DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8301 and AgaP_AGAP010500

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	XP_558034.2	Gene:	AgaP_AGAP010500 / 3291105	VectorBaseID:	AGAP010500	Length:	634	Species:	Anopheles gambiae

Alignment Length:	630	Identity:	144/630 - (22%)
Similarity:	224/630 - (35%)	Gaps:	185/630 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 DLHHPNCWPSEMAQIRLQFANWNLKISPND---GLPQKI-CSDCFTK-----FCSINAFRLACQ- 81
            |:.|.......:|:          .|||.|   .||:.. |:|..|:     |....| ...||
Mosquito   113 DIKHAQVQTEPVAE----------PISPQDIDSSLPKAAKCNDMGTQVELEHFLPSTA-ESGCQT 166

  Fly    82 EAQLKLSHIY--------DKIDASSLEDDEIGQEDLEPAEEHQETETTKPTTTVSAETQPNNTAS 138
            :.|:::.:|.        .|:|..:.....:|:||...::||:          :..|...:||.
Mosquito   167 DEQMEMENIIICSASSGSIKVDDGTTTPTVLGEEDESSSQEHE----------ILNENSIDNTL- 220

  Fly   139 DPIEIFVDAVDIDEAEEEEEEE-----EQQQQYDEEVEEPITD--ESAPPQLT-----------I 185
                       |...::|.|.|     ::..:.:...|..|.:  .|.|.|||           .
Mosquito   221 -----------IHFGDDENEYEMILLGDEPDEAENFTESKIINHRNSLPKQLTNDRQKRSSRSVK 274

  Fly   186 SYACKFCL---RP---QENYQLQQLLLEHINASHDPEQPYNCPECEARFQDAASRTVHLKSSHVE 244
            |..|.:|.   ||   .:::|:.:..||....|.|   .|.|.||   |.      |.:..:|.
Mosquito   275 SEHCGYCNLTGRPALLAQHFQVHKETLELCLESTD---YYRCSEC---FM------VFISQTHF- 326

  Fly   245 KQHACGVCGKKYGDRH------------NLRHHVEKYHSETDFECALCEKRFYTRKSLNYHMKWH 297
            ..|.|          |            :|:.|.|.|.:    ...||..|..|.|.:.
Mosquito   327 VDHVC----------HPVLPTEEVLYHSDLQTHEEFYRN----GIVLCMPRLKTIKKIG------ 371

  Fly   298 NPDRQFKCRHSGCERLFISQRHLM-CHEATHSGTSSR--------KSE-----H-CGFCGKTFIH 347
               .:::|  ..|.:...:....| .|..||.....:        ||.     | ||.|...|..
Mosquito   372 ---NRYQC--GRCMKYTTNSFETMRLHSLTHEAEDEKIDDIDVVWKSNLLNVMHVCGVCKGHFPD 431

  Fly   348 LKTLRWHIYRQHGGEKPYKCA-NCTEVFASYAEKRIHMLERHRENLTAIERSECMLCRQPFSSEP 411
            ...:|.|:|..   :..|.|. :|..:|.|:.....|...:|      :.::||.|      :.|
Mosquito   432 ATYIRQHLYFH---QDSYMCVYDCGMIFVSFLRMTRHFERKH------LMQAECEL------TVP 481

  Fly   412 DLIHHMSAEHLQRPGAPIIANNKRVLQQKRERQYSGLFQCGSCSQRFNMKSALERHAAVHSEKDR 476
            |...                      ||:.|..|    .|..|.:....:.:|::|...| .:.|
Mosquito   482 DAGQ----------------------QQEPEVDY----PCKLCGKLLTSEESLKKHLKYH-VRPR 519

  Fly   477 PHACPHCSKRFKRAQDMKWHIKTHEKEKPNVCDVCGKAFALKYVLTQHRLSHEVLEKNFKCNVCG 541
            .:.|..|.|.|.:..|:..|::.|..|:|..|.:|.|.|.....|..|..:||.:.| |:|:||.
Mosquito   520 KYVCMECKKSFSQRSDLNNHLRIHTDERPYACKLCDKKFRTNSHLRDHMFTHEEVNK-FECDVCH 583

  Fly   542 RAYLFEKSLRLHQRTHTGKTYYKCDLCQERFVTHIKLKTHMQKAH 586
            :.:..::.|..|.|.|.||..|:|..|.:.||....|..| ||.|
Mosquito   584 KMFKAKRILAEHARLHLGKKPYQCKQCSKSFVRKQHLIVH-QKTH 627

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071	17/69 (25%)
		COG5048	198..>508	CDD:227381	71/337 (21%)
		C2H2 Zn finger	221..241	CDD:275368	5/19 (26%)
		C2H2 Zn finger	249..269	CDD:275368	5/31 (16%)
		C2H2 Zn finger	277..297	CDD:275368	5/19 (26%)
		C2H2 Zn finger	305..327	CDD:275368	4/22 (18%)
		C2H2 Zn finger	338..359	CDD:275368	7/20 (35%)
		C2H2 Zn finger	367..384	CDD:275368	4/17 (24%)
		C2H2 Zn finger	400..420	CDD:275368	4/19 (21%)
		C2H2 Zn finger	451..471	CDD:275368	4/19 (21%)
		C2H2 Zn finger	480..500	CDD:275368	6/19 (32%)
		C2H2 Zn finger	508..528	CDD:275368	6/19 (32%)
		C2H2 Zn finger	537..557	CDD:275368	6/19 (32%)
		C2H2 Zn finger	565..582	CDD:275368	5/16 (31%)
AgaP_AGAP010500	XP_558034.2	zf-AD	15..93	CDD:285071
		COG5048	<493..627	CDD:227381	44/140 (31%)
		C2H2 Zn finger	495..515	CDD:275368	4/19 (21%)
		zf-C2H2	521..543	CDD:278523	6/21 (29%)
		C2H2 Zn finger	523..543	CDD:275368	6/19 (32%)
		zf-H2C2_2	535..560	CDD:290200	9/24 (38%)
		C2H2 Zn finger	551..599	CDD:275368	16/48 (33%)
		C2H2 Zn finger	579..596	CDD:275370	4/16 (25%)
		zf-H2C2_2	592..616	CDD:290200	10/23 (43%)
		zf-C2H2	605..627	CDD:278523	9/22 (41%)
		C2H2 Zn finger	607..627	CDD:275368	8/20 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR24377
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100