DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8301 and ZNF547

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_775902.2	Gene:	ZNF547 / 284306	HGNCID:	26432	Length:	402	Species:	Homo sapiens

Alignment Length:	457	Identity:	121/457 - (26%)
Similarity:	180/457 - (39%)	Gaps:	106/457 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   143 IFVD-AVDIDEAEEEEEEEEQQQQYDEEVEEPIT------------DESAPPQLTIS------YA 188
            :|.| |:...:.|....:|.|:..|.:.:.|.:.            ||.||.:..:|      .|
Human    12 VFEDVAIYFSQEEWGHLDEAQRLLYRDVMLENLALLSSLGCCHGAEDEEAPLEPGVSVGVSQVMA 76

  Fly   189 CKFCLRPQENYQLQ--QLLLEHI--NASHD---PEQP-YNCPE----------CEARFQDAASRT 235
            .|.||..|.....:  ..||:.|  .|.||   |||. |.||.          .|...:....|.
Human    77 PKPCLSTQNTQPCETCSSLLKDILRLAEHDGTHPEQGLYTCPAHLHQHQKEQIREKLSRGDGGRP 141

  Fly   236 VHLKSSHVE---KQHACGVCGKKYGDRHNLRHHVEKYHSETDFECALCEKRFYTRKSLNYHMKWH 297
            ..:|:..|.   |...|..|||.:..:|.|..|.:.:..|..::|:.|...|..|.:||.|.:.|
Human   142 TFVKNHRVHMAGKTFLCSECGKAFSHKHKLSDHQKIHTGERTYKCSKCGILFMERSTLNRHQRTH 206

  Fly   298 NPDRQFKCRHSGCERLFISQRHLMCHEATHSGTSSRKSEHCGFCGKTFIHLKTLRWHIYRQHGGE 362
            ..:|.::|..  |.:.|:.:.||:.|:..|||   .:...|..|||.|:...||..| .|.|.|:
Human   207 TGERPYECNE--CGKAFLCKSHLVRHQTIHSG---ERPYECSECGKLFMWSSTLITH-QRVHTGK 265

  Fly   363 KPYKCANCTEVFASYAEKRIHMLERHRENLTAIERSECMLCRQPFSSEPDLIHHMSAEHLQRPGA 427
            :||.|:.|.:.|                        :|         ..:|..|.
Human   266 RPYGCSECGKFF------------------------KC---------NSNLFRHY---------- 287

  Fly   428 PIIANNKRVLQQKRERQYSGLFQCGSCSQRFNMKSALERHAAVHSEKDRPHACPHCSKRFKRAQD 492
                   |:...||.      :.|..|.:.|..:|.|.||..||: .:||:.|..|.|.|.....
Human   288 -------RIHTGKRS------YGCSECGKFFMERSTLSRHQRVHT-GERPYECNECGKFFSLKSV 338

  Fly   493 MKWHIKTHEKEKPNVCDVCGKAFALKYVLTQHRLSHEVLEKNFKCNVCGRAYLFEKSLRLHQRTH 557
            :..|.:.|..|:|..|..|||||..|..|..|:..|...:   :|:.||:.:.:..:|..||:.|
Human   339 LIQHQRVHTGERPYECSECGKAFLTKSHLICHQTVHTAAK---QCSECGKFFRYNSTLLRHQKVH 400

  Fly   558 TG 559
            ||
Human   401 TG 402

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071
		COG5048	198..>508	CDD:227381	84/330 (25%)
		C2H2 Zn finger	221..241	CDD:275368	5/29 (17%)
		C2H2 Zn finger	249..269	CDD:275368	7/19 (37%)
		C2H2 Zn finger	277..297	CDD:275368	7/19 (37%)
		C2H2 Zn finger	305..327	CDD:275368	6/21 (29%)
		C2H2 Zn finger	338..359	CDD:275368	9/20 (45%)
		C2H2 Zn finger	367..384	CDD:275368	3/16 (19%)
		C2H2 Zn finger	400..420	CDD:275368	3/19 (16%)
		C2H2 Zn finger	451..471	CDD:275368	7/19 (37%)
		C2H2 Zn finger	480..500	CDD:275368	5/19 (26%)
		C2H2 Zn finger	508..528	CDD:275368	9/19 (47%)
		C2H2 Zn finger	537..557	CDD:275368	6/19 (32%)
		C2H2 Zn finger	565..582	CDD:275368
ZNF547	NP_775902.2	KRAB	11..66	CDD:214630	12/53 (23%)
		KRAB	11..50	CDD:279668	8/37 (22%)
		COG5048	<156..314	CDD:227381	53/219 (24%)
		C2H2 Zn finger	158..178	CDD:275368	7/19 (37%)
		C2H2 Zn finger	186..206	CDD:275368	7/19 (37%)
		zf-H2C2_2	199..221	CDD:290200	7/23 (30%)
		C2H2 Zn finger	214..234	CDD:275368	6/21 (29%)
		zf-H2C2_2	226..249	CDD:290200	10/25 (40%)
		C2H2 Zn finger	242..262	CDD:275368	9/20 (45%)
		C2H2 Zn finger	270..290	CDD:275368	7/69 (10%)
		C2H2 Zn finger	298..318	CDD:275368	7/19 (37%)
		zf-H2C2_2	311..334	CDD:290200	10/23 (43%)
		C2H2 Zn finger	326..346	CDD:275368	5/19 (26%)
		zf-H2C2_2	339..363	CDD:290200	10/23 (43%)
		C2H2 Zn finger	354..374	CDD:275368	9/19 (47%)
		C2H2 Zn finger	380..400	CDD:275368	6/19 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100