DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8301 and ZNF879

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_001129588.1	Gene:	ZNF879 / 345462	HGNCID:	37273	Length:	563	Species:	Homo sapiens

Alignment Length:	409	Identity:	123/409 - (30%)
Similarity:	172/409 - (42%)	Gaps:	59/409 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   187 YACKFCLRPQENYQLQQLLLEHINAS-----HDPEQPYNCPECEARFQDAASRTVHLKSSHVEKQ 246
            |.|..|         .::.|...:.|     |..|:.|.|.||...|..::|.|.||:....||.
Human   204 YKCNIC---------GKIFLHSSSLSKHQRIHTGEKLYKCKECRKAFSQSSSLTQHLRVHTGEKP 259

  Fly   247 HACGVCGKKYGDRHNLRHHVEKYHSETDFECALCEKRFYTRKSLNYHMKWHNPDRQFKCRHSGCE 311
            :.|..|||.:....:|..|...:..|..::|..|.|.|....|||.|.:.|..::.:||..  |.
Human   260 YICSECGKAFSFTTSLIGHQRMHTGERPYKCKECGKTFKGSSSLNNHQRIHTGEKPYKCNE--CG 322

  Fly   312 RLFISQRHLMCHEATHSGTSSRKSEHCGFCGKTFIHLKTLRWHIYRQHGGEKPYKCANCTEVFAS 376
            |.|.....|:.|...|:|   .|...|..|||.|..:..|..| :|.|.||||:.|..|.:||:.
Human   323 RAFSQCSSLIQHHRIHTG---EKPYECTQCGKAFTSISRLSRH-HRIHTGEKPFHCNECGKVFSY 383

  Fly   377 YA----EKRIHMLERHRENLTAIERSECMLCRQPFSSEPDLIHHMSAEHLQRPGAPIIANNKRVL 437
            ::    .:|||         |..:...|..|.:.||....||.|......::|
Human   384 HSALIIHQRIH---------TGEKPYACKECGKAFSQSSALIQHQRIHTGEKP------------ 427

  Fly   438 QQKRERQYSGLFQCGSCSQRFNMKSALERHAAVHSEKDRPHACPHCSKRFKRAQDMKWHIKTHEK 502
                       ::|..|.:.|:..|.|..|..:|: .::|:.|..|.|.|.....:..|.|.|..
Human   428 -----------YKCNECGKAFSWISRLNIHHRIHT-GEKPYNCKECGKAFSSHSGVNTHRKIHTG 480

  Fly   503 EKPNVCDVCGKAFALKYVLTQHRLSHEVLEKNFKCNVCGRAYLFEKSLRLHQRTHTGKTYYKCDL 567
            |||..|:.|.|||.....|.||:..| ..||.:.|.|||:|:....||..|.|.|||:..|||..
Human   481 EKPYKCNDCEKAFNQSSALIQHQRIH-TGEKPYNCKVCGKAFRQSSSLMTHMRIHTGEKPYKCKE 544

  Fly   568 CQERFVTHIKLKTHMQKAH 586
            |.:.|.....|..| |:.|
Human   545 CGKAFSQSSSLTNH-QRTH 562

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071
		COG5048	198..>508	CDD:227381	88/318 (28%)
		C2H2 Zn finger	221..241	CDD:275368	8/19 (42%)
		C2H2 Zn finger	249..269	CDD:275368	6/19 (32%)
		C2H2 Zn finger	277..297	CDD:275368	8/19 (42%)
		C2H2 Zn finger	305..327	CDD:275368	6/21 (29%)
		C2H2 Zn finger	338..359	CDD:275368	8/20 (40%)
		C2H2 Zn finger	367..384	CDD:275368	6/20 (30%)
		C2H2 Zn finger	400..420	CDD:275368	7/19 (37%)
		C2H2 Zn finger	451..471	CDD:275368	6/19 (32%)
		C2H2 Zn finger	480..500	CDD:275368	6/19 (32%)
		C2H2 Zn finger	508..528	CDD:275368	8/19 (42%)
		C2H2 Zn finger	537..557	CDD:275368	9/19 (47%)
		C2H2 Zn finger	565..582	CDD:275368	4/16 (25%)
ZNF879	NP_001129588.1	KRAB	14..74	CDD:214630
		COG5048	202..558	CDD:227381	120/402 (30%)
		C2H2 Zn finger	206..226	CDD:275368	4/28 (14%)
		C2H2 Zn finger	234..254	CDD:275368	8/19 (42%)
		C2H2 Zn finger	262..282	CDD:275368	6/19 (32%)
		C2H2 Zn finger	290..310	CDD:275368	8/19 (42%)
		C2H2 Zn finger	318..338	CDD:275368	6/21 (29%)
		C2H2 Zn finger	346..366	CDD:275368	8/20 (40%)
		C2H2 Zn finger	374..394	CDD:275368	5/19 (26%)
		C2H2 Zn finger	402..422	CDD:275368	7/19 (37%)
		C2H2 Zn finger	430..450	CDD:275368	6/19 (32%)
		C2H2 Zn finger	458..478	CDD:275368	6/19 (32%)
		C2H2 Zn finger	486..506	CDD:275368	8/19 (42%)
		C2H2 Zn finger	514..534	CDD:275368	9/19 (47%)
		C2H2 Zn finger	542..562	CDD:275368	6/20 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100