DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8301 and Zim1

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_001100943.1	Gene:	Zim1 / 308322	RGDID:	1310930	Length:	578	Species:	Rattus norvegicus

Alignment Length:	482	Identity:	123/482 - (25%)
Similarity:	192/482 - (39%)	Gaps:	95/482 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    96 ASSLEDDEIGQEDLEPAEEHQETETTKPTTTVSAETQPNNTASDPIEIFVDAVDIDEAEEEEEEE 160
            :.:|..::..:.|..|::..:::::|. ||.....|.|.|                    :|.|.
  Rat   170 SQNLRAEKTSKSDDRPSQNKEKSDSTS-TTEAGKTTNPGN--------------------QENES 213

  Fly   161 EQQQQYDEEVEEPITDESAPPQLTISYACKFCLRPQENYQLQQLLLEHINASHDPEQP------- 218
            ........:.......:|.||:.:.|........|            :.::|.:|::.
  Rat   214 AAPGTSSSQTPSTTAPQSTPPEKSTSGKDGQGKSP------------NTSSSTNPKRKPARQGKN 266

  Fly   219 -YNCPECEARFQDAASRTVHL---KSSHV-EKQHACGVCGKKYGDRHNLRHHVEKYHSET---DF 275
             :.|.||...|    ::|:||   :..|. ||.|.|..|||.:  || |.:.:..|...|   .:
  Rat   267 HFKCKECGKTF----NQTLHLVEHERIHTGEKPHKCDTCGKSF--RH-LSYFLTHYRIHTGVRPY 324

  Fly   276 ECALCEKRFYTRKSLNYHMKWHNPDRQFKCRHSGCERLFISQRHLMCHEATHSGTSSRKSEHCGF 340
            :|..|.|.|.:..:||.|.:.|:.::.|||  ..|.:.|.....|..|:..|:|   .|...||.
  Rat   325 KCKECGKAFNSSSTLNNHCRIHSGEKPFKC--DECGKTFKQSTKLTRHQRIHTG---EKPYKCGE 384

  Fly   341 CGKTFIHLKTLRWHIYRQHGGEKPYKCANCTEVFASYAEKRI--HMLERHRENLTAIERSECMLC 403
            |.|.|....:||.| .|.|.|||||:|..|.:.|      |:  |:.|..|.:| .::..:|..|
  Rat   385 CNKCFGRSSSLREH-KRIHTGEKPYRCQVCGKTF------RVNSHLSEHQRLHL-KVKPYKCDKC 441

  Fly   404 RQPFSSEPDLIHHMSAEHLQRPGAPIIANNKRVLQQKRERQYSGLFQCGSCSQRFNMKSALERHA 468
            .:.|.:...|..|   :.:..|||.:                    .|..|.:.|..|.||.:|.
  Rat   442 GKHFRNSSYLSEH---KQIHVPGARV--------------------DCPECGKVFACKVALLKHQ 483

  Fly   469 AVHSEKDRPHACPHCSKRFKRAQDMKWHIKTHEKEKPNVCDVCGKAFALKYVLTQHRLSHEVLEK 533
            ..|....| :.|..|.|.|:....::.|.:.|..|||.||..|.|.|..|..|..|...|.. ::
  Rat   484 KRHEANSR-YRCKGCGKTFRCKSSIQRHERLHAGEKPFVCTKCDKGFTDKTTLNNHLKIHSG-DR 546

  Fly   534 NFKCNVCGRAYLFEKSLRLHQRTHTGK 560
            ...|..|||.:....:|.:||:.|..|
  Rat   547 PDPCAQCGRTFKKLATLLIHQKKHNKK 573

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071
		COG5048	198..>508	CDD:227381	89/326 (27%)
		C2H2 Zn finger	221..241	CDD:275368	7/22 (32%)
		C2H2 Zn finger	249..269	CDD:275368	7/19 (37%)
		C2H2 Zn finger	277..297	CDD:275368	7/19 (37%)
		C2H2 Zn finger	305..327	CDD:275368	5/21 (24%)
		C2H2 Zn finger	338..359	CDD:275368	9/20 (45%)
		C2H2 Zn finger	367..384	CDD:275368	4/18 (22%)
		C2H2 Zn finger	400..420	CDD:275368	5/19 (26%)
		C2H2 Zn finger	451..471	CDD:275368	7/19 (37%)
		C2H2 Zn finger	480..500	CDD:275368	5/19 (26%)
		C2H2 Zn finger	508..528	CDD:275368	7/19 (37%)
		C2H2 Zn finger	537..557	CDD:275368	7/19 (37%)
		C2H2 Zn finger	565..582	CDD:275368
Zim1	NP_001100943.1	KRAB	51..106	CDD:214630
		KRAB	51..90	CDD:279668
		COG5048	<178..426	CDD:227381	75/299 (25%)
		C2H2 Zn finger	270..290	CDD:275368	7/23 (30%)
		zf-H2C2_2	282..307	CDD:290200	10/26 (38%)
		C2H2 Zn finger	298..318	CDD:275368	8/22 (36%)
		zf-H2C2_2	310..335	CDD:290200	6/24 (25%)
		C2H2 Zn finger	326..346	CDD:275368	7/19 (37%)
		zf-H2C2_2	339..363	CDD:290200	9/25 (36%)
		C2H2 Zn finger	354..374	CDD:275368	5/21 (24%)
		zf-H2C2_2	367..391	CDD:290200	10/26 (38%)
		C2H2 Zn finger	382..402	CDD:275368	9/20 (45%)
		zf-H2C2_2	394..417	CDD:290200	12/23 (52%)
		C2H2 Zn finger	410..430	CDD:275368	7/25 (28%)
		zf-H2C2_2	422..447	CDD:290200	7/25 (28%)
		C2H2 Zn finger	438..458	CDD:275368	5/22 (23%)
		C2H2 Zn finger	466..486	CDD:275368	7/19 (37%)
		C2H2 Zn finger	494..514	CDD:275368	5/19 (26%)
		C2H2 Zn finger	522..542	CDD:275368	7/19 (37%)
		C2H2 Zn finger	550..570	CDD:275368	7/19 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100