DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8301 and ZFP82

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_001308846.1	Gene:	ZFP82 / 284406	HGNCID:	28682	Length:	533	Species:	Homo sapiens

Alignment Length:	593	Identity:	165/593 - (27%)
Similarity:	241/593 - (40%)	Gaps:	108/593 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 MAQIRLQFANWNLKISPND----GLPQK-ICSDCFTKFCSINAFRLA-CQEAQLKLSHIYDKIDA 96
            ||...:.|::.::..||.:    .|.|| :..|...:..| |...|| |         ...|.|.
Human     1 MALRSVMFSDVSIDFSPEEWEYLDLEQKDLYRDVMLENYS-NLVSLAGC---------FISKPDV 55

  Fly    97 -SSLEDDEIGQEDLEPAEEHQETETTKPTTTVSAETQPNNTASDPIEIFVDAVDIDEAEEE---- 156
             ||||..:      ||.:..::.....|......||:..:..:|..||.:....|.|..|.
Human    56 ISSLEQGK------EPWKVVRKGRRQYPDLETKYETKKLSLENDIYEINLSQWKIMERIENHGLK 114

  Fly   157 --------------EEEEEQQQQYDEEVEEPITDESAPPQLTI------------SYACKFCLRP 195
                          |.:|..|:.|...|:.|....|:..:.|.            .|.||.|
Human   115 GLILKNDWESTGKIEGQERPQEGYFSSVKMPSEKVSSYQKRTSVTPHQRLHFVDKPYECKEC--- 176

  Fly   196 QENYQLQQLLLEHINASHDPEQPYNCPECEARFQDAASRTVHLKSSHVEKQHACGVCGKKYGDRH 260
            .:.::::|.|..| :..|..|:||.|.||...|:..|..|.|.:....||.:.|..||:.:....
Human   177 GKAFRVRQQLTFH-HRIHTGEKPYECKECGMAFRQTAHLTRHQRLHSGEKLYECKECGEAFICGA 240

  Fly   261 NLRHHVEKYHSETDFECALCEKRFYTRKSLNYHMKWHNPDRQFKCRHSGCERLFISQRHLMCHEA 325
            :||.|.:.:..|..:||..|.|.|..|..|..|.:.|..::.:.|:.  |.:.|....||..|:.
Human   241 DLRVHQKMHIGEKPYECKECGKAFRVRGQLTLHQRIHTGEKPYVCKE--CGKAFRQYAHLTRHQK 303

  Fly   326 THSGTSSRKSEHCGFCGKTFIHLKTLRWHIYRQHGGEKPYKCANCTEVFASYAEKRIHMLERHRE 390
            .:|  :.|..| |..|||.|:....||.| ::.|.|||||:|..|.:.|            |.|:
Human   304 LNS--ADRLYE-CKECGKAFLCGSGLRVH-HKLHTGEKPYECKECGKAF------------RVRQ 352

  Fly   391 NLTAIER-------SECMLCRQPFSSEPDLIHHMSAEHLQRPGAPIIANNKRVLQQKRERQYSGL 448
            .||..:|       .||..|.:.||....||.|......::|
Human   353 QLTLHQRIHTGEKPYECKECGKTFSRGYHLILHHRIHTGEKP----------------------- 394

  Fly   449 FQCGSCSQRFNMKSALERHAAVHSEKDRPHACPHCSKRFKRAQDMKWHIKTHEKEKPNVCDVCGK 513
            ::|..|.:.|:..|.|..|.::|... :|:.|..|.|.|:....:..|...|..|||..|..|||
Human   395 YECKECWKAFSRYSQLISHQSIHIGV-KPYDCKECGKAFRLLSQLTQHQSIHIGEKPYKCKECGK 458

  Fly   514 AFALKYVLTQHRLSHEVLEKNFKCNVCGRAYLFEKSLRLHQRTHTGKTYYKCDLCQERFVTHIKL 578
            ||.|:..||.|:..| ..||.|:|..|.:|:....||..|.|.|:|:..|:|..|::.|..|..|
Human   459 AFRLRQKLTLHQSIH-TGEKPFECKECRKAFRLNSSLIQHLRIHSGEKPYECKECKKAFRQHSHL 522

  Fly   579 KTHMQKAH 586
             ||..|.|
Human   523 -THHLKIH 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071	14/54 (26%)
		COG5048	198..>508	CDD:227381	89/316 (28%)
		C2H2 Zn finger	221..241	CDD:275368	7/19 (37%)
		C2H2 Zn finger	249..269	CDD:275368	6/19 (32%)
		C2H2 Zn finger	277..297	CDD:275368	7/19 (37%)
		C2H2 Zn finger	305..327	CDD:275368	6/21 (29%)
		C2H2 Zn finger	338..359	CDD:275368	8/20 (40%)
		C2H2 Zn finger	367..384	CDD:275368	3/16 (19%)
		C2H2 Zn finger	400..420	CDD:275368	7/19 (37%)
		C2H2 Zn finger	451..471	CDD:275368	6/19 (32%)
		C2H2 Zn finger	480..500	CDD:275368	5/19 (26%)
		C2H2 Zn finger	508..528	CDD:275368	10/19 (53%)
		C2H2 Zn finger	537..557	CDD:275368	7/19 (37%)
		C2H2 Zn finger	565..582	CDD:275368	6/16 (38%)
ZFP82	NP_001308846.1	KRAB	6..66	CDD:214630	19/75 (25%)
		COG5048	144..527	CDD:227381	127/430 (30%)
		C2H2 Zn finger	173..193	CDD:275368	6/23 (26%)
		C2H2 Zn finger	201..221	CDD:275368	7/19 (37%)
		C2H2 Zn finger	229..249	CDD:275368	6/19 (32%)
		C2H2 Zn finger	257..277	CDD:275368	7/19 (37%)
		C2H2 Zn finger	285..304	CDD:275368	6/20 (30%)
		C2H2 Zn finger	313..333	CDD:275368	8/20 (40%)
		C2H2 Zn finger	341..361	CDD:275368	8/31 (26%)
		C2H2 Zn finger	369..389	CDD:275368	7/19 (37%)
		C2H2 Zn finger	397..417	CDD:275368	6/19 (32%)
		C2H2 Zn finger	425..445	CDD:275368	5/19 (26%)
		C2H2 Zn finger	453..473	CDD:275368	10/19 (53%)
		C2H2 Zn finger	481..501	CDD:275368	7/19 (37%)
		C2H2 Zn finger	509..529	CDD:275368	8/20 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100