DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8301 and Zfp287

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_001100478.1	Gene:	Zfp287 / 303212	RGDID:	1308617	Length:	762	Species:	Rattus norvegicus

Alignment Length:	642	Identity:	163/642 - (25%)
Similarity:	257/642 - (40%)	Gaps:	151/642 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 EMAQIRLQFANWNLKISPNDGLPQKICSDCFTKFCSINAFRLACQEAQLKLSHIYDKIDASSLED 101
            ::|||..:.|      ..|..|||:|..:              ..:..|:...:.|.:...|:..
  Rat   126 DLAQILEEEA------PQNSALPQEIPEE--------------DPKHALETGWLNDLVTKESVTF 170

  Fly   102 DEIG----QEDLE---PAEEHQETETT---------------KPTTT----------------VS 128
            :::.    |||.|   |.|:......|               :||..                .|
  Rat   171 NDVAVDITQEDWELMRPVEKELYKTVTLQNYWNMVSLGLTVYRPTVIPILEEPWMVIKEIVEGPS 235

  Fly   129 AETQPNNTASDPIEIF-------VDAVDIDEAEEEEEEEEQQQQY-------DEEVEEPITDESA 179
            .|.:....|..|::.|       ...:.::|:.:.|:..|:|..|       ||:      |.|.
  Rat   236 PEWETKAQACSPLKDFPKLKQDGTQTIKLEESCDCEDGLERQPAYAFRKIHIDED------DFSL 294

  Fly   180 PPQLTISYACKFCLRP----QENYQLQQLLLEHINASHDP------------------------- 215
            ..:|:.....:.||..    ::|::....|:...:...|.
  Rat   295 KSELSQEDPTEECLSKYDLYRDNFEKHTNLIIQFDTQSDSKTLLYNESKPTFTNVSSGGVVHGKI 359

  Fly   216 ---EQPYNCPECEARFQDAASRTVHLKSSHVEKQHACGVCGKKYGDRHNLRHHVEKYHSETDFEC 277
               ::||:|..|..:|:...|...|..:...:|.:.|..|||::....:|..|...:..|..:||
  Rat   360 LPGDKPYSCNVCGKKFRKYPSLLAHRNNHAKDKSYECEECGKEFKHLSSLIAHQRMHTGEKPYEC 424

  Fly   278 ALCEKRFYTRKSLNYHMKWHNPDRQFKCRHSGCERLFISQRHLMCHEATHSGTSSRKSEHCGFCG 342
            ..|.|.|..|..|..|.:.|..::.:||  :.|.:.|..:.||..|:.||:|   .|...|..|.
  Rat   425 HQCGKAFSQRAHLTIHQRIHTGEKPYKC--NDCGKDFSQRAHLTIHQRTHTG---EKPYKCLECS 484

  Fly   343 KTFIHLKTLRWHIYRQHGGEKPYKCANCTEVFASYAEKRIHMLERHRENLTAIERSECMLCRQPF 407
            |||.|..:|..| .|.|.|||||.|..|.:.|:    :..|:|: |::..|..:..:|..|.:.|
  Rat   485 KTFSHSSSLINH-QRVHTGEKPYICNECGKTFS----QSTHLLQ-HQKIHTGKKPYKCNECWKVF 543

  Fly   408 SSEPDLIHHMSAEHLQRPGAPIIANNKRVLQQKRERQYSG--LFQCGSCSQRFNMKSALERHAAV 470
            |....||.|                         :|.:||  .::|..|.:.|...|.|.:|...
  Rat   544 SQSTYLIRH-------------------------QRIHSGEKCYKCTECGKAFAHSSTLIQHQTT 583

  Fly   471 HSEKDRPHACPHCSKRFKRAQDMKWHIKTHEKEKPNVCDVCGKAFALKYVLTQHRLSHEVLEKNF 535
            |: .::.:.|..|.|.|.::.::..|.:||..|||..|.||||||:....||||:..|.. ||.|
  Rat   584 HT-GEKSYICNVCGKAFSQSANLTQHHRTHTGEKPYKCSVCGKAFSQSVHLTQHQRIHNG-EKPF 646

  Fly   536 KCNVCGRAYLFEKSLRLHQRTHTGKTYYKCDLCQERFVTHIKLKTHMQKAHAASQPH 592
            |||.||:||....:|..|||.|||:..|||..|.:.|:....|..| ::.|...:|:
  Rat   647 KCNTCGKAYRQGANLTQHQRVHTGEKPYKCHHCGKAFIYSSSLNQH-RRTHTGERPY 702

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071	10/49 (20%)
		COG5048	198..>508	CDD:227381	87/339 (26%)
		C2H2 Zn finger	221..241	CDD:275368	5/19 (26%)
		C2H2 Zn finger	249..269	CDD:275368	6/19 (32%)
		C2H2 Zn finger	277..297	CDD:275368	7/19 (37%)
		C2H2 Zn finger	305..327	CDD:275368	6/21 (29%)
		C2H2 Zn finger	338..359	CDD:275368	9/20 (45%)
		C2H2 Zn finger	367..384	CDD:275368	3/16 (19%)
		C2H2 Zn finger	400..420	CDD:275368	7/19 (37%)
		C2H2 Zn finger	451..471	CDD:275368	6/19 (32%)
		C2H2 Zn finger	480..500	CDD:275368	5/19 (26%)
		C2H2 Zn finger	508..528	CDD:275368	11/19 (58%)
		C2H2 Zn finger	537..557	CDD:275368	10/19 (53%)
		C2H2 Zn finger	565..582	CDD:275368	4/16 (25%)
Zfp287	NP_001100478.1	SCAN	46..133	CDD:280241	3/6 (50%)
		KRAB	168..225	CDD:214630	9/56 (16%)
		KRAB	168..207	CDD:279668	7/38 (18%)
		C2H2 Zn finger	368..388	CDD:275368	5/19 (26%)
		zf-C2H2	394..416	CDD:278523	6/21 (29%)
		C2H2 Zn finger	396..416	CDD:275368	6/19 (32%)
		zf-H2C2_2	408..433	CDD:290200	8/24 (33%)
		COG5048	420..752	CDD:227381	107/322 (33%)
		C2H2 Zn finger	424..444	CDD:275368	7/19 (37%)
		zf-H2C2_2	436..461	CDD:290200	7/26 (27%)
		C2H2 Zn finger	452..472	CDD:275368	6/21 (29%)
		zf-H2C2_2	464..489	CDD:290200	12/27 (44%)
		C2H2 Zn finger	480..500	CDD:275368	9/20 (45%)
		zf-H2C2_2	492..517	CDD:290200	12/29 (41%)
		C2H2 Zn finger	508..528	CDD:275368	6/24 (25%)
		zf-H2C2_2	520..545	CDD:290200	7/25 (28%)
		C2H2 Zn finger	536..556	CDD:275368	8/44 (18%)
		zf-H2C2_2	548..573	CDD:290200	9/49 (18%)
		C2H2 Zn finger	564..584	CDD:275368	6/19 (32%)
		zf-C2H2	590..612	CDD:278523	5/21 (24%)
		C2H2 Zn finger	592..612	CDD:275368	5/19 (26%)
		zf-H2C2_2	604..629	CDD:290200	13/24 (54%)
		C2H2 Zn finger	620..640	CDD:275368	11/19 (58%)
		zf-H2C2_2	632..657	CDD:290200	15/25 (60%)
		C2H2 Zn finger	648..668	CDD:275368	10/19 (53%)
		zf-H2C2_2	660..685	CDD:290200	12/24 (50%)
		C2H2 Zn finger	676..696	CDD:275368	5/20 (25%)
		zf-H2C2_2	688..713	CDD:290200	4/16 (25%)
		C2H2 Zn finger	704..724	CDD:275368
		zf-H2C2_2	717..741	CDD:290200
		C2H2 Zn finger	732..752	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100