DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8301 and Zfp84

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	XP_038967513.1	Gene:	Zfp84 / 308482	RGDID:	1309815	Length:	922	Species:	Rattus norvegicus

Alignment Length:	763	Identity:	172/763 - (22%)
Similarity:	282/763 - (36%)	Gaps:	234/763 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 NNSHFLDLHHPNCWPSEMAQI-------RLQFANWNLKISPNDGLPQKICSDCFTKFCSINAFRL 78
            |.|||:.|......||.::.:       |::.|.|                  :....|:|
  Rat    46 NYSHFVSLGLAISKPSVISLLEQGKEPWRVEQAGW------------------YPDLLSVN---- 88

  Fly    79 ACQEAQLKLSH-----------IYDKIDASSLEDDEIGQEDLEPAEEHQETETTKPTTTVSAETQ 132
              :...|.|.|           :.:::.:|.||:...|  |........||:...|...:.....
  Rat    89 --EAKNLSLKHGIFGKESLKWKVTERVGSSCLEESRFG--DDWKCRGLLETKLESPDEYLQGVAA 149

  Fly   133 PNNTAS----DPIEIFVDAVDIDEAEEEEEEEEQQQQYDEEVEEPITD----------------- 176
            |:..||    .|..|.:.  ::..:|.::.|:|..:...::|..|.:|
  Rat   150 PSEKASTEFIQPAPIALS--EMTHSERKQSEQEAGETITQQVRIPTSDKLNEMYENAFIYYTDEM 212

  Fly   177 -------------------------ESAPPQLTIS-YACKFC--LRPQENYQLQ----------- 202
                                     :.||.|:... |.|:.|  :..:..|.:|
  Rat   213 KRQQAFAGDRCDELKGCSRGFAYDFQLAPYQINKKPYQCEICGKIFEKHAYLVQHNRFHTGEKPC 277

  Fly   203 ------------QLLLEHINA---------------------------SHDPEQPYNCPECEARF 228
                        .||::|...                           :|..|:||.|.:|:..|
  Rat   278 ECKECGKAFTNCSLLVQHQRVHTDEKPYECKHCGKAFLYFSTFFQHQRTHTNEKPYECHKCQKAF 342

  Fly   229 QDAASRTVHLKSSHVEKQHACGVCGKKYGDRHNLRHHVEKYHSETDFECALCEKRFYTRKSLNYH 293
            ..:|:.|.|.:....||.:.|.:|||.:....||..|.:.:..|..:||..|||.|....:...|
  Rat   343 NKSANLTRHQRIHSGEKPYECNLCGKTFTWASNLNDHQKIHTGEKPYECNYCEKAFLCHSAFMKH 407

  Fly   294 MKWHNPDRQFKCRHSGCERLFISQRHLMCHEATHSGTSSRKSEHCG------------------- 339
            .:.|..::.::|:.  |.:.|..:.||:.|:..|:|....:.:.||
  Rat   408 YRTHTNEKPYECQE--CMKAFRQKAHLIQHQRVHTGEKPYECKECGKAFACPSYFNRHQRIHTGE 470

  Fly   340 ------FCGKTFIHLKTLRWHIYRQHGGEKPYKCANCTEVFASYAEKRIHMLERHRENLTAIERS 398
                  .|||.||..|||..| .|.|.||||::|..|::.|    .:|.| |.:|:...|..:..
  Rat   471 RPYECKECGKAFIDCKTLILH-QRIHTGEKPFQCQQCSKAF----RQRSH-LTQHQRIHTGEKPY 529

  Fly   399 ECMLCRQPFS-----SEPDLIHHMSAEHLQRP------GAPIIANNKRVLQQK--RERQYSG--L 448
            ||..|.|.|:     .:...:|..||.. ::|      |...     ||.||.  .:|.::|  .
  Rat   530 ECKECGQAFTRLLQVKKHQRVHTKSANG-EKPYECGECGKAF-----RVRQQLTFHQRIHTGEKP 588

  Fly   449 FQCGSCSQRFNMKSALERHAAVHSEKDRPHACPHCSKRFKRAQDMKWHIKTHEKEKPNVCDVCGK 513
            ::|..|.:.|...:.|.||..:|: .|:.:.|..|:|.|..:.|::.|.::|..|||..|..|||
  Rat   589 YECKECGKAFRQCAHLSRHQRIHA-SDKLYECKKCAKIFPCSLDLRGHQRSHVGEKPYDCKECGK 652

  Fly   514 AFALKYVLTQHRLSH--------EVLEKNFK-------------------CNVCGRAYLFEKSLR 551
            ||.::..|:.|:..|        ....|:|:                   |..||:|:|....||
  Rat   653 AFRVRGQLSLHQRIHTGEKPYGCTECGKSFRQVAHLTRHQRLNGGGSRHECKECGQAFLCSTGLR 717

  Fly   552 LHQRTHTGKTYYKCDLCQERFVTHIKLKTHMQKAHAASQPHSADQPLD 599
            ||.:.|||:..|.|..|.:.|....:|..|       .:.|:.::|.|
  Rat   718 LHHKLHTGEKPYDCKECGKAFRVRQQLTLH-------ERIHTGEKPFD 758

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071	13/72 (18%)
		COG5048	198..>508	CDD:227381	100/399 (25%)
		C2H2 Zn finger	221..241	CDD:275368	6/19 (32%)
		C2H2 Zn finger	249..269	CDD:275368	7/19 (37%)
		C2H2 Zn finger	277..297	CDD:275368	6/19 (32%)
		C2H2 Zn finger	305..327	CDD:275368	6/21 (29%)
		C2H2 Zn finger	338..359	CDD:275368	12/45 (27%)
		C2H2 Zn finger	367..384	CDD:275368	4/16 (25%)
		C2H2 Zn finger	400..420	CDD:275368	6/24 (25%)
		C2H2 Zn finger	451..471	CDD:275368	6/19 (32%)
		C2H2 Zn finger	480..500	CDD:275368	6/19 (32%)
		C2H2 Zn finger	508..528	CDD:275368	8/19 (42%)
		C2H2 Zn finger	537..557	CDD:275368	9/19 (47%)
		C2H2 Zn finger	565..582	CDD:275368	4/16 (25%)
Zfp84	XP_038967513.1	KRAB	14..73	CDD:214630	7/26 (27%)
		COG5048	243..607	CDD:227381	90/377 (24%)
		C2H2 Zn finger	251..271	CDD:275368	4/19 (21%)
		C2H2 Zn finger	279..299	CDD:275368	3/19 (16%)
		C2H2 Zn finger	307..327	CDD:275368	0/19 (0%)
		C2H2 Zn finger	335..355	CDD:275368	6/19 (32%)
		C2H2 Zn finger	363..383	CDD:275368	7/19 (37%)
		C2H2 Zn finger	391..411	CDD:275368	6/19 (32%)
		C2H2 Zn finger	419..439	CDD:275368	6/21 (29%)
		C2H2 Zn finger	447..467	CDD:275368	2/19 (11%)
		C2H2 Zn finger	475..495	CDD:275368	10/20 (50%)
		COG5048	499..912	CDD:227381	76/279 (27%)
		C2H2 Zn finger	503..523	CDD:275368	7/24 (29%)
		C2H2 Zn finger	531..551	CDD:275368	4/19 (21%)
		C2H2 Zn finger	563..583	CDD:275368	6/24 (25%)
		C2H2 Zn finger	591..611	CDD:275368	6/19 (32%)
		C2H2 Zn finger	619..639	CDD:275368	6/19 (32%)
		C2H2 Zn finger	647..667	CDD:275368	8/19 (42%)
		C2H2 Zn finger	675..694	CDD:275368	2/18 (11%)
		C2H2 Zn finger	703..723	CDD:275368	9/19 (47%)
		C2H2 Zn finger	731..751	CDD:275368	5/26 (19%)
		C2H2 Zn finger	759..779	CDD:275368	172/763 (23%)
		C2H2 Zn finger	787..807	CDD:275368
		C2H2 Zn finger	815..835	CDD:275368
		C2H2 Zn finger	843..863	CDD:275368
		C2H2 Zn finger	871..891	CDD:275368
		C2H2 Zn finger	899..919	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100