DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8301 and Zfp612

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_001100898.2	Gene:	Zfp612 / 307839	RGDID:	1307197	Length:	675	Species:	Rattus norvegicus

Alignment Length:	500	Identity:	138/500 - (27%)
Similarity:	220/500 - (44%)	Gaps:	79/500 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   104 IGQEDLEPAEEHQETETT-KPTTTVSAETQPNNTASDPIEIFVDAVDIDEAEEEEEEEEQQQQYD 167
            :||:        |||::. ....:|||..  ....:.|:|..:.: .:....::......:|..|
  Rat   131 VGQQ--------QETQSAGSERESVSASN--GRAKTSPVEGHLPS-PMPHLSQDHASSAGEQYSD 184

  Fly   168 EEV--EEPITDESAPPQLTISYACKFCLRPQENYQLQQ--LLLEHINASHDPEQPYNCPECEARF 228
            .::  .|.||.:..|            |:.:|..:..|  ..:..:..|.|.|:||.|.||...|
  Rat   185 TKLTKNEKITAQETP------------LKHKELAEASQGSSQVNQLPESCDVEKPYQCTECGKAF 237

  Fly   229 QDAASRTVHLKSSHVEKQHACGVCGKKYG-DRHNLRHHVEKYHS-ETDFECALCEKRFYTRKSLN 291
            ...|....|.:..:.||...|..|||.:. ..|.:.|  :..|| |..::|.:|.|.|....||.
  Rat   238 SVKAKFVWHQRLHNGEKPFKCVECGKCFSYSSHYITH--QTIHSGEKPYQCKVCGKAFSVNGSLV 300

  Fly   292 YHMKWHNPDRQFKCRHS----GCERLFISQRHLMCHEATHSGTSSRKSEHCGFCGKTF-IHLKTL 351
            .|.:.|..::.::|:..    ||...:|:      |:.||:|   .|...|..|||.| ::.|.:
  Rat   301 RHQRIHTGEKPYQCKECGTGFGCSSAYIT------HQRTHTG---EKPYECSDCGKAFNVNAKLI 356

  Fly   352 RWHIYRQHGGEKPYKCANCTEVFASYAEKRIHMLERHRENLTAIERSECMLCRQPFSSEPDLIHH 416
            :..  |.|.|||||:|..|.:.|....:     |.:|:...|..:...|..|.:.|:....||.|
  Rat   357 QHQ--RIHTGEKPYECDVCGKGFRCSTQ-----LRQHQSIHTGEKPHRCSECGKGFTKNAKLIQH 414

  Fly   417 MSAEHLQRPGAPIIANNKRVLQQKRERQYSGLFQCGSCSQRFNMKSALERHAAVHSEKDRPHACP 481
            ......::|                       :.|..|.:.|:.|..|.:|..:|: .:||:.|.
  Rat   415 QRVHTGEKP-----------------------YACSDCGKTFSAKGKLIQHQRIHT-GERPYECS 455

  Fly   482 HCSKRFKRAQDMKWHIKTHEKEKPNVCDVCGKAFALKYVLTQHRLSHEVLEKNFKCNVCGRAYLF 546
            .|.|.|:....::.|::.|..|||..|:.|||||.:...|.|||.:| ..||.|:||.||:.:..
  Rat   456 ECGKSFRCNSQLRQHLRIHTGEKPYKCNECGKAFNVNAKLMQHRRTH-TGEKPFECNECGKCFTS 519

  Fly   547 EKSLRLHQRTHTGKTYYKCDLCQERFVTHIKLKTHMQKAHAASQP 591
            :::|..|||||||:..|:|..|.:.|..:.||..| |:.|...:|
  Rat   520 KRNLLDHQRTHTGEKPYQCKECGKAFSINAKLTRH-QQIHTREKP 563

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071
		COG5048	198..>508	CDD:227381	84/318 (26%)
		C2H2 Zn finger	221..241	CDD:275368	6/19 (32%)
		C2H2 Zn finger	249..269	CDD:275368	6/20 (30%)
		C2H2 Zn finger	277..297	CDD:275368	7/19 (37%)
		C2H2 Zn finger	305..327	CDD:275368	5/25 (20%)
		C2H2 Zn finger	338..359	CDD:275368	7/21 (33%)
		C2H2 Zn finger	367..384	CDD:275368	3/16 (19%)
		C2H2 Zn finger	400..420	CDD:275368	6/19 (32%)
		C2H2 Zn finger	451..471	CDD:275368	6/19 (32%)
		C2H2 Zn finger	480..500	CDD:275368	5/19 (26%)
		C2H2 Zn finger	508..528	CDD:275368	10/19 (53%)
		C2H2 Zn finger	537..557	CDD:275368	8/19 (42%)
		C2H2 Zn finger	565..582	CDD:275368	5/16 (31%)
Zfp612	NP_001100898.2	KRAB	14..74	CDD:214630
		C2H2 Zn finger	230..250	CDD:275368	6/19 (32%)
		COG5048	254..660	CDD:227381	106/353 (30%)
		C2H2 Zn finger	258..278	CDD:275368	6/21 (29%)
		C2H2 Zn finger	286..306	CDD:275368	7/19 (37%)
		C2H2 Zn finger	314..334	CDD:275368	5/25 (20%)
		C2H2 Zn finger	342..362	CDD:275368	7/21 (33%)
		C2H2 Zn finger	370..390	CDD:275368	5/24 (21%)
		C2H2 Zn finger	398..418	CDD:275368	6/19 (32%)
		C2H2 Zn finger	426..446	CDD:275368	6/19 (32%)
		C2H2 Zn finger	454..474	CDD:275368	5/19 (26%)
		C2H2 Zn finger	482..502	CDD:275368	10/19 (53%)
		C2H2 Zn finger	510..530	CDD:275368	8/19 (42%)
		C2H2 Zn finger	538..558	CDD:275368	7/20 (35%)
		C2H2 Zn finger	566..586	CDD:275368
		C2H2 Zn finger	594..614	CDD:275368
		C2H2 Zn finger	622..642	CDD:275368
		C2H2 Zn finger	650..670	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100