DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8301 and ZNF260

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_001012774.1	Gene:	ZNF260 / 339324	HGNCID:	13499	Length:	412	Species:	Homo sapiens

Alignment Length:	460	Identity:	131/460 - (28%)
Similarity:	198/460 - (43%)	Gaps:	86/460 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   155 EEEEEEEQQQQYDE--EVEEPITDESAPPQLTISYACKFCLRPQENYQLQQLLLEHINASHDPEQ 217
            |..:.|....|:|:  ..|:|             |.|..|   ::.:.|:|.|:|| ...|..|:
Human     6 ESLQHESDLLQHDQIHTGEKP-------------YECNEC---RKTFSLKQNLVEH-KKMHTGEK 53

  Fly   218 PYNCPECEARFQDAASRTVHLKSSHVEKQHACGVCGKKYGDRHNL----RHHV------------ 266
            .:.|.||.......:|.|:||:|...:|.:.|..|||.:..:.|.    :||.
Human    54 SHECTECGKVCSRVSSLTLHLRSHTGKKAYKCNKCGKAFSQKENFLSHQKHHTGEKPYECEKVSI 118

  Fly   267 --------EKYHSET-DFECALCEKRFYTRKSLNYHMKWHNPDRQFKCRHSGCERLFISQRHLMC 322
                    :|.|:.| .:.|..|.|.|..:..|..|.|.|..::.|:|..  |.|.|..:::|:.
Human   119 QMPTIIRHQKNHTGTKPYACKECGKAFNGKAYLTEHEKIHTGEKPFECNQ--CGRAFSQKQYLIK 181

  Fly   323 HEATHSGTSSRKSEHCGFCGKTFIHLKTLRWHIYRQHGGEKPYKCANCTEVFASYAEKRIHMLER 387
            |:..|:|   :|...|..|||.|...:.|..| .|.|.|||||:|..|.:.|...:.     |.|
Human   182 HQNIHTG---KKPFKCSECGKAFSQKENLIIH-QRIHTGEKPYECKGCGKAFIQKSS-----LIR 237

  Fly   388 HRENLTAIERSECMLCRQPFSSEPDLIHHMSAEHLQRPGAPIIANNKRVLQQKRERQYSGLFQCG 452
            |:.:.|..:...|..|.:.||.:.:|..|......::|                       ::|.
Human   238 HQRSHTGEKPYTCKECGKAFSGKSNLTEHEKIHIGEKP-----------------------YKCN 279

  Fly   453 SCSQRFNMKSALERHAAVHSEKDRPHACPHCSKRFKRAQDMKWHIKTHEKEKPNVCDVCGKAFAL 517
            .|...|..|..|.:|..:|: .::|:.|..|.|.|.|...:..|::.|..:||..|.||||||..
Human   280 ECGTIFRQKQYLIKHHNIHT-GEKPYECNKCGKAFSRITSLIVHVRIHTGDKPYECKVCGKAFCQ 343

  Fly   518 KYVLTQHRLSHEVLEKNFKCNVCGRAYLFEKSLRLHQRTHTGKTYYKCDLCQERF------VTHI 576
            ...||.|..|| ..||.:.||.||:|:....:|.||.|.|||:..|:|..|.:.|      :.|.
Human   344 SSSLTVHMRSH-TGEKPYGCNECGKAFSQFSTLALHMRIHTGEKPYQCSECGKAFSQKSHHIRHQ 407

  Fly   577 KLKTH 581
            ::.||
Human   408 RIHTH 412

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071
		COG5048	198..>508	CDD:227381	89/334 (27%)
		C2H2 Zn finger	221..241	CDD:275368	7/19 (37%)
		C2H2 Zn finger	249..269	CDD:275368	7/43 (16%)
		C2H2 Zn finger	277..297	CDD:275368	7/19 (37%)
		C2H2 Zn finger	305..327	CDD:275368	6/21 (29%)
		C2H2 Zn finger	338..359	CDD:275368	8/20 (40%)
		C2H2 Zn finger	367..384	CDD:275368	3/16 (19%)
		C2H2 Zn finger	400..420	CDD:275368	6/19 (32%)
		C2H2 Zn finger	451..471	CDD:275368	6/19 (32%)
		C2H2 Zn finger	480..500	CDD:275368	6/19 (32%)
		C2H2 Zn finger	508..528	CDD:275368	10/19 (53%)
		C2H2 Zn finger	537..557	CDD:275368	9/19 (47%)
		C2H2 Zn finger	565..582	CDD:275368	6/23 (26%)
ZNF260	NP_001012774.1	COG5048	25..406	CDD:227381	123/433 (28%)
		C2H2 Zn finger	29..49	CDD:275368	7/23 (30%)
		C2H2 Zn finger	57..77	CDD:275368	7/19 (37%)
		C2H2 Zn finger	85..130	CDD:275368	8/44 (18%)
		C2H2 Zn finger	138..158	CDD:275368	7/19 (37%)
		C2H2 Zn finger	166..186	CDD:275368	6/21 (29%)
		C2H2 Zn finger	194..214	CDD:275368	8/20 (40%)
		C2H2 Zn finger	222..242	CDD:275368	6/24 (25%)
		C2H2 Zn finger	250..270	CDD:275368	6/19 (32%)
		C2H2 Zn finger	278..298	CDD:275368	6/19 (32%)
		C2H2 Zn finger	306..326	CDD:275368	6/19 (32%)
		C2H2 Zn finger	334..354	CDD:275368	10/19 (53%)
		C2H2 Zn finger	362..382	CDD:275368	9/19 (47%)
		C2H2 Zn finger	390..410	CDD:275368	4/19 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100