DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8301 and Zfp354c

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_038950.3	Gene:	Zfp354c / 30944	MGIID:	1353621	Length:	560	Species:	Mus musculus

Alignment Length:	569	Identity:	148/569 - (26%)
Similarity:	228/569 - (40%)	Gaps:	105/569 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 LQFANWNLKISPN-DGLPQKICSDCFTKFCSINAFRLACQEAQLKLSHIYDKIDASSL---EDDE 103
            |.|..|     |. :.||.|  .|..||..|....:....:.      :|.||....|   |..:
Mouse    84 LDFEIW-----PEIEALPPK--QDVLTKETSHGLIKNGSTKC------VYWKISFGELVKTECRD 135

  Fly   104 IGQEDLEP-----AEEHQETETTKPTTTVSAETQPNNTASDPIEIFVDAVDIDEAEEEEEEEEQQ 163
            |.||..:.     ||..:||.:...|.|.....:|         :|:....:  ::|.:..|...
Mouse   136 IAQEQEKKVHGPGAESPKETTSEDGTPTGFEPEKP---------LFISKALV--SQEGDPTESVP 189

  Fly   164 QQYDEEVEEPITDESAPPQLTISYACKFCLRPQENYQLQQLLLEHINASHDPEQPYNCPECEARF 228
            ..|.       |.|...||       .|.|  ..::|:           :..::|:.|.||...|
Mouse   190 ATYH-------TSEKDLPQ-------DFDL--MRSFQM-----------YPGQKPHVCSECGKGF 227

  Fly   229 QDAASRTVHL---KSSHV-EKQHACGVCGKKYGDRHNLRHHVEKYHSETDFECALCEKRFYTRKS 289
                ::::||   |..|. ||.:.|..|||.:..|.:|..|...:..|..::|:.|||.|.:..:
Mouse   228 ----TQSLHLLEHKRLHTGEKPYKCSECGKSFSHRSSLLAHQRTHTGEKPYKCSECEKAFGSSST 288

  Fly   290 LNYHMKWHNPDRQFKCRHSGCERLFISQRHLMCHEATHSGTSSRKSEHCGFCGKTFIHLKTLRWH 354
            |..|::.|..::.::||.  |.:.|.....|..|:..|:|   .|...|..|.|.|.....|..|
Mouse   289 LIKHLRVHTGEKPYRCRQ--CGKAFSQCSTLTVHQRIHTG---EKLYKCAECDKAFNCRAKLHRH 348

  Fly   355 IYRQHGGEKPYKCANCTEVFASYAEKRIHMLERHRENLTAIERSECMLCRQPFSSEPDLIHHMSA 419
             .|.|.||||||||.|.:.::.:..     |..|:...|..:..:|:.|.:.|:....||.|...
Mouse   349 -QRIHTGEKPYKCAECGKGYSQFPS-----LAEHQRLHTGEQLCQCLQCGRTFTRVSTLIEHQRI 407

  Fly   420 EHLQRPGAPIIANNKRVLQQKRERQYSGLFQCGSCSQRFNMKSALERHAAVHSEKDRPHACPHCS 484
            ...|:|                       :||..|.:.||..|:...|..:|: .::.:.|..|.
Mouse   408 HTGQKP-----------------------YQCNECGKTFNQYSSFNEHRKIHT-GEKLYTCEECG 448

  Fly   485 KRFKRAQDMKWHIKTHEKEKPNVCDVCGKAFALKYVLTQHRLSHEVLEKNFKCNVCGRAYLFEKS 549
            |.|....::..|.:.|..|||..|:.|||||:....||:|...| ..||.:||..||:||.:..:
Mouse   449 KAFGCKSNLYRHQRIHTGEKPYQCNQCGKAFSQYSFLTEHERIH-TGEKLYKCMECGKAYSYRSN 512

  Fly   550 LRLHQRTHTGKTYYKCDLCQERFVTHIKLKTHMQKAHAASQPHSADQPL 598
            |..|::.|..:..||.......|:....| |..||.....:|.:.:..|
Mouse   513 LCRHKKVHLKERLYKWKEYGTPFIYGSSL-TPYQKFLKGDKPENFNSSL 560

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071	11/44 (25%)
		COG5048	198..>508	CDD:227381	82/313 (26%)
		C2H2 Zn finger	221..241	CDD:275368	7/22 (32%)
		C2H2 Zn finger	249..269	CDD:275368	7/19 (37%)
		C2H2 Zn finger	277..297	CDD:275368	7/19 (37%)
		C2H2 Zn finger	305..327	CDD:275368	6/21 (29%)
		C2H2 Zn finger	338..359	CDD:275368	7/20 (35%)
		C2H2 Zn finger	367..384	CDD:275368	3/16 (19%)
		C2H2 Zn finger	400..420	CDD:275368	6/19 (32%)
		C2H2 Zn finger	451..471	CDD:275368	6/19 (32%)
		C2H2 Zn finger	480..500	CDD:275368	5/19 (26%)
		C2H2 Zn finger	508..528	CDD:275368	9/19 (47%)
		C2H2 Zn finger	537..557	CDD:275368	7/19 (37%)
		C2H2 Zn finger	565..582	CDD:275368	3/16 (19%)
Zfp354c	NP_038950.3	KRAB	14..74	CDD:214630
		KRAB	14..53	CDD:279668
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	139..168		7/28 (25%)
		COG5048	204..>543	CDD:227381	108/392 (28%)
		C2H2 Zn finger	220..240	CDD:275368	7/23 (30%)
		zf-H2C2_2	232..257	CDD:290200	10/24 (42%)
		C2H2 Zn finger	248..268	CDD:275368	7/19 (37%)
		zf-H2C2_2	260..283	CDD:290200	7/22 (32%)
		C2H2 Zn finger	276..296	CDD:275368	7/19 (37%)
		zf-H2C2_2	289..313	CDD:290200	7/25 (28%)
		C2H2 Zn finger	304..324	CDD:275368	6/21 (29%)
		zf-H2C2_2	317..341	CDD:290200	9/26 (35%)
		C2H2 Zn finger	332..352	CDD:275368	7/20 (35%)
		zf-H2C2_2	347..369	CDD:290200	12/22 (55%)
		C2H2 Zn finger	360..380	CDD:275368	5/24 (21%)
		C2H2 Zn finger	388..408	CDD:275368	6/19 (32%)
		zf-H2C2_2	401..425	CDD:290200	9/46 (20%)
		C2H2 Zn finger	416..436	CDD:275368	6/19 (32%)
		zf-H2C2_2	428..451	CDD:290200	5/23 (22%)
		C2H2 Zn finger	444..464	CDD:275368	5/19 (26%)
		zf-H2C2_2	456..481	CDD:290200	11/24 (46%)
		C2H2 Zn finger	472..492	CDD:275368	9/19 (47%)
		zf-H2C2_2	485..509	CDD:290200	12/24 (50%)
		C2H2 Zn finger	500..520	CDD:275368	7/19 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100