DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8301 and ZNF775

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_775951.2	Gene:	ZNF775 / 285971	HGNCID:	28501	Length:	537	Species:	Homo sapiens

Alignment Length:	521	Identity:	130/521 - (24%)
Similarity:	197/521 - (37%)	Gaps:	140/521 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   156 EEEEEEQQQQYDEEVEEPITDESAPPQLTISYACKFCLRPQENYQLQQLLLEHINASHDPEQPYN 220
            |:::|...||:          ...||:.|:.       ||:.           :....:...|..
Human    38 EKDKENIFQQH----------RGLPPRQTMG-------RPRA-----------LGGQEESGSPRW 74

  Fly   221 CPECEARFQDA---------ASRTVHLKSSHVEKQHACGVCGKKYGDRHNLRHHVEKYHSETDFE 276
            .|..|   |||         ||..:....|..|....|..|||::....:|:.|...:..|..:.
Human    75 APPTE---QDAGLAGRAPGSASGPLSPSLSSGEGHFVCLDCGKRFSWWSSLKIHQRTHTGEKPYL 136

  Fly   277 CALCEKRFYTRKSLNYHMKWHNPDRQFKCRHSGCERLFISQRHLMCHEATHSGTSSRKSEH-CGF 340
            |..|.|.|..:.:|..|.:.|..:|.|.|..  |.|.|..::||:.|:.||    ||.:.| |..
Human   137 CGKCGKSFSQKPNLARHQRHHTGERPFCCPE--CARRFSQKQHLLKHQKTH----SRPATHSCPE 195

  Fly   341 CGKTFIHLKTLRWHIYRQHGGEKPYKCANCTEVFASYAEKRIHMLE----RHRENLTAIERSECM 401
            |.:.|.|...||.| .|.|..::....|...|:....|.:|...|:    |.|.     |.:...
Human   196 CERCFRHQVGLRIH-QRAHARDRQGSRAGLHELIQDAAARRACRLQPGPPRGRP-----EWAWLG 254

  Fly   402 LCRQPFSSEPDLIHHMSAEHLQRPGAP--IIAN--------------NKRVLQQKRERQYSGLFQ 450
            || |.:..:|.....:|..  :.||.|  .|.|              ::|:  ...||.|:
Human   255 LC-QGWWGQPGARAAVSGP--EGPGEPRQFICNECGKSFTWWSSLNIHQRI--HTGERPYA---- 310

  Fly   451 CGSCSQRFNMKSALERHAAVHSEKDRPHACPHCSKRFKRAQDMKWHIKTH---EKEKPNVCDVCG 512
            |..|.:||:.|..|.||...|: .:|||.||||.:.|::.|.:..|::||   .:..|  |..||
Human   311 CPECGRRFSQKPNLTRHLRNHT-GERPHPCPHCGRGFRQKQHLLKHLRTHLPGAQAAP--CPSCG 372

  Fly   513 KAFALKYVLTQHRLSHEVLE--------------------------------------------- 532
            |:...:..|..|:.:|.|.|
Human   373 KSCRSRAALRAHQRAHAVAEPAVPAGEPGDQPQAEAIPGLAARPRSSQRSPGARDTLWGRGQAGL 437

  Fly   533 ------KNFKCNVCGRAYLFEKSLRLHQRTHTGKTYYKCDLCQERFVTHIKLKTHMQKAHAASQP 591
                  :.|.||.||:::.:..:|.:|||.|||:..|.|..|..||.....|..| ::.|...:|
Human   438 AGPGEPRQFICNECGKSFSWWSALTIHQRIHTGERPYPCPECGRRFSQKPNLTRH-RRNHTGERP 501

  Fly   592 H 592
            :
Human   502 Y 502

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071
		COG5048	198..>508	CDD:227381	91/342 (27%)
		C2H2 Zn finger	221..241	CDD:275368	7/28 (25%)
		C2H2 Zn finger	249..269	CDD:275368	6/19 (32%)
		C2H2 Zn finger	277..297	CDD:275368	6/19 (32%)
		C2H2 Zn finger	305..327	CDD:275368	7/21 (33%)
		C2H2 Zn finger	338..359	CDD:275368	8/20 (40%)
		C2H2 Zn finger	367..384	CDD:275368	4/16 (25%)
		C2H2 Zn finger	400..420	CDD:275368	5/19 (26%)
		C2H2 Zn finger	451..471	CDD:275368	8/19 (42%)
		C2H2 Zn finger	480..500	CDD:275368	7/19 (37%)
		C2H2 Zn finger	508..528	CDD:275368	6/19 (32%)
		C2H2 Zn finger	537..557	CDD:275368	8/19 (42%)
		C2H2 Zn finger	565..582	CDD:275368	5/16 (31%)
ZNF775	NP_775951.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	39..100		16/91 (18%)
		C2H2 Zn finger	109..129	CDD:275368	6/19 (32%)
		zf-H2C2_2	121..146	CDD:290200	7/24 (29%)
		COG5048	<133..220	CDD:227381	30/93 (32%)
		C2H2 Zn finger	137..157	CDD:275368	6/19 (32%)
		zf-H2C2_2	149..174	CDD:290200	9/26 (35%)
		C2H2 Zn finger	165..185	CDD:275368	7/21 (33%)
		C2H2 Zn finger	193..213	CDD:275368	8/20 (40%)
		COG5048	275..>524	CDD:227381	61/238 (26%)
		C2H2 Zn finger	283..303	CDD:275368	2/21 (10%)
		zf-H2C2_2	295..320	CDD:290200	8/30 (27%)
		C2H2 Zn finger	311..331	CDD:275368	8/19 (42%)
		zf-H2C2_2	323..348	CDD:290200	12/25 (48%)
		C2H2 Zn finger	339..359	CDD:275368	7/19 (37%)
		C2H2 Zn finger	368..388	CDD:275368	6/19 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	386..437		3/50 (6%)
		C2H2 Zn finger	448..468	CDD:275368	8/19 (42%)
		zf-H2C2_2	460..485	CDD:290200	12/24 (50%)
		C2H2 Zn finger	476..496	CDD:275368	6/20 (30%)
		zf-H2C2_2	488..513	CDD:290200	4/16 (25%)
		C2H2 Zn finger	504..524	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100