DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8301 and ZNF354C

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_055409.1	Gene:	ZNF354C / 30832	HGNCID:	16736	Length:	554	Species:	Homo sapiens

Alignment Length:	458	Identity:	128/458 - (27%)
Similarity:	198/458 - (43%)	Gaps:	67/458 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   144 FVDAVDIDEAEEEEEEEEQQQQYDEEVEEPITDESAPPQLTI--SYACKFCLRPQENYQLQQLLL 206
            |.:||:.:...|||:|::..:|..:..|:.|:::.....|.:  |......|..|::..::::..
Human   124 FEEAVEFESEIEEEQEKKPLRQMIDSHEKTISEDGNHTSLELGKSLFTNTALVTQQSVPIERIPN 188

  Fly   207 EHINASHDPEQPYNCPECEARFQDAASRTVHLKSSHVEKQHACGVCGKKYGDRHNLRHHVEKYHS 271
            .:.....|.:|.::..:|...:...             |.|.|..|||.:....:|..|...:..
Human   189 MYYTFGKDFKQNFDLMKCFQIYPGG-------------KPHICNECGKSFKQNLHLIEHQRIHTG 240

  Fly   272 ETDFECALCEKRFYTRKSLNYHMKWHNPDRQFKCRHSGCERLFISQRHLMCHEATHSGTSSRKSE 336
            |..::|..|||.|..|.||..|.:.|..::.:||..  ||:.|.:...|:.|...|:|   .|..
Human   241 EKPYKCNECEKTFSHRSSLLSHQRIHTGEKPYKCNE--CEKAFSNSSTLIKHLRVHTG---EKPY 300

  Fly   337 HCGFCGKTFIHLKTLRWHIYRQHGGEKPYKCANCTEVFASYAEKRIHMLERHRENLTAIERSECM 401
            .|..|||.|....||..| .|.|.|||.|||..|.:.|...|:     |.||:...|..:..:|.
Human   301 RCRECGKAFSQCSTLTVH-QRIHTGEKLYKCGECEKAFNCRAK-----LHRHQRIHTGEKPYKCS 359

  Fly   402 LCRQPFSSEPDLIHHMSAEHLQRPGAPIIANNKRVLQQKRERQYSG--LFQCGSCSQRFNMKSAL 464
            .|.:.:|....|     |||                    :|.::|  |:.|..|.:.|.....|
Human   360 ECGKGYSQFTSL-----AEH--------------------QRFHTGEQLYTCLECGRTFTRIVTL 399

  Fly   465 ERHAAVHSEKDRPHACPHCSKRFKRAQDMKWHIKTHEKEKPNVCDVCGKAFALKYVLTQHRLSHE 529
            ..|..:|:.: :|:.|..|.|.|.:......|.|.|..||...|:.|||||..|..|.:|:..|
Human   400 IEHQRIHTGQ-KPYQCNECEKAFNQYSSFNEHRKIHTGEKLYTCEECGKAFGCKSNLYRHQRIH- 462

  Fly   530 VLEKNFKCNVCGRAYLFEKSLRLHQRTHTGKTYYKC-----------DLCQERFVTHIKLKTHMQ 583
            ..||.::||.||:|:.....|..|:|.|||:..|||           :||:.:.| |.|.|.:..
Human   463 TGEKPYQCNQCGKAFSQYSFLTEHERIHTGEKLYKCMECGKAYSYRSNLCRHKKV-HTKEKLYKW 526

  Fly   584 KAH 586
            |.:
Human   527 KEY 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071
		COG5048	198..>508	CDD:227381	81/311 (26%)
		C2H2 Zn finger	221..241	CDD:275368	1/19 (5%)
		C2H2 Zn finger	249..269	CDD:275368	6/19 (32%)
		C2H2 Zn finger	277..297	CDD:275368	9/19 (47%)
		C2H2 Zn finger	305..327	CDD:275368	6/21 (29%)
		C2H2 Zn finger	338..359	CDD:275368	9/20 (45%)
		C2H2 Zn finger	367..384	CDD:275368	4/16 (25%)
		C2H2 Zn finger	400..420	CDD:275368	4/19 (21%)
		C2H2 Zn finger	451..471	CDD:275368	5/19 (26%)
		C2H2 Zn finger	480..500	CDD:275368	6/19 (32%)
		C2H2 Zn finger	508..528	CDD:275368	9/19 (47%)
		C2H2 Zn finger	537..557	CDD:275368	8/19 (42%)
		C2H2 Zn finger	565..582	CDD:275368	7/27 (26%)
ZNF354C	NP_055409.1	KRAB	12..72	CDD:214630
		KRAB	12..51	CDD:279668
		C2H2 Zn finger	194..210	CDD:275368	3/15 (20%)
		C2H2 Zn finger	218..238	CDD:275368	6/19 (32%)
		zf-H2C2_2	230..255	CDD:290200	8/24 (33%)
		COG5048	242..>541	CDD:227381	102/327 (31%)
		C2H2 Zn finger	246..266	CDD:275368	9/19 (47%)
		zf-H2C2_2	258..283	CDD:290200	9/26 (35%)
		C2H2 Zn finger	274..294	CDD:275368	6/21 (29%)
		zf-H2C2_2	287..311	CDD:290200	10/26 (38%)
		C2H2 Zn finger	302..322	CDD:275368	9/20 (45%)
		zf-H2C2_2	315..339	CDD:290200	12/24 (50%)
		C2H2 Zn finger	330..350	CDD:275368	7/24 (29%)
		zf-H2C2_2	345..367	CDD:290200	5/21 (24%)
		C2H2 Zn finger	358..378	CDD:275368	8/44 (18%)
		C2H2 Zn finger	386..406	CDD:275368	5/19 (26%)
		zf-H2C2_2	399..423	CDD:290200	8/24 (33%)
		C2H2 Zn finger	414..434	CDD:275368	6/19 (32%)
		C2H2 Zn finger	442..462	CDD:275368	9/19 (47%)
		zf-H2C2_2	454..479	CDD:290200	10/25 (40%)
		C2H2 Zn finger	470..490	CDD:275368	8/19 (42%)
		zf-H2C2_2	483..507	CDD:290200	9/23 (39%)
		C2H2 Zn finger	498..518	CDD:275368	4/20 (20%)
		C2H2 Zn finger	526..544	CDD:275368	1/4 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100