DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8301 and CG17612

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_608824.1	Gene:	CG17612 / 33639	FlyBaseID:	FBgn0031597	Length:	618	Species:	Drosophila melanogaster

Alignment Length:	658	Identity:	142/658 - (21%)
Similarity:	228/658 - (34%)	Gaps:	195/658 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 LKISPNDGLPQKICSDCF------TKF----------------CSINAFRLACQEAQLKLSHIYD 92
            |.:.....||:.:|..|.      ||.                .|||.      |..|....:|.
  Fly    14 LSVKRGGSLPKTLCLQCLHMDTFGTKHKGPRPETQINDKVHLEMSING------EDGLPEHPLYP 72

  Fly    93 KIDASSLEDDE-IGQEDLEPAEEHQETETTKPTTTVSAETQPNNTASDPIEIFVDAV-------- 148
            ::.....|:|. |.::.:|....|.| |....:..|..|...|:.|::.:.:..|:.
  Fly    73 EVQLVVKEEDALIKKKVIEENHIHNE-EIIGASNIVDVEVHENHRANNDVILIQDSFAEEVILED 136

  Fly   149 -----DI----DEAEEEE---------EEEEQQQQY---DEEVEEPITDESAPPQLTISYACKFC 192
                 |:    |...|||         |.|:.|.:|   .|.:|||...           :|:.|
  Fly   137 HPANNDVIIIQDSVAEEELPVIKEEAIEGEDLQGEYFIITECLEEPAIG-----------SCRVC 190

  Fly   193 LRPQEN------------YQLQQLLLEHIN---ASHDPEQPYNCPEC----EARFQDAASR---- 234
            |...:|            ..:..:|.::..   ...|....|.|..|    :..|.|..|:
  Fly   191 LEQSDNLTNIFDDAHQYGIPIATILSQYTGMPVEKGDSFSEYICVTCLDVVKNAFDDLESKENTI 255

  Fly   235 --------------TVHLKSSHVEKQ------HACGVCGKKYGDRHNLRHHVEKYHSET------ 273
                          ::.:|:..|:.:      |.|..|.|.:.....|:.|: :.|:||
  Fly   256 QMYRQPKEEIIDIDSIPVKNKPVDYEVTGKPPHRCPQCPKIFLLAAKLQAHI-RTHNETRTTEPP 319

  Fly   274 DFECALCEKRFYTRKSLNYHMKWH--NPDRQ------FKCRHSGCERLFISQRHLMCHEATHSGT 330
            ..:|.:|...:..|..|..||..|  :.:|:      ::|.|  |.:||:....|..|..||...
  Fly   320 RLKCPMCPSIYMKRGCLEAHMWIHRASDERESELEPPYRCPH--CPKLFLYSSFLEIHIQTHEDV 382

  Fly   331 S---SRKSEH-CGFCGKTFIHLKTLRWHIYRQHGGEKPYKCANCTEVFASYAEKRIHMLERHREN 391
            |   ||||.| |..|...|..:.:|:.|: :.|.||:.:||..|...|...:..:.|.
  Fly   383 SQRLSRKSSHKCAQCADVFSDVSSLKDHV-KIHAGERTFKCPLCLMSFQEESNLKSHD------- 439

  Fly   392 LTAIERSECMLCRQPFSSEPDLIHHMSAEHLQRPGAPIIANNKRVLQQKRERQYSGLFQCGSCSQ 456
             .|..|.:|..|.:.|.|:..|..|....|..:                      |.|:|..|.|
  Fly   440 -CAHTRFKCHKCSKFFESQNYLDFHFKKSHTTK----------------------GPFKCIKCQQ 481

  Fly   457 RFNMKSALERHAAVH--------SEKDRPHACPHCSKRFKRAQDMKWHIKTHEKEKPNV----CD 509
            .|..::.|:.|.:..        ....:...||.|.|:|....:.:.|..||:|.|..:    |.
  Fly   482 TFQKRNGLKEHISSQVCVQFLRSKSPGQIFPCPKCPKKFSIEDNYQMHHATHKKVKTVIERHNCT 546

  Fly   510 VCGKAFALKYVLTQHRLSHEVLEKNFKCNVCGRAYLFEKSLRLHQ------------RTHTGKTY 562
            .|.|::..|.:||:|.|||.      :|..|..::..:..|..|.            |.:....|
  Fly   547 QCKKSYQNKKLLTKHILSHN------RCVHCSMSFTSKYLLEQHTCSQSYQLNGSRGRKNPNLNY 605

  Fly   563 YKCDLCQE 570
            .:|:...|
  Fly   606 NECEESNE 613

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071	12/58 (21%)
		COG5048	198..>508	CDD:227381	83/382 (22%)
		C2H2 Zn finger	221..241	CDD:275368	6/41 (15%)
		C2H2 Zn finger	249..269	CDD:275368	5/19 (26%)
		C2H2 Zn finger	277..297	CDD:275368	6/19 (32%)
		C2H2 Zn finger	305..327	CDD:275368	7/21 (33%)
		C2H2 Zn finger	338..359	CDD:275368	5/20 (25%)
		C2H2 Zn finger	367..384	CDD:275368	3/16 (19%)
		C2H2 Zn finger	400..420	CDD:275368	6/19 (32%)
		C2H2 Zn finger	451..471	CDD:275368	6/19 (32%)
		C2H2 Zn finger	480..500	CDD:275368	6/19 (32%)
		C2H2 Zn finger	508..528	CDD:275368	8/19 (42%)
		C2H2 Zn finger	537..557	CDD:275368	5/31 (16%)
		C2H2 Zn finger	565..582	CDD:275368	2/6 (33%)
CG17612	NP_608824.1	zf-AD	187..>246	CDD:285071	9/58 (16%)
		C2H2 Zn finger	290..310	CDD:275368	5/20 (25%)
		C2H2 Zn finger	323..343	CDD:275370	6/19 (32%)
		zf-C2H2_8	356..438	CDD:292531	27/84 (32%)
		C2H2 Zn finger	359..379	CDD:275368	7/21 (33%)
		C2H2 Zn finger	394..414	CDD:275368	5/20 (25%)
		C2H2 Zn finger	422..438	CDD:275368	3/15 (20%)
		C2H2 Zn finger	447..463	CDD:275368	5/15 (33%)
		C2H2 Zn finger	476..505	CDD:275368	6/28 (21%)
		C2H2 Zn finger	513..533	CDD:275368	6/19 (32%)
		C2H2 Zn finger	545..565	CDD:275368	8/19 (42%)
		C2H2 Zn finger	568..584	CDD:275368	3/15 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45449782
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	91	1.000	Inparanoid score	I2264
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.980