DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8301 and Zfp184

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	XP_003751758.1	Gene:	Zfp184 / 306966	RGDID:	1304798	Length:	739	Species:	Rattus norvegicus

Alignment Length:	643	Identity:	169/643 - (26%)
Similarity:	250/643 - (38%)	Gaps:	137/643 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 NWNLKISPNDGLPQKICSDCFTKFCSINAFRLACQEAQLKLSHIY--DKIDASSLEDDEIGQEDL 109
            :|  ||.|.:               |::...|...|..|....:.  .|.|..|||..:..|:.|
  Rat   100 DW--KIRPEN---------------SVSPLELDISEEHLSSETVVTNSKRDDGSLEKLQANQQTL 147

  Fly   110 EPAEEHQETETTKPTTTVSAETQPNNTAS--DPIEIFVDAVDIDEAEEEEEEEEQQQQYDE--EV 170
            .     :|.:.|:.|...|.|.....:|.  ...:|.||....:...::.....|:::..:  |.
  Rat   148 P-----REVKITEKTMRPSYEKDLGVSAGLLTQTDIAVDQTSTNTRAKQSSRPGQKEKLCKCNEC 207

  Fly   171 EEPITDESA--PPQLTIS----YACKFCLRP---QEN-------------YQLQQL--------- 204
            .:..|..||  ..|.|.:    |.|..|.:.   .||             |:..|.
  Rat   208 GKAFTYCSALIRHQRTHTGEKPYKCNDCNKAFSRNENLINHQRIHTGDKPYKCDQCGKGFIEGPS 272

  Fly   205 LLEHINASHDPEQPYNCPECEARFQDAASRTVHLKSSHVEKQHACGVCGKKYGDRHNLRHHVEKY 269
            |.:| ...|..|:||.|.||...|........|.:....||.:.|..|||.:..|.:...|.:.:
  Rat   273 LTQH-QRIHTGEKPYKCDECGKAFSQRTHLVQHQRIHTGEKPYTCNECGKSFSQRGHFMEHQKIH 336

  Fly   270 HSETDFECALCEKRFYTRKSLNYHMKWHNPDRQFKCR------------------HSG------- 309
            ..|..|:|..|||.|.....|..|.|.|..::.:||.                  |:|
  Rat   337 TGEKPFKCEECEKTFTRSTHLTQHQKIHTGEKTYKCNECGKAFNGPSTFIRHHMIHTGEKPYECN 401

  Fly   310 -CERLFISQRHLMCHEATHSGTSSRKSEHCGFCGKTFIHLKTLRWHIYRQHGGEKPYKCANCTEV 373
             |.:.|....:|..|:.||:|   .|...|..|||.|.:..:|..|: :.|.|||||||::|.:.
  Rat   402 ECGKAFSQHSNLTQHQKTHTG---EKPYDCAECGKAFSYWSSLAQHL-KIHTGEKPYKCSDCGKA 462

  Fly   374 FASYA-----EKRIHM-------------------LERHRENLTAIERSECMLCRQPFSSEPDLI 414
            | ||.     .:|||.                   |.:|::..|..:..||..|.:.|.....|.
  Rat   463 F-SYCSSLTQHRRIHTREKPFECSECGKAFSYLSNLNQHQKTHTQEKAYECKECGKAFIRSSSLA 526

  Fly   415 HHMSAEHLQRP------------GAPIIANNKRVLQQKRERQYSGLFQCGSCSQRFNMKSALERH 467
            .|......::|            |:.:|.:.|   ....||.|    :|..|.:.||.|..|.:|
  Rat   527 KHERIHTGEKPYQCLECGKTFSYGSSLIQHKK---IHTGERPY----KCNECERAFNQKIHLTQH 584

  Fly   468 AAVHSEKDRPHACPHCSKRFKRAQDMKWHIKTHEKEKPNVCDVCGKAFALKYVLTQHRLSHEVLE 532
            ..:|:.. :|:|||.|.|.|:....:..|.|||.:.|...|:.|.|.|:.|..||||:..| :.|
  Rat   585 KRIHTGV-KPYACPKCGKTFRHCSSLAQHQKTHTEGKHYQCNKCEKTFSQKSHLTQHQQVH-MGE 647

  Fly   533 KNFKCNVCGRAYLFEKSLRLHQRTHTGKTYYKCDLCQERFVTHIKLKTHMQKAHAASQ 590
            |.:|||.|.|.:.....|..||..|||:..|..::|.:.|..:..|..| ||.|:..:
  Rat   648 KPYKCNDCDRCFTQSTHLTEHQSIHTGEKPYSSNVCPQTFNQNTYLTQH-QKIHSGEK 704

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071	8/39 (21%)
		COG5048	198..>508	CDD:227381	103/393 (26%)
		C2H2 Zn finger	221..241	CDD:275368	5/19 (26%)
		C2H2 Zn finger	249..269	CDD:275368	6/19 (32%)
		C2H2 Zn finger	277..297	CDD:275368	8/19 (42%)
		C2H2 Zn finger	305..327	CDD:275368	7/47 (15%)
		C2H2 Zn finger	338..359	CDD:275368	7/20 (35%)
		C2H2 Zn finger	367..384	CDD:275368	7/21 (33%)
		C2H2 Zn finger	400..420	CDD:275368	5/19 (26%)
		C2H2 Zn finger	451..471	CDD:275368	7/19 (37%)
		C2H2 Zn finger	480..500	CDD:275368	7/19 (37%)
		C2H2 Zn finger	508..528	CDD:275368	9/19 (47%)
		C2H2 Zn finger	537..557	CDD:275368	7/19 (37%)
		C2H2 Zn finger	565..582	CDD:275368	3/16 (19%)
Zfp184	XP_003751758.1	KRAB	28..88	CDD:214630
		COG5048	203..635	CDD:227381	117/445 (26%)
		C2H2 Zn finger	204..224	CDD:275368	5/19 (26%)
		C2H2 Zn finger	232..252	CDD:275368	4/19 (21%)
		C2H2 Zn finger	260..280	CDD:275368	3/20 (15%)
		C2H2 Zn finger	288..308	CDD:275368	5/19 (26%)
		C2H2 Zn finger	316..336	CDD:275368	6/19 (32%)
		C2H2 Zn finger	344..364	CDD:275368	8/19 (42%)
		C2H2 Zn finger	372..392	CDD:275368	1/19 (5%)
		C2H2 Zn finger	400..420	CDD:275368	4/19 (21%)
		C2H2 Zn finger	428..448	CDD:275368	7/20 (35%)
		C2H2 Zn finger	456..476	CDD:275368	6/20 (30%)
		C2H2 Zn finger	484..504	CDD:275368	2/19 (11%)
		C2H2 Zn finger	512..532	CDD:275368	5/19 (26%)
		C2H2 Zn finger	540..560	CDD:275368	3/22 (14%)
		C2H2 Zn finger	568..588	CDD:275368	7/19 (37%)
		C2H2 Zn finger	596..616	CDD:275368	7/19 (37%)
		C2H2 Zn finger	624..644	CDD:275368	9/19 (47%)
		C2H2 Zn finger	652..672	CDD:275368	7/19 (37%)
		C2H2 Zn finger	680..700	CDD:275368	6/20 (30%)
		C2H2 Zn finger	708..728	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100