DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8301 and Zfp39

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_001100474.2	Gene:	Zfp39 / 303173	RGDID:	1306633	Length:	717	Species:	Rattus norvegicus

Alignment Length:	589	Identity:	143/589 - (24%)
Similarity:	222/589 - (37%)	Gaps:	155/589 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 ETCR---TCAISMFVCD--FENGSNNSHFLDLHHPNCWPSEMAQIRLQFANWNLKISPNDGLPQK 61
            :.||   ||:......:  |.....:|.|.:....   |.|:| :..|..:|..|.:..
  Rat   246 QCCRQEATCSTKALWTNKGFHVAHRSSKFSESEKA---PDEVA-LNAQEMSWVCKETFE------ 300

  Fly    62 ICSDCFTKFCSINAFRL-------------ACQEAQLKLSHIYDKIDASSLEDDEI----GQEDL 109
             ||.|...||:  .|:|             .|::.:...      |:.|..:|..|    |....
  Rat   301 -CSICKETFCT--KFKLTKHKKIHKGQKYFTCRDCEKTF------INTSYHKDQRIHVGVGSHRY 356

  Fly   110 EPAEE--HQETETTKPTTTVSAETQPNNTASDPIEIFVDAVDIDEAEEEEEEEEQQQQYDEEVEE 172
            :..|.  ||:.:.:...:                        :.:..:..|..:.:|.:.|:
  Rat   357 KQCENCFHQKNQQSVHQS------------------------VPKGSKLYEMYQSEQSFSEK--- 394

  Fly   173 PITDESAPPQLTI---------SYACKFCLRPQENYQLQQLLLEHINASHDPEQPYNCPECEARF 228
                    |.|..         .|.|..|   .:::..:..|..| ...|..|:||.|.||:..|
  Rat   395 --------PNLRCCQKTRAGYKPYRCNMC---GKSFYRKSHLSRH-QRIHTGERPYGCKECKKAF 447

  Fly   229 QDAASRTVHLKSSHVEKQHACGVCGKKYGDRHNLRHHVEKYHSETDFECALCEKRFYTRKSLNYH 293
            ...:|.|:|.::...||.:.|..|.|.:..:.:|..|...:..|..:||..|.|.||::..|..|
  Rat   448 FHKSSLTIHQRTHTGEKPYECKKCRKTFYCKSDLNVHHRTHTGEKPYECDECRKTFYSKSHLIIH 512

  Fly   294 MKWHNPDRQFKCRHSGCERLFISQRHLMCHEATHSGTSSRKSEHCGFCGKTFIHLKTLRWHIYRQ 358
            .|.|..|:.::|:.  |::.|..:.:|..|:.||:|   .|...|..|||||.....|..| ...
  Rat   513 RKIHTGDKPYECQE--CQKTFNRKSNLTVHQKTHTG---EKPYECDVCGKTFHRQSHLSMH-QGI 571

  Fly   359 HGGEKPYKCANCTEVFASYAEKRIHMLERHRENLTAIERSECMLCRQPFSSEPDLIHHMSAEHLQ 423
            |.|||||||..|.:.|...:.     |.||:.|.|.                            .
  Rat   572 HSGEKPYKCKECGKAFYQKSS-----LSRHQRNHTG----------------------------D 603

  Fly   424 RPGAPIIANNKRVLQQKRERQYSGLFQCGSCSQRFNMKSALERHAAVHSEKDRPHACPHCSKRFK 488
            ||                       :.|..|.:.|..||:|..|...|:.. :|::|..|.|.|.
  Rat   604 RP-----------------------YACEECRKTFLHKSSLTVHQRSHTGY-KPYSCEECRKTFY 644

  Fly   489 RAQDMKWHIKTHEKEKPNVCDVCGKAFALKYVLTQHRLSHEVLEKNFKCNVCGRAYLFEKSLRLH 553
            ....:..|.:||..|||..|.:|.|||..|..|::|:::|| .||.|:|..|.:.:..:.||.:|
  Rat   645 SKSHLTVHQRTHTGEKPYECKLCRKAFHQKSYLSRHQITHE-REKRFECQECRKRFYHKSSLTVH 708

  Fly   554 QRTH 557
            ||.|
  Rat   709 QRIH 712

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071	21/101 (21%)
		COG5048	198..>508	CDD:227381	85/309 (28%)
		C2H2 Zn finger	221..241	CDD:275368	7/19 (37%)
		C2H2 Zn finger	249..269	CDD:275368	5/19 (26%)
		C2H2 Zn finger	277..297	CDD:275368	8/19 (42%)
		C2H2 Zn finger	305..327	CDD:275368	5/21 (24%)
		C2H2 Zn finger	338..359	CDD:275368	8/20 (40%)
		C2H2 Zn finger	367..384	CDD:275368	3/16 (19%)
		C2H2 Zn finger	400..420	CDD:275368	0/19 (0%)
		C2H2 Zn finger	451..471	CDD:275368	7/19 (37%)
		C2H2 Zn finger	480..500	CDD:275368	5/19 (26%)
		C2H2 Zn finger	508..528	CDD:275368	8/19 (42%)
		C2H2 Zn finger	537..557	CDD:275368	7/19 (37%)
		C2H2 Zn finger	565..582	CDD:275368
Zfp39	NP_001100474.2	KRAB	59..118	CDD:214630
		KRAB	59..98	CDD:279668
		COG5048	296..697	CDD:227381	125/518 (24%)
		C2H2 Zn finger	301..321	CDD:275368	7/21 (33%)
		C2H2 Zn finger	329..348	CDD:275368	4/24 (17%)
		zf-C2H2	410..432	CDD:278523	5/25 (20%)
		C2H2 Zn finger	412..432	CDD:275368	4/23 (17%)
		C2H2 Zn finger	440..460	CDD:275368	7/19 (37%)
		zf-H2C2_2	452..475	CDD:290200	8/22 (36%)
		C2H2 Zn finger	468..488	CDD:275368	5/19 (26%)
		zf-H2C2_2	480..503	CDD:290200	7/22 (32%)
		C2H2 Zn finger	496..516	CDD:275368	8/19 (42%)
		C2H2 Zn finger	524..544	CDD:275368	5/21 (24%)
		zf-H2C2_2	536..561	CDD:290200	12/27 (44%)
		C2H2 Zn finger	552..572	CDD:275368	8/20 (40%)
		zf-H2C2_2	564..587	CDD:290200	11/23 (48%)
		C2H2 Zn finger	580..600	CDD:275368	6/24 (25%)
		C2H2 Zn finger	608..628	CDD:275368	7/19 (37%)
		C2H2 Zn finger	636..656	CDD:275368	5/19 (26%)
		zf-H2C2_2	648..673	CDD:290200	11/24 (46%)
		C2H2 Zn finger	664..684	CDD:275368	8/19 (42%)
		C2H2 Zn finger	692..712	CDD:275368	7/19 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000