DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8301 and Zfp68

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	XP_038945327.1	Gene:	Zfp68 / 304337	RGDID:	1310463	Length:	624	Species:	Rattus norvegicus

Alignment Length:	643	Identity:	144/643 - (22%)
Similarity:	231/643 - (35%)	Gaps:	178/643 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 NNSHFLDLHHPNCWPSEMAQIRLQFANWNLKISPNDGLPQKICSDCFTKFCSINAFRLACQEAQL 85
            |.|:.|.|.|....|..:..:..:..:|.::.| :..:|.      |.|..::|.     ...:.
  Rat    74 NYSNLLFLGHCKTKPELIFNLEQRLGSWIVEAS-HQSIPD------FQKVNTLNE-----TSPET 126

  Fly    86 KLSHIYDKIDASSLEDDE---IGQEDLEPAEEHQETETTKPTTTVSAETQPNNTASD-------- 139
            |..|:. ::..:|...:|   ||.                 |.|||.....|.|...
  Rat   127 KARHVC-QVPLNSDTSEELAGIGN-----------------TCTVSTNCFSNQTVKSEDSLGMSP 173

  Fly   140 -PIEIFVDAV---DIDEAEEEEEEEEQQQQYDEEVEEPITDESAPPQLTI-----SYACKFCLRP 195
             ...::.|..   |:||.|..||        .:::...:.....|.::::     |......|.|
  Rat   174 RKFTLWKDVYLHNDVDEVEVGEE--------PDDLNGTVKSVRHPERVSLYRFQSSQGYFQSLIP 230

  Fly   196 QENYQLQQLLLEH----------------------------INAS---------------HDPEQ 217
            .:::..:.:||.|                            .|.|               |:.|:
  Rat   231 GKSFNTKAVLLTHKFNEYAKSLVDTAFIGKEMAQIRVKSFECNVSEIKCNKSDLNENDPVHEGEK 295

  Fly   218 PYNCPECEARFQDAASRTVHLKSSH----VEKQHACGVCGKKYGDRHNLRHHVEKYHSETDFECA 278
            .|.|.:.|..|...:....| |..|    |:|       |.::..:..:..|.:....:..:||.
  Rat   296 HYKCSDFENPFIIESYLPKH-KGQHEKLFVQK-------GYEFSQQSEVSLHQKIRRGKKTYECK 352

  Fly   279 LCEKRFYTRKSLNYHMKWHNPDRQFKCRHSGCERLFISQRHLMCHEATHSGTSSRKSEHCGFCGK 343
            :|.|.||.:.|.|.|...|..::.::|  :.|.:.|..:.||..|:..|:|   .:...|..|.|
  Rat   353 ICGKCFYWKTSFNRHQSTHTGEKPYEC--TECSKAFCQKSHLTQHQRVHTG---ERPYICFECRK 412

  Fly   344 TFIHLKTLRWHIYRQHGGEKPYKCANCTEVFASYAEKRIHMLERHRENLTAIERSECMLCRQPFS 408
            .|.....|..| .|.|.|||||:|..|.:.|                            |:
  Rat   413 AFYRKSELTDH-QRIHTGEKPYECKECGKAF----------------------------CQ---- 444

  Fly   409 SEPDLIHHMSAEHLQRPGAPIIANNKRVLQQKRERQYSGLFQCGSCSQRFNMKSALERHAAVHSE 473
             :|.|..|......::|                       ::|..|.:.|:.||.|..|...|:
  Rat   445 -KPQLTLHQRIHTGEKP-----------------------YECAECGKAFSTKSYLTVHQRTHT- 484

  Fly   474 KDRPHACPHCSKRFKRAQDMKWHIKTHEKEKPNVCDVCGKAFALKYVLTQHRLSHEVLEKNFKCN 538
            .::|:.|..|.|.|........|.:||..|||..|..|.|.|..|..||:|:.:| ..:|.::|.
  Rat   485 GEKPYECTVCRKSFICKSSFSHHWRTHTGEKPYECKQCMKTFYRKSGLTRHQRTH-TGDKRYECQ 548

  Fly   539 VCGRAYLFEKSLRLHQRTHTGKTYYKCDLCQERFVTHIKLKTHMQKAHAASQPHSADQ 596
            :|.:|:.....|.:|||||||:..|:|..|::.|.....||.| ||.|.|.:.....|
  Rat   549 LCQKAFYCTSHLIVHQRTHTGEKPYECKECRKAFYDKSNLKRH-QKIHTAKKASECKQ 605

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071	12/65 (18%)
		COG5048	198..>508	CDD:227381	76/356 (21%)
		C2H2 Zn finger	221..241	CDD:275368	5/19 (26%)
		C2H2 Zn finger	249..269	CDD:275368	2/19 (11%)
		C2H2 Zn finger	277..297	CDD:275368	8/19 (42%)
		C2H2 Zn finger	305..327	CDD:275368	6/21 (29%)
		C2H2 Zn finger	338..359	CDD:275368	7/20 (35%)
		C2H2 Zn finger	367..384	CDD:275368	3/16 (19%)
		C2H2 Zn finger	400..420	CDD:275368	4/19 (21%)
		C2H2 Zn finger	451..471	CDD:275368	7/19 (37%)
		C2H2 Zn finger	480..500	CDD:275368	5/19 (26%)
		C2H2 Zn finger	508..528	CDD:275368	8/19 (42%)
		C2H2 Zn finger	537..557	CDD:275368	7/19 (37%)
		C2H2 Zn finger	565..582	CDD:275368	5/16 (31%)
Zfp68	XP_038945327.1	KRAB	42..102	CDD:214630	6/27 (22%)
		COG5048	<325..507	CDD:227381	55/251 (22%)
		C2H2 Zn finger	327..343	CDD:275368	2/15 (13%)
		C2H2 Zn finger	351..371	CDD:275368	8/19 (42%)
		C2H2 Zn finger	379..399	CDD:275368	6/21 (29%)
		C2H2 Zn finger	407..427	CDD:275368	7/20 (35%)
		C2H2 Zn finger	435..455	CDD:275368	7/52 (13%)
		C2H2 Zn finger	463..483	CDD:275368	7/19 (37%)
		C2H2 Zn finger	491..511	CDD:275368	5/19 (26%)
		C2H2 Zn finger	519..539	CDD:275368	8/19 (42%)
		zf-H2C2_2	532..554	CDD:404364	7/22 (32%)
		COG5048	545..>618	CDD:227381	23/62 (37%)
		C2H2 Zn finger	547..567	CDD:275368	7/19 (37%)
		C2H2 Zn finger	575..595	CDD:275368	8/20 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100