPECEARFQDAASRTVHLKSSHVEKQHACGVCGKKY 256
            |     |...|:.||......|..|:.|.|.:|...|...:...:|.|:...||.:.|..|||.:
Human   303 ELSKCVNVFTQKPLLSIYLRVHRDEKLYICTKCGKAFIQNSELIMHEKTHTREKPYKCNECGKSF 367

  Fly   257 GDRHNLRHHVEKYHSETDFECALCEKRFYTRKSLNYHMKWHNPDRQFKCRHSGCERLFISQRHLM 321
            ....:|..|...:..|..|||:.|.|.|....:||.|.|.|..:|..||  |.|.:.|..:..|.
Human   368 FQVSSLLRHQTTHTGEKLFECSECGKGFSLNSALNIHQKIHTGERHHKC--SECGKAFTQKSTLR 430

  Fly   322 CHEATHSGTSSRKSEHCGFCGKTFIHLKTLRWHIYRQHGGEKPYKCANCTEVFASYAE----KRI 382
            .|:..|:|   .:|..|..||:.||....|..| .|.|.|||||:|::|.:.|.|.::    |||
Human   431 MHQRIHTG---ERSYICTQCGQAFIQKAHLIAH-QRIHTGEKPYECSDCGKSFPSKSQLQMHKRI 491

  Fly   383 HMLER------------HRENLTAIERSE-------CMLCRQPFSSEPDLIHHMSAEHLQRPGAP 428
            |..|:            :|.||...::|.       |..|.:.|:...:...|.:....::|
Human   492 HTGEKPYICTECGKAFTNRSNLNTHQKSHTGEKSYICAECGKAFTDRSNFNKHQTIHTGEKP--- 553

  Fly   429 IIANNKRVLQQKRERQYSGLFQCGSCSQRFNMKSALERHAAVHSEKDRPHACPHCSKRFKRAQDM 493
                                :.|..|.:.|..||.|..|..:|: .::|:.||.|.|.|.:...:
Human   554 --------------------YVCADCGRAFIQKSELITHQRIHT-TEKPYKCPDCEKSFSKKPHL 597

  Fly   494 KWHIKTHEKEKPNVCDVCGKAFALKYVLTQHRLSHEVLEKNFKCNVCGRAYLFEKSLRLHQRTHT 558
            |.|.:.|..|||.:|..|||||..:....:|:..| ..:|.:||:.||:.:..:..|.:|:..||
Human   598 KVHQRIHTGEKPYICAECGKAFTDRSNFNKHQTIH-TGDKPYKCSDCGKGFTQKSVLSMHRNIHT 661

  Fly   559  558
            Human   662  661

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..88	CDD:462262
		COG5048	198..>508	CDD:227381	95/332 (29%)
		C2H2 Zn finger	221..241	CDD:275368	5/19 (26%)
		C2H2 Zn finger	249..269	CDD:275368	6/19 (32%)
		C2H2 Zn finger	277..297	CDD:275368	8/19 (42%)
		C2H2 Zn finger	305..327	CDD:275368	6/21 (29%)
		C2H2 Zn finger	338..359	CDD:275368	8/20 (40%)
		C2H2 Zn finger	367..384	CDD:275368	7/20 (35%)
		C2H2 Zn finger	400..420	CDD:275368	4/19 (21%)
		C2H2 Zn finger	451..471	CDD:275368	7/19 (37%)
		C2H2 Zn finger	480..500	CDD:275368	7/19 (37%)
		C2H2 Zn finger	508..528	CDD:275368	7/19 (37%)
		SUF4-like	536..>586	CDD:411020	8/23 (35%)
		C2H2 Zn finger	537..558	CDD:411020	5/20 (25%)
		C2H2 Zn finger	537..557	CDD:275368	5/19 (26%)
		C2H2 Zn finger	565..586	CDD:411020
		C2H2 Zn finger	565..582	CDD:275368
ZNF81	NP_009068.2	KRAB	21..81	CDD:214630
		C2H2 Zn finger	249..268	CDD:275368	1/18 (6%)
		C2H2 Zn finger	276..296	CDD:275368	2/19 (11%)
		C2H2 Zn finger	307..324	CDD:275368	4/16 (25%)
		C2H2 Zn finger	332..352	CDD:275368	5/19 (26%)
		COG5048	356..>651	CDD:227381	95/325 (29%)
		C2H2 Zn finger	360..380	CDD:275368	6/19 (32%)
		C2H2 Zn finger	388..408	CDD:275368	8/19 (42%)
		C2H2 Zn finger	416..436	CDD:275368	6/21 (29%)
		C2H2 Zn finger	444..464	CDD:275368	8/20 (40%)
		C2H2 Zn finger	472..492	CDD:275368	6/19 (32%)
		C2H2 Zn finger	500..520	CDD:275368	3/19 (16%)
		C2H2 Zn finger	528..548	CDD:275368	4/19 (21%)
		C2H2 Zn finger	556..576	CDD:275368	7/19 (37%)
		C2H2 Zn finger	584..604	CDD:275368	7/19 (37%)
		C2H2 Zn finger	612..632	CDD:275368	7/19 (37%)
		C2H2 Zn finger	640..660	CDD:275368	5/19 (26%)