DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8301 and Zfp82

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_808557.2	Gene:	Zfp82 / 330502	MGIID:	1890753	Length:	530	Species:	Mus musculus

Alignment Length:	595	Identity:	158/595 - (26%)
Similarity:	230/595 - (38%)	Gaps:	125/595 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 LDLHHPNCWPSEMAQIRLQFANWNLKISPNDGL--------PQKI------CSDCFTKFCSINAF 76
            |||...|.:...|.:.....|:....||..|.:        |.|:      |.|..||..:...|
Mouse    23 LDLEQRNLYKDVMMENYHNVASLGCFISKPDVISLLEQGKEPWKVVRQRKPCPDSETKDETNQVF 87

  Fly    77 -RLACQEAQLKLSHIYDKIDASSLEDDEI--GQEDLEPAEEHQETETTKPTTTVSAETQPNNTAS 138
             .....|..|....|.::|..|.|:...:  |.|. ...:|.||
Mouse    88 SENGIYEMNLSQWKIMERIGNSGLKSLLLKNGWES-RRKQERQE--------------------- 130

  Fly   139 DPIEIFVDAVDIDEAEEEEEEEEQQQQYDEE----------VEEPITDESAPPQLTISYACKFCL 193
            ||.|.::..|        ....|:...|::.          ||:|             |.|..|
Mouse   131 DPQEGYLSQV--------RHTSERVSSYEKRALTTRQRIHFVEKP-------------YECNEC- 173

  Fly   194 RPQENYQLQQLLLEHINASHDPEQPYNCPECEARFQDAASRTVHLKSSHVEKQHACGVCGKKYGD 258
              .:.::::|.|..| :..|..|:||.|.||...|:..|..|.|.:....||.:.|..||:.:..
Mouse   174 --GKAFRVRQQLTFH-HRIHTGEKPYECKECGMAFRQTAHLTRHQRLHSGEKLYECKECGQAFIY 235

  Fly   259 RHNLRHHVEKYHSETDFECALCEKRFYTRKSLNYHMKWHNPDRQFKCRHSGCERLFISQRHLMCH 323
            ...||.|.:.:..|..:.|..|.|.|..|..|..|.:.|..::.:.|:.  |.:.|....||..|
Mouse   236 GPELRAHQKLHTGEKPYTCRECGKAFRVRGQLTLHQRIHTGEKPYVCQE--CGKAFRQLAHLTRH 298

  Fly   324 EATHSGTSSRKSEHCGFCGKTFIHLKTLRWHIYRQHGGEKPYKCANCTEVFASYAEKRIHMLERH 388
            :..:  ...|..| |..|||.|:....||.| ::.|.|||||:|.:|.:.|            |.
Mouse   299 QKLN--VVDRLYE-CKECGKDFLCGSGLRVH-HKLHTGEKPYECKDCGKAF------------RV 347

  Fly   389 RENLTAIERS-------ECMLCRQPFSSEPDLIHHMSAEHLQRPGAPIIANNKRVLQQKRERQYS 446
            |:.||..:||       ||..|.:.||....||.|......::|
Mouse   348 RQQLTLHQRSHTGEKPYECTECGKTFSRGYHLILHHRIHTGEKP--------------------- 391

  Fly   447 GLFQCGSCSQRFNMKSALERHAAVHSEKDRPHACPHCSKRFKRAQDMKWHIKTHEKEKPNVCDVC 511
              ::|..|.:.|:..|.|..|.::|... :|:.|..|.|.|:....:..|...|..|||..|..|
Mouse   392 --YECKECWKAFSRYSQLISHQSIHIGV-KPYDCKDCGKAFRLLSQLTQHQSVHAGEKPYSCKEC 453

  Fly   512 GKAFALKYVLTQHRLSHEVLEKNFKCNVCGRAYLFEKSLRLHQRTHTGKTYYKCDLCQERFVTHI 576
            ||:|.|:..|..|:..| ..||.|:|..|.:|:....||..|.|.|:|:..|:|..|::.|..|.
Mouse   454 GKSFRLRQKLALHQSIH-TGEKPFECKECRKAFRLNSSLIQHLRIHSGEKPYECKECKKAFRQHS 517

  Fly   577 KLKTHMQKAH 586
            .| ||..|.|
Mouse   518 HL-THHLKVH 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071	18/75 (24%)
		COG5048	198..>508	CDD:227381	88/316 (28%)
		C2H2 Zn finger	221..241	CDD:275368	7/19 (37%)
		C2H2 Zn finger	249..269	CDD:275368	6/19 (32%)
		C2H2 Zn finger	277..297	CDD:275368	7/19 (37%)
		C2H2 Zn finger	305..327	CDD:275368	6/21 (29%)
		C2H2 Zn finger	338..359	CDD:275368	8/20 (40%)
		C2H2 Zn finger	367..384	CDD:275368	3/16 (19%)
		C2H2 Zn finger	400..420	CDD:275368	7/19 (37%)
		C2H2 Zn finger	451..471	CDD:275368	6/19 (32%)
		C2H2 Zn finger	480..500	CDD:275368	5/19 (26%)
		C2H2 Zn finger	508..528	CDD:275368	8/19 (42%)
		C2H2 Zn finger	537..557	CDD:275368	7/19 (37%)
		C2H2 Zn finger	565..582	CDD:275368	6/16 (38%)
Zfp82	NP_808557.2	KRAB	6..65	CDD:214630	9/41 (22%)
		KRAB	6..45	CDD:279668	6/21 (29%)
		COG5048	166..525	CDD:227381	121/419 (29%)
		C2H2 Zn finger	170..190	CDD:275368	5/23 (22%)
		zf-H2C2_2	183..207	CDD:290200	10/24 (42%)
		C2H2 Zn finger	198..218	CDD:275368	7/19 (37%)
		C2H2 Zn finger	226..246	CDD:275368	6/19 (32%)
		zf-H2C2_2	238..261	CDD:290200	7/22 (32%)
		C2H2 Zn finger	254..274	CDD:275368	7/19 (37%)
		zf-H2C2_2	267..291	CDD:290200	6/25 (24%)
		C2H2 Zn finger	282..301	CDD:275368	6/20 (30%)
		C2H2 Zn finger	310..330	CDD:275368	8/20 (40%)
		zf-H2C2_2	323..345	CDD:290200	11/22 (50%)
		C2H2 Zn finger	338..358	CDD:275368	8/31 (26%)
		zf-H2C2_2	351..375	CDD:290200	8/23 (35%)
		C2H2 Zn finger	366..386	CDD:275368	7/19 (37%)
		zf-H2C2_2	378..403	CDD:290200	7/47 (15%)
		C2H2 Zn finger	394..414	CDD:275368	6/19 (32%)
		C2H2 Zn finger	422..442	CDD:275368	5/19 (26%)
		C2H2 Zn finger	450..470	CDD:275368	8/19 (42%)
		C2H2 Zn finger	478..498	CDD:275368	7/19 (37%)
		zf-H2C2_2	490..515	CDD:290200	10/24 (42%)
		C2H2 Zn finger	506..526	CDD:275368	8/20 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100