DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8301 and ZNF454

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_001171560.1	Gene:	ZNF454 / 285676	HGNCID:	21200	Length:	522	Species:	Homo sapiens

Alignment Length:	482	Identity:	135/482 - (28%)
Similarity:	201/482 - (41%)	Gaps:	107/482 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   152 EAEEEEEEEEQQQQYDEEVEEPITDESAPPQLTISYACKFCLRPQ---ENYQLQQLLLEHIN--- 210
            :||..|||.:|.     .::|..:..|       .:.|...|..|   :...||:::|.|.|
Human    97 KAEIPEEELDQW-----TIKERFSSSS-------HWKCASLLEWQCGGQEISLQRVVLTHPNTPS 149

  Fly   211 ------------ASHDPE----QP----YNCPECEARFQDA--------------ASRTVHLKSS 241
                        :.|..:    ||    :.|.||...|..:              |::.:|:|
Human   150 QECDESGSTMSSSLHSDQSQGFQPSKNAFECSECGKVFSKSSTLNKHQKIHNEKNANQKIHIK-- 212

  Fly   242 HVEKQHACGVCGKKYGDRHNLRHHVEKYHSETDFECALCEKRFYTRKSLNYHMKWHNPDRQFKCR 306
              ||::.|..|||.:....:|.||...:..|..:||..|.|.|....||.||.|.|..::.|:|
Human   213 --EKRYECRECGKAFHQSTHLIHHQRIHTGEKPYECKECGKAFSVSSSLTYHQKIHTGEKPFEC- 274

  Fly   307 HSGCERLFISQRHLMCHEATHSGTSSRKSEHCGFCGKTFIHLKTLRWHIYRQ---HGGEKPYKCA 368
             :.|.:.||...||..|...|:|   .|...|..|.|.|:    .|.|:.:.   |.|||||||.
Human   275 -NLCGKAFIRNIHLAHHHRIHTG---EKPFKCNICEKAFV----CRAHLTKHQNIHSGEKPYKCN 331

  Fly   369 NCTEVF---ASYAE-KRIHMLERHRENLTAIERSECMLCRQPFSSEPDLIHHMSAEHLQRPGAPI 429
            .|.:.|   .|:.: :|||         |..:..||..|.:.|.....|..|......::|
Human   332 ECGKAFNQSTSFLQHQRIH---------TGEKPFECNECGKAFRVNSSLTEHQRIHTGEKP---- 383

  Fly   430 IANNKRVLQQKRERQYSGLFQCGSCSQRFNMKSALERHAAVHSEKDRPHACPHCSKRFKRAQDMK 494
                               ::|..|.:.|...|:..||..:|: .::|:.|..|.|.|:....:.
Human   384 -------------------YKCNECGKAFRDNSSFARHRKIHT-GEKPYRCGLCEKAFRDQSALA 428

  Fly   495 WHIKTHEKEKPNVCDVCGKAFALKYVLTQHRLSHEVLEKNFKCNVCGRAYLFEKSLRLHQRTHTG 559
            .|.:.|..|||..|::|.|||:....||||:..| ..||.:||.:|.:|::....|..|||.|||
Human   429 QHQRIHTGEKPYTCNICEKAFSDHSALTQHKRIH-TREKPYKCKICEKAFIRSTHLTQHQRIHTG 492

  Fly   560 KTYYKCDLCQERFVTHIKLKTHMQKAH 586
            :..|||:.|.:.|.....|..| |:.|
Human   493 EKPYKCNKCGKAFNQTANLIQH-QRHH 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071
		COG5048	198..>508	CDD:227381	92/353 (26%)
		C2H2 Zn finger	221..241	CDD:275368	7/33 (21%)
		C2H2 Zn finger	249..269	CDD:275368	7/19 (37%)
		C2H2 Zn finger	277..297	CDD:275368	9/19 (47%)
		C2H2 Zn finger	305..327	CDD:275368	7/21 (33%)
		C2H2 Zn finger	338..359	CDD:275368	6/23 (26%)
		C2H2 Zn finger	367..384	CDD:275368	6/20 (30%)
		C2H2 Zn finger	400..420	CDD:275368	5/19 (26%)
		C2H2 Zn finger	451..471	CDD:275368	6/19 (32%)
		C2H2 Zn finger	480..500	CDD:275368	5/19 (26%)
		C2H2 Zn finger	508..528	CDD:275368	9/19 (47%)
		C2H2 Zn finger	537..557	CDD:275368	7/19 (37%)
		C2H2 Zn finger	565..582	CDD:275368	4/16 (25%)
ZNF454	NP_001171560.1	KRAB	14..73	CDD:214630
		KRAB	14..53	CDD:279668
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	147..170		1/22 (5%)
		zf-C2H2	178..200	CDD:278523	4/21 (19%)
		C2H2 Zn finger	180..200	CDD:275368	4/19 (21%)
		COG5048	186..522	CDD:227381	113/381 (30%)
		C2H2 Zn finger	218..238	CDD:275368	7/19 (37%)
		zf-H2C2_2	230..254	CDD:290200	8/23 (35%)
		C2H2 Zn finger	246..266	CDD:275368	9/19 (47%)
		zf-H2C2_2	258..283	CDD:290200	10/26 (38%)
		C2H2 Zn finger	274..294	CDD:275368	7/21 (33%)
		zf-H2C2_2	286..311	CDD:290200	10/31 (32%)
		C2H2 Zn finger	302..322	CDD:275368	6/23 (26%)
		zf-H2C2_2	314..339	CDD:290200	11/24 (46%)
		C2H2 Zn finger	330..350	CDD:275368	5/19 (26%)
		zf-H2C2_2	342..365	CDD:290200	8/31 (26%)
		C2H2 Zn finger	358..378	CDD:275368	5/19 (26%)
		zf-H2C2_2	370..393	CDD:290200	5/45 (11%)
		C2H2 Zn finger	386..406	CDD:275368	6/19 (32%)
		zf-H2C2_2	398..421	CDD:290200	7/23 (30%)
		C2H2 Zn finger	414..434	CDD:275368	5/19 (26%)
		zf-H2C2_2	426..450	CDD:290200	9/23 (39%)
		C2H2 Zn finger	442..462	CDD:275368	9/19 (47%)
		zf-H2C2_2	454..479	CDD:290200	11/25 (44%)
		C2H2 Zn finger	470..490	CDD:275368	7/19 (37%)
		zf-H2C2_2	482..507	CDD:290200	12/24 (50%)
		C2H2 Zn finger	498..518	CDD:275368	6/20 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100