DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8301 and ZNF283

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_862828.1	Gene:	ZNF283 / 284349	HGNCID:	13077	Length:	679	Species:	Homo sapiens

Alignment Length:	679	Identity:	161/679 - (23%)
Similarity:	268/679 - (39%)	Gaps:	150/679 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 MAQIRLQFANWNLKISPNDGLPQKIC---------SDCFTKFCSINAFRLACQEAQLKLSH--IY 91
            :||..:|:.:.....:|..|.....|         |..|:.||:          :.::.||  :.
Human     6 VAQAGVQWCDLGSLQAPPPGFTLFSCLSLLSSWDYSSGFSGFCA----------SPIEESHGALI 60

  Fly    92 DKIDASSLEDD---------EIGQED---LEPAEE--HQETETTKPTTTVSAETQPNNTASDPIE 142
            ...::.::.|.         :..||:   |:||:.  :.:......:..||.:.:.....:..|.
Human    61 SSCNSRTMTDGLVTFRDVAIDFSQEEWECLDPAQRDLYVDVMLENYSNLVSLDLESKTYETKKIF 125

  Fly   143 IFVDAVDIDEAEEEEEEEEQQQQYD----------EEVEEPIT--DESAPPQLTISYACKFCLRP 195
            ...|..:|:.::.|.:::.:....:          :.:.|.:.  .|....|:.|||      ..
Human   126 SENDIFEINFSQWEMKDKSKTLGLEASIFRNNWKCKSIFEGLKGHQEGYFSQMIISY------EK 184

  Fly   196 QENYQLQQLLLEHINASHDPEQPYNCPECEARFQDAASRTVHLKSSHVEKQHACGVCGKKYGDRH 260
            ..:|:..:.|..| ...|:.|:.|.|.||.......:....|.::...||...|..|||.|...:
Human   185 IPSYRKSKSLTPH-QRIHNTEKSYVCKECGKACSHGSKLVQHERTHTAEKHFECKECGKNYLSAY 248

  Fly   261 NLRHHVEKYHS-ETDFECALCEKRFYTRKSLNYHMKWHNPDRQFKCRHSGCERLFISQRHLMCHE 324
            .|..| :::|: |..:||..|.|.|....||..|.:.|..::.::|:.  |.:.|....||..|:
Human   249 QLNVH-QRFHTGEKPYECKECGKTFSWGSSLVKHERIHTGEKPYECKE--CGKAFSRGYHLTQHQ 310

  Fly   325 ATHSGTSSRKSEHCGFCGKTFIHLKTLRWHIYRQHGGEKPYKCANCTEVFASYAEKRIHMLERHR 389
            ..|:|..|.|   |..|||.|....:|..|.. .|.|||||||..|.:.|:     |.:.|.:|:
Human   311 KIHTGVKSYK---CKECGKAFFWGSSLAKHEI-IHTGEKPYKCKECGKAFS-----RGYQLTQHQ 366

  Fly   390 ENLTAIERSECMLCRQPFSSEPDLIHHMSAEHLQRP------------GAPIIANNKRVLQQK-- 440
            :..|..:..||.:|.:.|.....|..|......::|            |:.:|.:.:....:|
Human   367 KIHTGKKPYECKICGKAFCWGYQLTRHQIFHTGEKPYECKECGKAFNCGSSLIQHERIHTGEKPY 431

  Fly   441 -----------------RERQYSG--LFQCGSCSQRFNMKSALERHAAVHS-EK----------- 474
                             .::.::|  .|:|..|.:.|:..|:|.:|..||: ||
Human   432 ECKECGKAFSRGYHLSQHQKIHTGEKPFECKECGKAFSWGSSLVKHERVHTGEKSHECKECGKTF 496

  Fly   475 ---------------DRPHACPHCSKRFKRAQDMKWHIKTHEKEKPNVCDVCGKAFALKYVLTQH 524
                           ::|:.|..|.|.|.....:..|.:.|..|||..|..|||||:..|.||||
Human   497 CSGYQLTRHQVFHTGEKPYECKECGKAFNCGSSLVQHERIHTGEKPYECKECGKAFSRGYHLTQH 561

  Fly   525 RLSHEVLEKNFKCNVCGRAYLFEKSLRLHQRTHTGKTYYKCDLCQERFVTHIKLKTHMQKAHAA- 588
            :..| ..||.|||..||:|:.:..||..|:|.||.:..|:|..|.:.|.:..:|..| |:.|..
Human   562 QKIH-TGEKPFKCKECGKAFSWGSSLVKHERVHTNEKSYECKDCGKAFGSGYQLSVH-QRFHTGE 624

  Fly   589 --------------------SQPHSADQP 597
                                .:.||.|:|
Human   625 KLYQRKEFGKTFTCGSKLVHERTHSNDKP 653

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071	10/57 (18%)
		COG5048	198..>508	CDD:227381	93/370 (25%)
		C2H2 Zn finger	221..241	CDD:275368	4/19 (21%)
		C2H2 Zn finger	249..269	CDD:275368	7/19 (37%)
		C2H2 Zn finger	277..297	CDD:275368	7/19 (37%)
		C2H2 Zn finger	305..327	CDD:275368	6/21 (29%)
		C2H2 Zn finger	338..359	CDD:275368	7/20 (35%)
		C2H2 Zn finger	367..384	CDD:275368	4/16 (25%)
		C2H2 Zn finger	400..420	CDD:275368	5/19 (26%)
		C2H2 Zn finger	451..471	CDD:275368	6/19 (32%)
		C2H2 Zn finger	480..500	CDD:275368	5/19 (26%)
		C2H2 Zn finger	508..528	CDD:275368	11/19 (58%)
		C2H2 Zn finger	537..557	CDD:275368	8/19 (42%)
		C2H2 Zn finger	565..582	CDD:275368	4/16 (25%)
ZNF283	NP_862828.1	KRAB	72..113	CDD:307490	7/40 (18%)
		C2H2 Zn finger	209..229	CDD:275368	4/19 (21%)
		C2H2 Zn finger	237..257	CDD:275368	7/20 (35%)
		COG5048	261..655	CDD:227381	110/406 (27%)
		C2H2 Zn finger	265..285	CDD:275368	7/19 (37%)
		C2H2 Zn finger	293..313	CDD:275368	6/21 (29%)
		C2H2 Zn finger	321..341	CDD:275368	7/20 (35%)
		C2H2 Zn finger	349..369	CDD:275368	6/24 (25%)
		C2H2 Zn finger	377..397	CDD:275368	5/19 (26%)
		C2H2 Zn finger	405..425	CDD:275368	2/19 (11%)
		C2H2 Zn finger	433..453	CDD:275368	0/19 (0%)
		C2H2 Zn finger	461..481	CDD:275368	6/19 (32%)
		C2H2 Zn finger	489..509	CDD:275368	0/19 (0%)
		C2H2 Zn finger	517..537	CDD:275368	5/19 (26%)
		C2H2 Zn finger	545..565	CDD:275368	11/19 (58%)
		C2H2 Zn finger	573..593	CDD:275368	8/19 (42%)
		C2H2 Zn finger	601..621	CDD:275368	6/20 (30%)
		C2H2 Zn finger	629..648	CDD:275368	0/18 (0%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100