DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8301 and ZNF774

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_001004309.2	Gene:	ZNF774 / 342132	HGNCID:	33108	Length:	483	Species:	Homo sapiens

Alignment Length:	484	Identity:	129/484 - (26%)
Similarity:	186/484 - (38%)	Gaps:	103/484 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   170 VEEPITDESAPPQLTISYACKFCLRPQENYQLQQ------LLLEHINASHDPEQPYNCPECEARF 228
            :|.|: .|..|.||. .:|.|...||....|.:|      |.|::..|...|.:.:.  :||.:.
Human    16 LENPL-QECHPAQLE-EWALKGISRPSVISQPEQKEEPWVLPLQNFEARKIPRESHT--DCEHQV 76

  Fly   229 ----QD---------AASRTVHLKSSH-------------VEKQHA------------------- 248
                ||         .:|...:...||             :|.||.
Human    77 AKLNQDNSETAEQCGTSSERTNKDLSHTLSWGGNWEQGLELEGQHGTLPGEGQLESFSQERDLNK 141

  Fly   249 -----------CGVCGKKYGDRHNLRHHVEKYHSETDFECALCEKRFYTRKSLNYHMKWHNPDRQ 302
                       |..|||.:.....|..|:..:..|..:.|..|.|.|.....|..|.:.|..::.
Human   142 LLDGYVGEKPMCAECGKSFNQSSYLIRHLRTHTGERPYTCIECGKGFKQSSDLVTHRRTHTGEKP 206

  Fly   303 FKCRHSGCERLFISQRHLMCHEATHSGTSSRKSEHCGFCGKTFIHLKTLRWHIYRQHGGEKPYKC 367
            ::|:  |||:.|.....|:.|:.||:|   .:...|..|||||.....|..| .|.|.|||||.|
Human   207 YQCK--GCEKKFSDSSTLIKHQRTHTG---ERPYECPECGKTFGRKPHLIMH-QRTHTGEKPYAC 265

  Fly   368 ANCTEVFASYAEKRIHMLERHRENLTAIERSECMLCRQPFSSEPDLIHHMSAEHLQRPGAPIIAN 432
            ..|.:.|:     |......|:...|.::...|..|.:.||...|||.|......:||
Human   266 LECHKSFS-----RSSNFITHQRTHTGVKPYRCNDCGESFSQSSDLIKHQRTHTGERP------- 318

  Fly   433 NKRVLQQKRERQYSGLFQCGSCSQRFNMKSALERHAAVHSEKDRPHACPHCSKRFKRAQDMKWHI 497
                            |:|..|.:.|...|....|.:.|| .:||.:||.|.|.|.::..:..|.
Human   319 ----------------FKCPECGKGFRDSSHFVAHMSTHS-GERPFSCPDCHKSFSQSSHLVTHQ 366

  Fly   498 KTHEKEKPNVCDVCGKAFALKYVLTQHRLSHEVLEKNFKCNVCGRAYLFEKSLRLHQRTHTGKTY 562
            :||..|:|..|:.|||.||....|.:|:..| ..|:.:||..||:::........|||.|.|...
Human   367 RTHTGERPFKCENCGKGFADSSALIKHQRIH-TGERPYKCGECGKSFNQSSHFITHQRIHLGDRP 430

  Fly   563 YKCDLCQERFVTHIKLKTHMQKAHAASQP 591
            |:|..|.:.|.......|| |:.|...:|
Human   431 YRCPECGKTFNQRSHFLTH-QRTHTGEKP 458

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071
		COG5048	198..>508	CDD:227381	91/371 (25%)
		C2H2 Zn finger	221..241	CDD:275368	5/32 (16%)
		C2H2 Zn finger	249..269	CDD:275368	6/19 (32%)
		C2H2 Zn finger	277..297	CDD:275368	6/19 (32%)
		C2H2 Zn finger	305..327	CDD:275368	7/21 (33%)
		C2H2 Zn finger	338..359	CDD:275368	9/20 (45%)
		C2H2 Zn finger	367..384	CDD:275368	4/16 (25%)
		C2H2 Zn finger	400..420	CDD:275368	8/19 (42%)
		C2H2 Zn finger	451..471	CDD:275368	5/19 (26%)
		C2H2 Zn finger	480..500	CDD:275368	6/19 (32%)
		C2H2 Zn finger	508..528	CDD:275368	8/19 (42%)
		C2H2 Zn finger	537..557	CDD:275368	6/19 (32%)
		C2H2 Zn finger	565..582	CDD:275368	4/16 (25%)
ZNF774	NP_001004309.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	81..101		3/19 (16%)
		COG5048	152..483	CDD:227381	103/344 (30%)
		C2H2 Zn finger	153..173	CDD:275368	6/19 (32%)
		zf-H2C2_2	165..190	CDD:290200	7/24 (29%)
		C2H2 Zn finger	181..201	CDD:275368	6/19 (32%)
		zf-H2C2_2	193..217	CDD:290200	7/25 (28%)
		C2H2 Zn finger	209..229	CDD:275368	7/21 (33%)
		zf-H2C2_2	222..246	CDD:290200	11/26 (42%)
		C2H2 Zn finger	237..257	CDD:275368	9/20 (45%)
		zf-H2C2_2	249..274	CDD:290200	12/30 (40%)
		C2H2 Zn finger	265..285	CDD:275368	5/24 (21%)
		zf-H2C2_2	277..302	CDD:290200	5/24 (21%)
		zf-C2H2	291..313	CDD:278523	8/21 (38%)
		C2H2 Zn finger	293..313	CDD:275368	8/19 (42%)
		zf-H2C2_2	305..328	CDD:290200	9/45 (20%)
		C2H2 Zn finger	321..341	CDD:275368	5/19 (26%)
		zf-C2H2	347..369	CDD:278523	6/21 (29%)
		C2H2 Zn finger	349..369	CDD:275368	6/19 (32%)
		zf-H2C2_2	361..385	CDD:290200	9/23 (39%)
		C2H2 Zn finger	377..397	CDD:275368	8/19 (42%)
		zf-H2C2_2	389..414	CDD:290200	8/25 (32%)
		C2H2 Zn finger	405..425	CDD:275368	6/19 (32%)
		zf-H2C2_2	417..442	CDD:290200	9/24 (38%)
		zf-C2H2	431..453	CDD:278523	7/22 (32%)
		C2H2 Zn finger	433..453	CDD:275368	6/20 (30%)
		zf-H2C2_2	445..470	CDD:290200	5/15 (33%)
		C2H2 Zn finger	461..481	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100