DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8301 and Zfp563

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	XP_038934898.1	Gene:	Zfp563 / 314584	RGDID:	1308729	Length:	455	Species:	Rattus norvegicus

Alignment Length:	517	Identity:	133/517 - (25%)
Similarity:	201/517 - (38%)	Gaps:	125/517 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    99 LEDDE-----IGQEDLEPAEEHQETETTKPT-----TTVSAETQPNNTASDPIEIFVDAVDIDEA 153
            :.|||     :..||:......:|.:...|:     |.|..||..|..|...||....:.|.||.
  Rat     1 MRDDECEMDCLTFEDVAVNFTLEEWDLLDPSQKQLYTDVMQETFKNLIAIGQIEEGRRSKDDDEE 65

  Fly   154 EE------------EEEEEEQQQQYDEEVEEPITDESAP--PQLTISYACKFCL----------- 193
            ..            :..|..|.::...|..:.:.::..|  .:|..|:.|:..|
  Rat    66 SRRSLRSGLVELLCKPRESRQCEEIFSEFPDTVVNKKTPHGVKLCESHLCEDILIGLPPLNMHIP 130

  Fly   194 -----RP--QENYQ--------------LQQLLLEHINASHDPEQPYNCPECEARFQDAASRTVH 237
                 ||  .|.|:              ..:..|:|.|| |..|:||.|.:|...|..::....|
  Rat   131 VQRGHRPYEYETYEDSLYKFRECGKAFLYSECYLKHENA-HIIEKPYKCQQCGKAFSSSSKVRRH 194

  Fly   238 LKSSHVEKQHACGVCGKKYGDRHNLRHHVEKYHSETDFECALCEKRFYTRKSLNYHMKWHNPDRQ 302
            .::...||.:.|..|||.:..|.:||.|...:..|..|.|..|.|.|..:.||..|.:.|:.::.
  Rat   195 ERTHTGEKPYMCNHCGKAFPSRGSLRRHDRIHSGEKPFVCKYCGKAFTGQSSLPRHERIHSGEKP 259

  Fly   303 FKCRHSGCERLFISQRHLMCHEATHSGTSSRKSEHCGFCGKTFIHLKTLRWHIYRQHGGEKPYKC 367
            :.|::  |.:.|||......||.||:|   .|...|..|.|......:||.| .|.|.|||||.|
  Rat   260 YVCKY--CGKCFISSSTCRVHERTHTG---EKLYVCNLCNKAVTTRTSLRNH-ERIHSGEKPYVC 318

  Fly   368 ANCTEVFASYAEKRIHMLERHRENLTAIERSECMLCRQPFSSEPDLIHHMSAEHLQRPGAPIIAN 432
            ..|.:.|.|....|||
  Rat   319 EQCGKGFISSGTFRIH------------------------------------------------- 334

  Fly   433 NKRVLQQKRERQYSG--LFQCGSCSQRFNMKSALERHAAVHSEKDRPHACPHCSKRFKRAQDMKW 495
                     ||.::|  .::|..|.:.|.::|:|:||..:|: :::|:.|..|.|.|.....::.
  Rat   335 ---------ERIHTGEKPYRCKECGKAFTIQSSLQRHERIHT-REKPYDCKECGKAFSGYSSLRR 389

  Fly   496 HIKTHEKEKPNVCDVCGKAFALKYVLTQHRLSHEVLEKNFKCNVCGRAYLFEKSLRLHQRTH 557
            |.:.|..|:|..|..|||||.......:|...| ..||.:.|..||:|:....|||:|::||
  Rat   390 HERIHSGERPYACKQCGKAFPALGDCQRHEQIH-TGEKPYICKQCGKAFTRCGSLRIHEKTH 450

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071
		COG5048	198..>508	CDD:227381	84/325 (26%)
		C2H2 Zn finger	221..241	CDD:275368	4/19 (21%)
		C2H2 Zn finger	249..269	CDD:275368	8/19 (42%)
		C2H2 Zn finger	277..297	CDD:275368	7/19 (37%)
		C2H2 Zn finger	305..327	CDD:275368	7/21 (33%)
		C2H2 Zn finger	338..359	CDD:275368	7/20 (35%)
		C2H2 Zn finger	367..384	CDD:275368	6/16 (38%)
		C2H2 Zn finger	400..420	CDD:275368	0/19 (0%)
		C2H2 Zn finger	451..471	CDD:275368	7/19 (37%)
		C2H2 Zn finger	480..500	CDD:275368	5/19 (26%)
		C2H2 Zn finger	508..528	CDD:275368	7/19 (37%)
		C2H2 Zn finger	537..557	CDD:275368	8/19 (42%)
		C2H2 Zn finger	565..582	CDD:275368
Zfp563	XP_038934898.1	KRAB	10..51	CDD:396083	10/40 (25%)
		C2H2 Zn finger	151..170	CDD:275368	4/19 (21%)
		COG5048	<174..335	CDD:227381	57/224 (25%)
		C2H2 Zn finger	178..198	CDD:275368	4/19 (21%)
		C2H2 Zn finger	206..226	CDD:275368	8/19 (42%)
		C2H2 Zn finger	234..254	CDD:275368	7/19 (37%)
		C2H2 Zn finger	262..282	CDD:275368	7/21 (33%)
		C2H2 Zn finger	290..310	CDD:275368	7/20 (35%)
		C2H2 Zn finger	318..338	CDD:275368	9/77 (12%)
		zf-H2C2_2	331..354	CDD:404364	8/80 (10%)
		C2H2 Zn finger	346..366	CDD:275368	7/19 (37%)
		zf-H2C2_2	358..382	CDD:404364	8/24 (33%)
		C2H2 Zn finger	374..394	CDD:275368	5/19 (26%)
		zf-H2C2_2	386..409	CDD:404364	8/22 (36%)
		C2H2 Zn finger	402..422	CDD:275368	7/19 (37%)
		zf-H2C2_2	416..439	CDD:404364	8/23 (35%)
		C2H2 Zn finger	430..450	CDD:275368	8/19 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100