DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8301 and Zfp189

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_001101400.1	Gene:	Zfp189 / 313219	RGDID:	1306510	Length:	608	Species:	Rattus norvegicus

Alignment Length:	551	Identity:	144/551 - (26%)
Similarity:	223/551 - (40%)	Gaps:	93/551 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   107 EDLEPAEEHQETETTKP----TTTVSAETQPNNTASDPIE----------IFVDAVDIDEAEEEE 157
            ||.||..:.:..:..:|    .|.:.:|...:...|:..|          ||:..:..|...||:
  Rat    46 EDEEPTVKEEIEKDIEPQGIIVTRIKSELDQDPMGSETFELVGRLDKQRGIFLWEIPRDSLTEEQ 110

  Fly   158 E-------------EEEQ------------------QQQYDEEVEEPITDESAPPQLTIS----- 186
            :             .||:                  |.|.....|:|..........:.|
  Rat   111 KMFRGHTNVRKRPNSEEKCHKCEECGKRFVRKAHFIQHQRVHTGEKPFQCNECGKSFSRSSFVIE 175

  Fly   187 ----------YACKFCLRPQENYQLQQLLLEHINASHDPEQPYNCPECEARFQDAASRTVHLKSS 241
                      |.|.:|   .:.:.:...|:.| ...|..|:||.|.:|:..|....|...|.:..
  Rat   176 HQRIHTGERPYECNYC---GKTFSVSSTLIRH-QRIHTGERPYQCNQCKQSFSQRRSLVKHQRIH 236

  Fly   242 HVEKQHACGVCGKKYGDRHNLRHHVEKYHSETDFECALCEKRFYTRKSLNYHMKWHNPDRQFKCR 306
            ..||.|.|..|||.:..:.:|..|...:..|..:.|..|:|.|.....|..|.:.|..:|..||
  Rat   237 TGEKPHKCSDCGKAFSWKSHLIEHQRTHTGEKPYHCTKCKKSFSRNSLLVEHQRIHTGERPHKC- 300

  Fly   307 HSGCERLFISQRHLMCHEATHSGTSSRKSEHCGFCGKTFIHLKTLRWHIYRQHGGEKPYKCANCT 371
             ..|.:.|....:|:.|:..|:|   .|...|..|||:|.....|..| .|.|.||:||:|..|.
  Rat   301 -GECGKAFRLSTYLIQHQKIHTG---EKPFLCIECGKSFSRSSFLIEH-QRIHTGERPYQCQECG 360

  Fly   372 EVFASYAEKRIHMLERHRENLTAIERSECMLCRQPFSSEPDLIHHMSAEHLQRPGAP-------I 429
            :.|:....     |.||:...|..:..:|..|.:.||....||.|... |::...:|       .
  Rat   361 KSFSQLCN-----LTRHQRIHTGDKPHKCEECGKAFSRSSGLIQHQRI-HIREKTSPFKETKGSF 419

  Fly   430 IANNKRVLQQK---RERQYSGLFQCGSCSQRFNMKSALERHAAVHSEKDRPHACPHCSKRFKRAQ 491
            ..|...|:||:   :|:.|    :|..|.:.|::.:.|.:|..:|: .::|:.|..|.|.|.|:.
  Rat   420 DPNCGLVIQQEVYPKEKSY----KCDDCGKTFSVSAHLVQHQRIHT-GEKPYLCTVCGKSFSRSS 479

  Fly   492 DMKWHIKTHEKEKPNVCDVCGKAFALKYVLTQHRLSHEVLEKNFKCNVCGRAYLFEKSLRLHQRT 556
            .:..|.:.|..|:|.:|..|||:|:....|.:|:..| ...|..||..||:|:.....|..|||.
  Rat   480 FLIEHQRIHTGERPYLCRQCGKSFSQLCNLIRHQGVH-TGNKPHKCEECGKAFSRNSGLIQHQRI 543

  Fly   557 HTGKTYYKCDLCQERFVTHIKLKTHMQKAHA 587
            |||:..|:|:.|.:.|.....|..| ||.||
  Rat   544 HTGEKPYRCEKCDKSFSQQRSLVNH-QKIHA 573

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071
		COG5048	198..>508	CDD:227381	89/319 (28%)
		C2H2 Zn finger	221..241	CDD:275368	5/19 (26%)
		C2H2 Zn finger	249..269	CDD:275368	6/19 (32%)
		C2H2 Zn finger	277..297	CDD:275368	6/19 (32%)
		C2H2 Zn finger	305..327	CDD:275368	5/21 (24%)
		C2H2 Zn finger	338..359	CDD:275368	8/20 (40%)
		C2H2 Zn finger	367..384	CDD:275368	3/16 (19%)
		C2H2 Zn finger	400..420	CDD:275368	7/19 (37%)
		C2H2 Zn finger	451..471	CDD:275368	5/19 (26%)
		C2H2 Zn finger	480..500	CDD:275368	6/19 (32%)
		C2H2 Zn finger	508..528	CDD:275368	7/19 (37%)
		C2H2 Zn finger	537..557	CDD:275368	8/19 (42%)
		C2H2 Zn finger	565..582	CDD:275368	4/16 (25%)
Zfp189	NP_001101400.1	KRAB_A-box	<10..39	CDD:143639
		COG5048	116..506	CDD:227381	104/410 (25%)
		C2H2 Zn finger	132..152	CDD:275368	2/19 (11%)
		zf-H2C2_2	144..169	CDD:290200	4/24 (17%)
		C2H2 Zn finger	160..180	CDD:275368	1/19 (5%)
		zf-H2C2_2	175..196	CDD:290200	3/23 (13%)
		C2H2 Zn finger	188..208	CDD:275368	4/23 (17%)
		zf-H2C2_2	201..225	CDD:290200	9/24 (38%)
		C2H2 Zn finger	216..236	CDD:275368	5/19 (26%)
		zf-H2C2_2	228..252	CDD:290200	9/23 (39%)
		C2H2 Zn finger	244..264	CDD:275368	6/19 (32%)
		zf-H2C2_2	256..281	CDD:290200	7/24 (29%)
		C2H2 Zn finger	272..292	CDD:275368	6/19 (32%)
		zf-H2C2_2	285..307	CDD:290200	7/23 (30%)
		C2H2 Zn finger	300..320	CDD:275368	5/21 (24%)
		zf-H2C2_2	312..337	CDD:290200	10/27 (37%)
		C2H2 Zn finger	328..348	CDD:275368	8/20 (40%)
		zf-H2C2_2	341..365	CDD:290200	11/24 (46%)
		C2H2 Zn finger	356..376	CDD:275368	6/24 (25%)
		zf-H2C2_2	368..393	CDD:290200	7/29 (24%)
		C2H2 Zn finger	384..404	CDD:275368	7/20 (35%)
		C2H2 Zn finger	440..460	CDD:275368	5/19 (26%)
		zf-H2C2_2	452..477	CDD:290200	8/25 (32%)
		C2H2 Zn finger	468..488	CDD:275368	6/19 (32%)
		zf-H2C2_2	481..505	CDD:290200	9/23 (39%)
		C2H2 Zn finger	496..516	CDD:275368	7/19 (37%)
		zf-H2C2_2	508..533	CDD:290200	9/25 (36%)
		C2H2 Zn finger	524..544	CDD:275368	8/19 (42%)
		zf-H2C2_2	537..561	CDD:290200	11/23 (48%)
		C2H2 Zn finger	552..572	CDD:275368	7/20 (35%)
		C2H2 Zn finger	583..603	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100