DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8301 and Zfp182

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	XP_036017871.1	Gene:	Zfp182 / 319535	MGIID:	2442220	Length:	682	Species:	Mus musculus

Alignment Length:	593	Identity:	157/593 - (26%)
Similarity:	247/593 - (41%)	Gaps:	123/593 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 MAQIRLQFANWNLKISPNDGLPQKICSDCFTKFCSINAFRLAC-QEAQLKLSHIYDK-------- 93
            :.|:||          |||.:..| ....:|.|  .|||.|:. ....::.||.::.
Mouse   175 LMQVRL----------PNDNIITK-SGQNYTDF--RNAFHLSTGLLVPMQRSHKFESFGNTMVDN 226

  Fly    94 ---IDASSLEDDEIGQEDLEPAEEHQETETTKPTTTVSAETQPNNTASDPIEIFVDAVDIDEAEE 155
               :..||.|:    :.|...|:....||...|.                   |:    :.....
Mouse   227 LNLLTGSSTEN----KHDTGCAKFFFHTEYENPN-------------------FI----VKPCGY 264

  Fly   156 EEEEEEQQQQYDEEVEEPITDESAPPQLTISYACKFCLRPQENYQLQQLLLEHINASHDPEQPYN 220
            :|.|:..:|:....:.:.|.:...|      :.|..|   |:.:..:..|:.|.. :|..|:|:.
Mouse   265 KEYEKTLRQKKGLSLHQRIKNGERP------FECTAC---QKTFSKKSHLIVHWR-THTGEKPFE 319

  Fly   221 CPECEARFQDAASRTVHLKSSHVEKQHACGVCGKKYGDRHNLRHHVEKYHSETDFECALCEKRFY 285
            |.||...|...:...:||::...|:..||..|||.:.::..:..|...:..|..:||..|.|.|.
Mouse   320 CSECGKAFSQKSQLIIHLRTHTGERPFACPECGKAFREKSTVIIHYRTHTGEKPYECNQCGKAFT 384

  Fly   286 TRKSLNYHMKWHNPDRQFKCRHSGCERLFISQRHLMCHEATHSGTSSRKSEHCGFCGKTFIHLKT 350
            .:.:|..|.|.|..::.::|  :.|...||.:..|:.|.:||:|   :|...|..|.|||....|
Mouse   385 QKSNLIVHQKTHTGEKTYEC--TKCGESFIQKLDLIIHHSTHTG---KKPHECSECKKTFSDKST 444

  Fly   351 LRWHIYRQHGGEKPYKCANCTEVFASYAEK-------RIHMLER------------HRENLTAIE 396
            |..| .|.|.||||:||..|.:   |:.||       |||..|:            .:.||...:
Mouse   445 LVIH-QRTHTGEKPHKCTECGK---SFNEKSTLIVHQRIHTGEKPYECDVCGKTFTQKSNLGVHQ 505

  Fly   397 RS-------ECMLCRQPFSSEPDLIHHMSAEHLQRPGAPIIANNKRVLQQKRERQYSGLFQCGSC 454
            |:       ||..|.:.||.:..|:.|......::|                       ::|..|
Mouse   506 RTHSGEKPFECNECEKAFSQKSYLMLHQRGHTGEKP-----------------------YECNEC 547

  Fly   455 SQRFNMKSALERHAAVHSEKDRPHACPHCSKRFKRAQDMKWHIKTHEKEKPNVCDVCGKAFALKY 519
            .:.|:.||.|..|...|:| ::|:.|..|.|.|:....:..|.:.|..|||..|.||.|||:.|.
Mouse   548 EKAFSQKSYLIIHQRTHTE-EKPYKCNECGKAFREKSKLIIHQRIHTGEKPYECLVCWKAFSQKS 611

  Fly   520 VLTQHRLSHEVLEKNFKCNVCGRAYLFEKSLRLHQRTHTGKTYYKCDLCQERFVTHIKLKTHMQK 584
            .|..|:.:| ..||.::|..||:|:..:.:..:|||||||:..|||..|.:.|.....|..| |:
Mouse   612 QLIIHQRTH-TGEKPYECTECGKAFREKSTFTVHQRTHTGEKPYKCIECGKAFTQKSNLIVH-QR 674

  Fly   585 AHAASQPH 592
            .|...:.|
Mouse   675 THTVKKAH 682

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071	13/49 (27%)
		COG5048	198..>508	CDD:227381	92/335 (27%)
		C2H2 Zn finger	221..241	CDD:275368	6/19 (32%)
		C2H2 Zn finger	249..269	CDD:275368	5/19 (26%)
		C2H2 Zn finger	277..297	CDD:275368	7/19 (37%)
		C2H2 Zn finger	305..327	CDD:275368	6/21 (29%)
		C2H2 Zn finger	338..359	CDD:275368	9/20 (45%)
		C2H2 Zn finger	367..384	CDD:275368	7/23 (30%)
		C2H2 Zn finger	400..420	CDD:275368	6/19 (32%)
		C2H2 Zn finger	451..471	CDD:275368	7/19 (37%)
		C2H2 Zn finger	480..500	CDD:275368	5/19 (26%)
		C2H2 Zn finger	508..528	CDD:275368	9/19 (47%)
		C2H2 Zn finger	537..557	CDD:275368	7/19 (37%)
		C2H2 Zn finger	565..582	CDD:275368	4/16 (25%)
Zfp182	XP_036017871.1	KRAB	63..139	CDD:214630
		COG5048	288..677	CDD:227381	127/433 (29%)
		C2H2 Zn finger	292..312	CDD:275368	5/23 (22%)
		C2H2 Zn finger	320..340	CDD:275368	6/19 (32%)
		C2H2 Zn finger	348..368	CDD:275368	5/19 (26%)
		C2H2 Zn finger	376..396	CDD:275368	7/19 (37%)
		C2H2 Zn finger	404..424	CDD:275368	6/21 (29%)
		C2H2 Zn finger	432..452	CDD:275368	9/20 (45%)
		C2H2 Zn finger	460..480	CDD:275368	6/22 (27%)
		C2H2 Zn finger	488..508	CDD:275368	3/19 (16%)
		C2H2 Zn finger	516..536	CDD:275368	6/19 (32%)
		C2H2 Zn finger	544..564	CDD:275368	7/19 (37%)
		C2H2 Zn finger	572..592	CDD:275368	5/19 (26%)
		C2H2 Zn finger	600..620	CDD:275368	9/19 (47%)
		C2H2 Zn finger	628..648	CDD:275368	7/19 (37%)
		C2H2 Zn finger	656..676	CDD:275368	6/20 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100