DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8301 and ZKSCAN2

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_001012999.3	Gene:	ZKSCAN2 / 342357	HGNCID:	25677	Length:	967	Species:	Homo sapiens

Alignment Length:	517	Identity:	130/517 - (25%)
Similarity:	191/517 - (36%)	Gaps:	127/517 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    66 CFTKFCSI-NAFRLACQEAQLKLSHI------YDKIDA-----SSLEDDEIGQEDLEPAEEHQ-- 116
            |.|||.|: .::|      ::|..|:      |.::||     :|.......:|...|:.:.:
Human   550 CRTKFKSLQKSYR------KVKNGHVLESCAFYKEMDALINSRASAPSPSTPEEVPSPSRQERGG 608

  Fly   117 -ETETTKPTTTVSAETQPNNTASDPIEIFVDAVDIDEAEEEEEEEEQQQQYDEEVEEPITDESAP 180
             |.|..:|            |..:|.|...:||..|...|...||       |.|:||  :...|
Human   609 IEVEPQEP------------TGWEPEETSQEAVIEDSCSERMSEE-------EIVQEP--EFQGP 652

  Fly   181 PQLTISYACKFCLRPQENYQLQQLLLEHINASHDPEQ-PYNCPECEARFQDAASRTVHLKSSHVE 244
            |.|         |:...::::...:.|      ||.| .|...|......:.:.|.|...:...:
Human   653 PGL---------LQSPNDFEIGSSIKE------DPTQIVYKDMEQHRALIEKSKRVVSQSTDPSK 702

  Fly   245 -KQHACGVCGKKYGDRHNLRHHVEKYHSETDFECALCEKRFYTRKSLNYHMKWHNPDRQFKCRHS 308
             ::..| :.|:::.:...:|.. :......|...|:..:|.:..|         .|.|..|...|
Human   703 YRKREC-ISGRQWENLQGIRQG-KPMSQPRDLGKAVVHQRPFVGK---------RPYRLLKYGES 756

  Fly   309 GCERLFISQRHLMCHEATHSGTSSRKSEHCGFCGKTFIHLKTLRWHIYRQHGGEKPYKCANCTEV 373
                 |.....||| ..||...:..|   ||.|||.|...::|..| .|.|.||||:||.:|.:.
Human   757 -----FGRSTRLMC-RMTHHKENPYK---CGVCGKCFGRSRSLIRH-QRIHTGEKPFKCLDCGKS 811

  Fly   374 FASY----AEKRIHMLERHRENLTAIERSECMLCRQPFSSEPDLIHHMSAEHLQRPGAPIIANNK 434
            |...    |.:|||         |..:...|..|.:.||....||.|......::|
Human   812 FNDSSNFGAHQRIH---------TGEKPYRCGECGKCFSQSSSLIIHQRTHTGEKP--------- 858

  Fly   435 RVLQQKRERQYSGLFQCGSCSQRFNMKSALERHAAVHSEKDRPHACPHCSKRFKRAQDMKWHIKT 499
                          :|||.|.:.|...|....|..||: .:.|:.|..|.|.|......:.|.:.
Human   859 --------------YQCGECGKSFTNSSHFSAHRRVHT-GENPYKCVDCEKSFNNCTRFREHRRI 908

  Fly   500 HEKEKPNVCDVCGKAFALKYVLTQHRLSHEVLEKNFKCNVCGRAYLFEKSLRLHQRTHTGKT 561
            |..|||..|..|||.|:...|||:||..| |.||...         ...||...:..|.|||
Human   909 HTGEKPYGCAQCGKRFSKSSVLTKHREVH-VREKPLP---------HPPSLYCPENPHKGKT 960

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071	6/21 (29%)
		COG5048	198..>508	CDD:227381	76/315 (24%)
		C2H2 Zn finger	221..241	CDD:275368	3/19 (16%)
		C2H2 Zn finger	249..269	CDD:275368	3/19 (16%)
		C2H2 Zn finger	277..297	CDD:275368	3/19 (16%)
		C2H2 Zn finger	305..327	CDD:275368	5/21 (24%)
		C2H2 Zn finger	338..359	CDD:275368	9/20 (45%)
		C2H2 Zn finger	367..384	CDD:275368	6/20 (30%)
		C2H2 Zn finger	400..420	CDD:275368	7/19 (37%)
		C2H2 Zn finger	451..471	CDD:275368	6/19 (32%)
		C2H2 Zn finger	480..500	CDD:275368	5/19 (26%)
		C2H2 Zn finger	508..528	CDD:275368	10/19 (53%)
		C2H2 Zn finger	537..557	CDD:275368	2/19 (11%)
		C2H2 Zn finger	565..582	CDD:275368
ZKSCAN2	NP_001012999.3	SCAN	41..148	CDD:128708
		SCAN	41..129	CDD:280241
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	150..205
		KRAB_A-box	227..268	CDD:143639
		KRAB	<248..289	CDD:214630
		Myb_DNA-bind_4	340..421	CDD:290549
		Myb_DNA-bind_4	497..578	CDD:290549	9/33 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	586..626		9/51 (18%)
		COG5048	771..>957	CDD:227381	67/232 (29%)
		zf-C2H2	775..797	CDD:278523	10/25 (40%)
		C2H2 Zn finger	777..797	CDD:275368	9/20 (45%)
		zf-H2C2_2	789..813	CDD:290200	11/24 (46%)
		zf-C2H2	803..825	CDD:278523	6/21 (29%)
		C2H2 Zn finger	805..825	CDD:275368	5/19 (26%)
		zf-C2H2	831..853	CDD:278523	7/21 (33%)
		C2H2 Zn finger	833..853	CDD:275368	7/19 (37%)
		zf-H2C2_2	845..870	CDD:290200	9/47 (19%)
		C2H2 Zn finger	861..881	CDD:275368	6/19 (32%)
		zf-H2C2_2	873..898	CDD:290200	8/25 (32%)
		C2H2 Zn finger	889..909	CDD:275368	5/19 (26%)
		zf-H2C2_2	902..925	CDD:290200	9/22 (41%)
		C2H2 Zn finger	917..937	CDD:275368	10/19 (53%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	941..967		7/29 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	62	1.000	Domainoid score	I10319
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910