DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8301 and ZNF81

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_001365081.1	Gene:	ZNF81 / 347344	HGNCID:	13156	Length:	661	Species:	Homo sapiens

Alignment Length:	520	Identity:	132/520 - (25%)
Similarity:	207/520 - (39%)	Gaps:	114/520 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    89 HIYDKIDASSLEDDEIGQEDL----EPAEEHQETETTKPTTTVSAETQPNNTASDPIEIFVDAVD 149
            ||::|.:|:...|..||...:    .....|:.|.|                          .|.
Human   206 HIHNKSNAAKNLDKTIGHGQVFTQNSSYSHHENTHT--------------------------GVK 244

  Fly   150 IDEAEEEEEEEEQQQQYDEEVEEPITDES-----------------APPQL-TISYACKFCLRPQ 196
            ..|..:..:....:....:.|:.||.:::                 ||.:: |:.       :|.
Human   245 FCERNQCGKVLSLKHSLSQNVKFPIGEKANTCTEFGKIFTQRSHFFAPQKIHTVE-------KPH 302

  Fly   197 E-----NYQLQQLLLEHINASHDPEQPYNCPECEARFQDAASRTVHLKSSHVEKQHACGVCGKKY 256
            |     |...|:.||......|..|:.|.|.:|...|...:...:|.|:...||.:.|..|||.:
Human   303 ELSKCVNVFTQKPLLSIYLRVHRDEKLYICTKCGKAFIQNSELIMHEKTHTREKPYKCNECGKSF 367

  Fly   257 GDRHNLRHHVEKYHSETDFECALCEKRFYTRKSLNYHMKWHNPDRQFKCRHSGCERLFISQRHLM 321
            ....:|..|...:..|..|||:.|.|.|....:||.|.|.|..:|..||  |.|.:.|..:..|.
Human   368 FQVSSLLRHQTTHTGEKLFECSECGKGFSLNSALNIHQKIHTGERHHKC--SECGKAFTQKSTLR 430

  Fly   322 CHEATHSGTSSRKSEHCGFCGKTFIHLKTLRWHIYRQHGGEKPYKCANCTEVFASYAE----KRI 382
            .|:..|:|   .:|..|..||:.||....|..| .|.|.|||||:|::|.:.|.|.::    |||
Human   431 MHQRIHTG---ERSYICTQCGQAFIQKAHLIAH-QRIHTGEKPYECSDCGKSFPSKSQLQMHKRI 491

  Fly   383 HMLER------------HRENLTAIERSE-------CMLCRQPFSSEPDLIHHMSAEHLQRPGAP 428
            |..|:            :|.||...::|.       |..|.:.|:...:...|.:....::|
Human   492 HTGEKPYICTECGKAFTNRSNLNTHQKSHTGEKSYICAECGKAFTDRSNFNKHQTIHTGEKP--- 553

  Fly   429 IIANNKRVLQQKRERQYSGLFQCGSCSQRFNMKSALERHAAVHSEKDRPHACPHCSKRFKRAQDM 493
                                :.|..|.:.|..||.|..|..:|: .::|:.||.|.|.|.:...:
Human   554 --------------------YVCADCGRAFIQKSELITHQRIHT-TEKPYKCPDCEKSFSKKPHL 597

  Fly   494 KWHIKTHEKEKPNVCDVCGKAFALKYVLTQHRLSHEVLEKNFKCNVCGRAYLFEKSLRLHQRTHT 558
            |.|.:.|..|||.:|..|||||..:....:|:..| ..:|.:||:.||:.:..:..|.:|:..||
Human   598 KVHQRIHTGEKPYICAECGKAFTDRSNFNKHQTIH-TGDKPYKCSDCGKGFTQKSVLSMHRNIHT 661

Fly 559 558
Human 662 661

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071
		COG5048	198..>508	CDD:227381	95/332 (29%)
		C2H2 Zn finger	221..241	CDD:275368	5/19 (26%)
		C2H2 Zn finger	249..269	CDD:275368	6/19 (32%)
		C2H2 Zn finger	277..297	CDD:275368	8/19 (42%)
		C2H2 Zn finger	305..327	CDD:275368	6/21 (29%)
		C2H2 Zn finger	338..359	CDD:275368	8/20 (40%)
		C2H2 Zn finger	367..384	CDD:275368	7/20 (35%)
		C2H2 Zn finger	400..420	CDD:275368	4/19 (21%)
		C2H2 Zn finger	451..471	CDD:275368	7/19 (37%)
		C2H2 Zn finger	480..500	CDD:275368	7/19 (37%)
		C2H2 Zn finger	508..528	CDD:275368	7/19 (37%)
		C2H2 Zn finger	537..557	CDD:275368	5/19 (26%)
		C2H2 Zn finger	565..582	CDD:275368
ZNF81	NP_001365081.1	KRAB	21..81	CDD:214630
		C2H2 Zn finger	249..268	CDD:275368	1/18 (6%)
		C2H2 Zn finger	276..296	CDD:275368	2/19 (11%)
		C2H2 Zn finger	307..324	CDD:275368	4/16 (25%)
		C2H2 Zn finger	332..352	CDD:275368	5/19 (26%)
		COG5048	356..>651	CDD:227381	95/325 (29%)
		C2H2 Zn finger	360..380	CDD:275368	6/19 (32%)
		C2H2 Zn finger	388..408	CDD:275368	8/19 (42%)
		C2H2 Zn finger	416..436	CDD:275368	6/21 (29%)
		C2H2 Zn finger	444..464	CDD:275368	8/20 (40%)
		C2H2 Zn finger	472..492	CDD:275368	6/19 (32%)
		C2H2 Zn finger	500..520	CDD:275368	3/19 (16%)
		C2H2 Zn finger	528..548	CDD:275368	4/19 (21%)
		C2H2 Zn finger	556..576	CDD:275368	7/19 (37%)
		C2H2 Zn finger	584..604	CDD:275368	7/19 (37%)
		C2H2 Zn finger	612..632	CDD:275368	7/19 (37%)
		C2H2 Zn finger	640..660	CDD:275368	5/19 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100