DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8301 and Zkscan5

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_001100589.1	Gene:	Zkscan5 / 304275	RGDID:	1311175	Length:	822	Species:	Rattus norvegicus

Alignment Length:	763	Identity:	178/763 - (23%)
Similarity:	261/763 - (34%)	Gaps:	251/763 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 HHPNCWPSEMA-----QIRLQFANWNLKISPNDGLPQKICSDCFTKFCSINAF----RLACQEAQ 84
            |||......:|     |..|:.....:...| :.||||:.....|:..|.:.|    ..:.||.|
  Rat   111 HHPESGEEAVAVIESIQRELEERRQQIVTCP-EVLPQKMVPPGATQESSSHQFLPVEAQSDQEPQ 174

  Fly    85 ---------------------------------LKLSHIYDKID-ASSLEDDEIG-----QEDLE 110
                                             .||..|.|..| |.|...:|.|     |:.|.
  Rat   175 NLLEENALPVLQVPSVPLKDSQEPTASLLSAGPQKLVKIEDVADVAVSFILEEWGHLDQSQKSLS 239

  Fly   111 PAEEHQETETTKPTTTVSAETQPNNTASDPIEIFV----DAVDID-EAEEEEEEEEQQQQYDEEV 170
            .....::.|.|.|   |..|.:..|     :|:.|    ||||.. .|.|..|:...|.|...||
  Rat   240 RDGRKEDCERTTP---VDYEPKEGN-----LELVVQQVSDAVDPHWVAAESTEQNSVQPQESAEV 296

  Fly   171 EE-----------PITDESAPPQLTIS----------------YAC----KFCLRPQENYQLQQL 204
            .:           | |..:..|:.::|                :.|    ||.|:.....|.:::
  Rat   297 SDLKDTVQRWQVNP-TWRNPRPKRSLSSGLDVNRKQKSNGERGHRCGDCGKFFLQASNFIQHRRI 360

  Fly   205 LLEHINASHDPEQPYNCPECEARFQDAASRTVHLKSSHVEKQHACGVCGKKYG-DRHNLRHHVEK 268
                    |..|:|:.|.||...:......|.|.:....||.:.|.||||.:. ..|.::||  .
  Rat   361 --------HTGEKPFKCGECGKSYNQRVHLTQHQRVHTGEKPYKCQVCGKAFRVSSHLVQHH--S 415

  Fly   269 YHS-ETDFECALCEKRFYTRKSLNYHMKWHNPDRQFKC--RHSGCERLFISQ------------- 317
            .|| |..:.|:.|.|.|.....|..|:|.|..::..:|  |.|...:|.:.|
  Rat   416 VHSGERPYGCSECGKSFGRHSHLIEHLKRHFREKSQRCSDRRSKDTKLNVQQIPGLSEADVEPSG 480

  Fly   318 --RHLMCHEATHS---------------------GTSSRK-------------------SEHCGF 340
              :...|....||                     |.||.|                   ...|..
  Rat   481 EVQRNACEAEGHSEGCEYQDGAGGQEGVIMKETLGQSSSKRTDCNELSYVHKKPSPGERPHKCNE 545

  Fly   341 CGKTFIHLKTLRWHIYRQHGGEKPYKCANCTEVFASYAEKRIHMLERHRENLTAIERSECMLCRQ 405
            |||:||....|..| .|.|.||||::|..|.:   || .:|:|:.:.||.: |..:...|.||.:
  Rat   546 CGKSFIQSAHLVQH-RRIHTGEKPFRCEECGK---SY-NQRVHLTQHHRVH-TGEKPYACHLCGK 604

  Fly   406 PFSSEPDLIHHMSAEHLQRPGAPIIANNKRVLQQKRERQYSGLFQCGSCSQRFNMKSALERHAAV 470
            .|.....|:.|.|....:||                       |:|..|.:.|..:|.|..|..:
  Rat   605 AFRVRSHLVQHQSVHSRERP-----------------------FKCNECGKGFGRRSHLAGHLRL 646

  Fly   471 HSEKDRPHACPHCSKRFKRAQDM----------------------KWHIKTHEKEK--------P 505
            || :|:.|.|..|.:.|.|...:                      .|::...|.:|        |
  Rat   647 HS-RDKSHQCHECGEIFFRYVSLLEHQMLHVGQKSGNNSVCEEAHSWNLTVMEDKKLELQGEQSP 710

  Fly   506 NVCDVCGKAFALKYVLTQHRLSHEVLE---------------------------KNFKCNVCGRA 543
            ..||.|||||:....|.||..:|...:                           |:.:|:.|||.
  Rat   711 YQCDTCGKAFSYTSDLIQHYRAHSAEKPQKCDACRDSTSQCPHRRQPQKICPSGKSHQCSECGRG 775

  Fly   544 YLFEKSLRLHQRTHTGKTYYKCDLCQERFVTHIKLKTHMQKAHAASQP 591
            :..:..|..|||.|||:..::|..|..:|.....|..|: ::|..:.|
  Rat   776 FGLKSHLSQHQRVHTGEKPFQCKECGMKFSWSCSLLKHL-RSHERTDP 822

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071	17/99 (17%)
		COG5048	198..>508	CDD:227381	93/398 (23%)
		C2H2 Zn finger	221..241	CDD:275368	5/19 (26%)
		C2H2 Zn finger	249..269	CDD:275368	8/20 (40%)
		C2H2 Zn finger	277..297	CDD:275368	7/19 (37%)
		C2H2 Zn finger	305..327	CDD:275368	6/38 (16%)
		C2H2 Zn finger	338..359	CDD:275368	9/20 (45%)
		C2H2 Zn finger	367..384	CDD:275368	5/16 (31%)
		C2H2 Zn finger	400..420	CDD:275368	7/19 (37%)
		C2H2 Zn finger	451..471	CDD:275368	6/19 (32%)
		C2H2 Zn finger	480..500	CDD:275368	5/41 (12%)
		C2H2 Zn finger	508..528	CDD:275368	10/19 (53%)
		C2H2 Zn finger	537..557	CDD:275368	8/19 (42%)
		C2H2 Zn finger	565..582	CDD:275368	4/16 (25%)
Zkscan5	NP_001100589.1	SCAN	45..153	CDD:128708	11/42 (26%)
		SCAN	45..132	CDD:280241	6/20 (30%)
		KRAB	218..248	CDD:279668	7/29 (24%)
		COG5048	320..747	CDD:227381	109/466 (23%)
		C2H2 Zn finger	341..361	CDD:275368	5/27 (19%)
		zf-H2C2_2	353..378	CDD:290200	7/32 (22%)
		C2H2 Zn finger	369..389	CDD:275368	5/19 (26%)
		zf-H2C2_2	381..404	CDD:290200	9/22 (41%)
		C2H2 Zn finger	397..417	CDD:275368	8/21 (38%)
		C2H2 Zn finger	425..445	CDD:275368	7/19 (37%)
		zf-C2H2	541..563	CDD:278523	9/22 (41%)
		C2H2 Zn finger	543..563	CDD:275368	9/20 (45%)
		zf-H2C2_2	555..580	CDD:290200	12/29 (41%)
		C2H2 Zn finger	571..591	CDD:275368	8/23 (35%)
		zf-H2C2_2	583..606	CDD:290200	7/23 (30%)
		C2H2 Zn finger	599..619	CDD:275368	7/19 (37%)
		C2H2 Zn finger	627..647	CDD:275368	6/19 (32%)
		C2H2 Zn finger	655..675	CDD:275368	4/19 (21%)
		C2H2 Zn finger	713..733	CDD:275368	10/19 (53%)
		C2H2 Zn finger	769..789	CDD:275368	8/19 (42%)
		zf-H2C2_2	781..805	CDD:290200	9/23 (39%)
		C2H2 Zn finger	797..817	CDD:275368	5/20 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100