DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8301 and CG2202

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_572657.2	Gene:	CG2202 / 32014	FlyBaseID:	FBgn0030240	Length:	889	Species:	Drosophila melanogaster

Alignment Length:	623	Identity:	143/623 - (22%)
Similarity:	223/623 - (35%)	Gaps:	194/623 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 CRTCAISMFVCDFE--NGSNNSHFLDLHHPNCWPSEMAQIRLQFANWNLKISPNDGLPQKICSDC 66
            |.|..||....|.|  ||:|.:.:|.:....|..:|...:.:|     ||:.......:|..:..
  Fly   292 CNTNPISSNEDDGEEANGANQTLWLHIKPEPCLEAEEVDLAMQ-----LKLEKKRRRREKAEAQA 351

  Fly    67 FTKF-CSINAFRLACQEAQLKLSHIYDKIDASSLEDDEIGQEDLEP--AEEHQETETTKPTTTVS 128
            .|.. .::....:|..::|..:..          |:..:|.:|..|  .|:..:...: ....:|
  Fly   352 ETSIDRTVKNEHIAIGDSQFSIKE----------ENQLVGSDDEAPMGVEDFMKLHVS-GELPLS 405

  Fly   129 AETQPNNTASDPIEIFVDAVDIDEAEEEEEEEEQQQQYDEEV---EEPI---------------- 174
            .|.:.:..|.|      |: |:|:.:::::||:.....|.|.   :||:
  Fly   406 DEERFDGFADD------DS-DLDDDDDDDDEEDAGDDDDGEFRLKQEPLDGEKPLKKAKSGRRRR 463

  Fly   175 ---TDESAPPQLTISYACKFCLRPQENYQLQQLLLEHINASHDPEQPYNCPECEARFQDAASRTV 236
               .||..|..     .|:.|   |..:.....||.| ..||..::|:|||.|...|..:.....
  Fly   464 RRNKDEPNPDN-----RCEVC---QRTFSRHCHLLRH-KLSHLEKKPHNCPHCPKAFARSDHLKA 519

  Fly   237 HLKSSHVEKQHACGVCGKKYGDRHNL-RHHVEKYHSE------------TDFECALCEKRFYTRK 288
            |::|.|..|:|.|.:|...:.....| ||.|.|::.|            .:..|..|.|||.::.
  Fly   520 HVQSLHSNKEHKCSLCEAAFSRLDALERHKVSKHNGEGLEPGSELKLQLAEHTCEYCSKRFSSKT 584

  Fly   289 SLNYHMKWHNPDRQFKCRHSGCERLFISQRHLMCHEATHSGTSSRKSEHCGFCGKTFIHLKTLRW 353
            .|..|...|. |..:.|:  .|:..|..:..|..||.||:|   :::..|..||.:|.....||.
  Fly   585 YLRKHTLLHT-DFLYACK--TCDETFRERAQLREHEKTHTG---QRNFLCCICGDSFARNDYLRV 643

  Fly   354 HIYRQHGGEKPYKCANCTEVFASYAEKRIHMLERHRENLTAIERSECMLCRQPFSSEPDLIHHMS 418
            |: |:|.|||||||
  Fly   644 HM-RRHNGEKPYKC--------------------------------------------------- 656

  Fly   419 AEHLQRPGAPIIANNKRVLQQKRERQYSGLFQCGSCSQRFNMKSALERHAAVHSEKDRPHACPHC 483
                                                  ||                        |
  Fly   657 --------------------------------------RF------------------------C 659

  Fly   484 SKRFKRAQDMKWHIKTHEKEKPNVCDVCGKAFALKYVLTQHRLSHEVLEKNFKCNVCGRAYLFEK 548
            .|.|.||.|:|.|.:.|...|||:|:.|||:|...|.||.|..:| ..|:.:||:.|.:::....
  Fly   660 VKAFPRATDLKVHERYHTGTKPNLCNTCGKSFHRAYNLTIHMRTH-TGERPYKCDQCPKSFTQSN 723

  Fly   549 SLRLHQRTHTGKTYYKCDLCQERFVTHIKLKTHMQKAH 586
            .|:.|.|.|||:. |||..|...|:....::.|...||
  Fly   724 DLKAHIRRHTGER-YKCPHCDAYFLQLYNMRNHCMSAH 760

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071	19/85 (22%)
		COG5048	198..>508	CDD:227381	72/322 (22%)
		C2H2 Zn finger	221..241	CDD:275368	5/19 (26%)
		C2H2 Zn finger	249..269	CDD:275368	6/20 (30%)
		C2H2 Zn finger	277..297	CDD:275368	7/19 (37%)
		C2H2 Zn finger	305..327	CDD:275368	6/21 (29%)
		C2H2 Zn finger	338..359	CDD:275368	8/20 (40%)
		C2H2 Zn finger	367..384	CDD:275368	1/16 (6%)
		C2H2 Zn finger	400..420	CDD:275368	0/19 (0%)
		C2H2 Zn finger	451..471	CDD:275368	2/19 (11%)
		C2H2 Zn finger	480..500	CDD:275368	8/19 (42%)
		C2H2 Zn finger	508..528	CDD:275368	9/19 (47%)
		C2H2 Zn finger	537..557	CDD:275368	5/19 (26%)
		C2H2 Zn finger	565..582	CDD:275368	3/16 (19%)
CG2202	NP_572657.2	zf-AD	45..121	CDD:285071
		C2H2 Zn finger	150..171	CDD:275368
		C2H2 Zn finger	192..213	CDD:275370
		C2H2 Zn finger	221..239	CDD:275370
		COG5048	<443..730	CDD:227381	96/416 (23%)
		C2H2 Zn finger	476..496	CDD:275368	6/23 (26%)
		zf-H2C2_2	488..513	CDD:290200	11/25 (44%)
		C2H2 Zn finger	504..525	CDD:275368	6/20 (30%)
		C2H2 Zn finger	532..548	CDD:275368	3/15 (20%)
		C2H2 Zn finger	573..593	CDD:275368	7/19 (37%)
		C2H2 Zn finger	600..620	CDD:275368	6/21 (29%)
		zf-H2C2_2	613..637	CDD:290200	10/26 (38%)
		C2H2 Zn finger	628..648	CDD:275368	8/20 (40%)
		zf-H2C2_2	640..663	CDD:290200	16/136 (12%)
		C2H2 Zn finger	656..676	CDD:275368	11/132 (8%)
		C2H2 Zn finger	684..704	CDD:275368	9/19 (47%)
		zf-C2H2	684..704	CDD:278523	9/19 (47%)
		zf-H2C2_2	696..721	CDD:290200	8/25 (32%)
		C2H2 Zn finger	712..732	CDD:275368	5/19 (26%)
		C2H2 Zn finger	739..755	CDD:275368	3/15 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	91	1.000	Inparanoid score	I2264
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.050