DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8301 and Zfp54

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_001100937.1	Gene:	Zfp54 / 308232	RGDID:	1307738	Length:	586	Species:	Rattus norvegicus

Alignment Length:	611	Identity:	150/611 - (24%)
Similarity:	240/611 - (39%)	Gaps:	127/611 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 WNLKISPNDGLPQKICSDCFTKFCSINAF-------------RLACQEAQL-KLSH------IYD 92
            |....||...|...:..:.::...|:..:             |.:||..:| |:.|      :|.
  Rat    27 WECLASPQRALYIDVMLENYSNLVSVENYCICDTVCQPVKTERESCQCNELGKMLHDPSHGGLYK 91

  Fly    93 KIDASS-------LEDDEIGQEDLEPAEEHQETET-TKPTTTVSAETQPNNTASDPIEIFVDAVD 149
            :.|.:.       .:|.::..:...| ::|:.|.| .:|.|:...|...:..::         :.
  Rat    92 RSDTTETSNNYRCCKDRDVSVDSSNP-DQHKSTHTGEEPCTSEDCEKSFDLCSN---------IT 146

  Fly   150 IDEAEEEEEEEEQQQQYDE-----------------------------------EVEEPITDESA 179
            .|:....||:|.:|:::|:                                   .:::.|...:.
  Rat   147 QDQTFYTEEKEHRQEKHDDHFSSTYSLMQQSIYIGANAGQCVKYGKCFSIASSLSIQQRIDTGNK 211

  Fly   180 PPQLTISYACKFCLRPQENYQLQQLLLEHINASHD----PEQPYNCPECEARFQDAASRTVHLKS 240
            |      |.|..|   .:::.....|..| ..:|.    ..:||.|.:||..|...::...|.|.
  Rat   212 P------YKCNIC---DKSFTQCSSLKTH-RKTHQRLRAGTKPYKCSDCEKSFSYLSALKSHQKR 266

  Fly   241 SHVEKQHACGVCGKKYGDRHNLRHHVEKYHSETDFECALCEKRFYTRKSLNYHMKWHNPDRQFKC 305
            ...||::.|..|.|.|..|..|:.|.:.:.::..:.|..|.|.|:.......|...|:.::.:||
  Rat   267 HTGEKRYKCKECDKSYAYRTGLKRHQKIHTAKERYSCQHCGKVFHQLSHFKSHFTVHSAEKPYKC 331

  Fly   306 RHSGCERLFISQRHLMCHEATHSGTSSRKSEHCGFCGKTFIHLKTLRWHIYRQHGGEKPYKCANC 370
            ..  |.|.|........|:..|   |.:||..|..|||:|..|..|:.| ||.|.|||||||..|
  Rat   332 NE--CHRSFPHYVFFRRHKKNH---SLQKSHKCKECGKSFFILSHLKTH-YRIHTGEKPYKCTEC 390

  Fly   371 TEVFASYAEKRIHMLERHRENLTAIERSECMLCRQPFSSEPDLIHHMSAEHLQRPGAPIIANNKR 435
            .:.|..|:.     |.||:...|..:...|.:|.:.|:....|..|
  Rat   391 DKSFTQYSH-----LRRHQRIYTGKKLYRCEVCDKWFTMSSSLSRH------------------- 431

  Fly   436 VLQQKRERQYSGLFQCGSCSQRFNMKSALERHAAVHS-EKDRPHACPHCSKRFKRAQDMKWHIKT 499
               ||...: :..::|..|...|...|:|.||..||: ||   |.|..|.|.|.|...::.|.:.
  Rat   432 ---QKIHTE-AKTYKCKDCDIFFTHYSSLRRHQRVHTGEK---HTCKQCGKSFTRGSTLRAHQRI 489

  Fly   500 HEKEKPNVCDVCGKAFALKYVLTQHRLSHEVLEKNFKCNVCGRAYLFEKSLRLHQRTHTGKTYYK 564
            |..|||..|..|.|:|.....|..|:..| ..|:.:.|..||::......||.||:.|||:..||
  Rat   490 HTGEKPYKCSKCDKSFIQASQLRTHQRVH-TGERPYVCKECGKSLTTCAILRAHQKIHTGEKPYK 553

  Fly   565 CDLCQERFVTHIKLKTHMQKAHAASQ 590
            |..|.:.::.:..||.| ||.|...:
  Rat   554 CMECGKSYIQYSHLKRH-QKVHTGEK 578

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071	9/52 (17%)
		COG5048	198..>508	CDD:227381	90/314 (29%)
		C2H2 Zn finger	221..241	CDD:275368	6/19 (32%)
		C2H2 Zn finger	249..269	CDD:275368	7/19 (37%)
		C2H2 Zn finger	277..297	CDD:275368	5/19 (26%)
		C2H2 Zn finger	305..327	CDD:275368	5/21 (24%)
		C2H2 Zn finger	338..359	CDD:275368	10/20 (50%)
		C2H2 Zn finger	367..384	CDD:275368	4/16 (25%)
		C2H2 Zn finger	400..420	CDD:275368	5/19 (26%)
		C2H2 Zn finger	451..471	CDD:275368	7/19 (37%)
		C2H2 Zn finger	480..500	CDD:275368	6/19 (32%)
		C2H2 Zn finger	508..528	CDD:275368	6/19 (32%)
		C2H2 Zn finger	537..557	CDD:275368	7/19 (37%)
		C2H2 Zn finger	565..582	CDD:275368	4/16 (25%)
Zfp54	NP_001100937.1	KRAB	12..52	CDD:396083	4/24 (17%)
		C2H2 Zn finger	191..207	CDD:275368	0/15 (0%)
		COG5048	210..546	CDD:227381	109/383 (28%)
		C2H2 Zn finger	215..235	CDD:275368	4/23 (17%)
		C2H2 Zn finger	247..267	CDD:275368	6/19 (32%)
		C2H2 Zn finger	275..295	CDD:275368	7/19 (37%)
		C2H2 Zn finger	303..323	CDD:275368	5/19 (26%)
		C2H2 Zn finger	331..351	CDD:275368	5/21 (24%)
		C2H2 Zn finger	359..379	CDD:275368	10/20 (50%)
		C2H2 Zn finger	387..407	CDD:275368	7/24 (29%)
		C2H2 Zn finger	415..435	CDD:275368	7/41 (17%)
		C2H2 Zn finger	443..463	CDD:275368	7/19 (37%)
		C2H2 Zn finger	470..490	CDD:275368	6/19 (32%)
		C2H2 Zn finger	498..518	CDD:275368	6/19 (32%)
		C2H2 Zn finger	526..546	CDD:275368	7/19 (37%)
		C2H2 Zn finger	554..574	CDD:275368	7/20 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100