DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG8301 and ZNF547

DIOPT Version :9

Sequence 1:NP_649915.1 Gene:CG8301 / 41160 FlyBaseID:FBgn0037717 Length:607 Species:Drosophila melanogaster
Sequence 2:NP_775902.2 Gene:ZNF547 / 284306 HGNCID:26432 Length:402 Species:Homo sapiens


Alignment Length:457 Identity:121/457 - (26%)
Similarity:180/457 - (39%) Gaps:106/457 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly   143 IFVD-AVDIDEAEEEEEEEEQQQQYDEEVEEPIT------------DESAPPQLTIS------YA 188
            :|.| |:...:.|....:|.|:..|.:.:.|.:.            ||.||.:..:|      .|
Human    12 VFEDVAIYFSQEEWGHLDEAQRLLYRDVMLENLALLSSLGCCHGAEDEEAPLEPGVSVGVSQVMA 76

  Fly   189 CKFCLRPQENYQLQ--QLLLEHI--NASHD---PEQP-YNCPE----------CEARFQDAASRT 235
            .|.||..|.....:  ..||:.|  .|.||   |||. |.||.          .|...:....|.
Human    77 PKPCLSTQNTQPCETCSSLLKDILRLAEHDGTHPEQGLYTCPAHLHQHQKEQIREKLSRGDGGRP 141

  Fly   236 VHLKSSHVE---KQHACGVCGKKYGDRHNLRHHVEKYHSETDFECALCEKRFYTRKSLNYHMKWH 297
            ..:|:..|.   |...|..|||.:..:|.|..|.:.:..|..::|:.|...|..|.:||.|.:.|
Human   142 TFVKNHRVHMAGKTFLCSECGKAFSHKHKLSDHQKIHTGERTYKCSKCGILFMERSTLNRHQRTH 206

  Fly   298 NPDRQFKCRHSGCERLFISQRHLMCHEATHSGTSSRKSEHCGFCGKTFIHLKTLRWHIYRQHGGE 362
            ..:|.::|..  |.:.|:.:.||:.|:..|||   .:...|..|||.|:...||..| .|.|.|:
Human   207 TGERPYECNE--CGKAFLCKSHLVRHQTIHSG---ERPYECSECGKLFMWSSTLITH-QRVHTGK 265

  Fly   363 KPYKCANCTEVFASYAEKRIHMLERHRENLTAIERSECMLCRQPFSSEPDLIHHMSAEHLQRPGA 427
            :||.|:.|.:.|                        :|         ..:|..|.          
Human   266 RPYGCSECGKFF------------------------KC---------NSNLFRHY---------- 287

  Fly   428 PIIANNKRVLQQKRERQYSGLFQCGSCSQRFNMKSALERHAAVHSEKDRPHACPHCSKRFKRAQD 492
                   |:...||.      :.|..|.:.|..:|.|.||..||: .:||:.|..|.|.|.....
Human   288 -------RIHTGKRS------YGCSECGKFFMERSTLSRHQRVHT-GERPYECNECGKFFSLKSV 338

  Fly   493 MKWHIKTHEKEKPNVCDVCGKAFALKYVLTQHRLSHEVLEKNFKCNVCGRAYLFEKSLRLHQRTH 557
            :..|.:.|..|:|..|..|||||..|..|..|:..|...:   :|:.||:.:.:..:|..||:.|
Human   339 LIQHQRVHTGERPYECSECGKAFLTKSHLICHQTVHTAAK---QCSECGKFFRYNSTLLRHQKVH 400

  Fly   558 TG 559
            ||
Human   401 TG 402

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG8301NP_649915.1 zf-AD 3..87 CDD:285071
COG5048 198..>508 CDD:227381 84/330 (25%)
C2H2 Zn finger 221..241 CDD:275368 5/29 (17%)
C2H2 Zn finger 249..269 CDD:275368 7/19 (37%)
C2H2 Zn finger 277..297 CDD:275368 7/19 (37%)
C2H2 Zn finger 305..327 CDD:275368 6/21 (29%)
C2H2 Zn finger 338..359 CDD:275368 9/20 (45%)
C2H2 Zn finger 367..384 CDD:275368 3/16 (19%)
C2H2 Zn finger 400..420 CDD:275368 3/19 (16%)
C2H2 Zn finger 451..471 CDD:275368 7/19 (37%)
C2H2 Zn finger 480..500 CDD:275368 5/19 (26%)
C2H2 Zn finger 508..528 CDD:275368 9/19 (47%)
C2H2 Zn finger 537..557 CDD:275368 6/19 (32%)
C2H2 Zn finger 565..582 CDD:275368
ZNF547NP_775902.2 KRAB 11..66 CDD:214630 12/53 (23%)
KRAB 11..50 CDD:279668 8/37 (22%)
COG5048 <156..314 CDD:227381 53/219 (24%)
C2H2 Zn finger 158..178 CDD:275368 7/19 (37%)
C2H2 Zn finger 186..206 CDD:275368 7/19 (37%)
zf-H2C2_2 199..221 CDD:290200 7/23 (30%)
C2H2 Zn finger 214..234 CDD:275368 6/21 (29%)
zf-H2C2_2 226..249 CDD:290200 10/25 (40%)
C2H2 Zn finger 242..262 CDD:275368 9/20 (45%)
C2H2 Zn finger 270..290 CDD:275368 7/69 (10%)
C2H2 Zn finger 298..318 CDD:275368 7/19 (37%)
zf-H2C2_2 311..334 CDD:290200 10/23 (43%)
C2H2 Zn finger 326..346 CDD:275368 5/19 (26%)
zf-H2C2_2 339..363 CDD:290200 10/23 (43%)
C2H2 Zn finger 354..374 CDD:275368 9/19 (47%)
C2H2 Zn finger 380..400 CDD:275368 6/19 (32%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24377
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
11.100

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