DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG8301 and ZNF311

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	XP_005249076.1	Gene:	ZNF311 / 282890	HGNCID:	13847	Length:	699	Species:	Homo sapiens

Alignment Length:	560	Identity:	150/560 - (26%)
Similarity:	233/560 - (41%)	Gaps:	79/560 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   106 QEDLEP-AEEHQETETTKPTTTVSAETQ--PNNTASDPIEIF---------------VDAVDIDE 152
            :.:::| .::.|:.|:...:..|||:..  .|..||...|||               ||:.|...
Human   150 EREVDPCVQDPQDRESLSCSYPVSADKMWPENEKASSQQEIFENGEAYWMKFNSLLKVDSRDPKV 214

  Fly   153 AEEEEEEEEQQQQYDEEVEEPITDE----------------------------SAPPQLTISYAC 189
            .|...::.:.:.|::..:.|.:.:|                            |...::.|:...
Human   215 REVCVQDVKLENQWETSIREKLREEKEGSEEVTCKKGKNQKVLSKNLNPNSKHSQCNKVLIAQKL 279

  Fly   190 KFCLRPQENYQLQQLLLEHINASHDPEQPYNCPECEARFQDAASRTVHLKSSHVEKQHACGVCGK 254
            ..|.|..:|:.....|:.| ...|..|:|:.|.||...|:.....::|......||...|..|||
Human   280 HECARCGKNFSWHSDLILH-EQIHSGEKPHVCNECGKAFKTRNQLSMHRIIHTGEKPFNCTQCGK 343

  Fly   255 KYGDRHNLRHHVEKYHSETDFECALCEKRFYTRKSLNYHMKWHNPDRQFKCRHSGCERLFISQRH 319
            .:..|..|..|.:.:..|...||..|.|.|.||..|..|...|..::.:||  :.|.:.|..:..
Human   344 AFNSRSALCRHKKTHSGEKPHECRDCGKAFKTRNRLCMHQLIHTGEKPYKC--NCCGKAFQFKHS 406

  Fly   320 LMCHEATHSGTSSRKSEHCGFCGKTFIHLKTLRWHIYRQHGGEKPYKCANCTEVFASYAE----K 380
            |..|...|:|   .|...|..|||.|.....|..|| |.|.||:||:|:.|...|:..::    |
Human   407 LTIHGRIHTG---EKPYECEECGKAFSGSSDLTKHI-RIHTGERPYECSKCGRAFSRSSDLSKHK 467

  Fly   381 RIHMLERHRENLTAIERSECMLCRQPFSSEPDLIHHMSAE------HLQRPGAPIIANNKRVLQQ 439
            |||..|:|         ..|..|.:.||.:.:|..|....      ..:..|.....|.||   :
Human   468 RIHTREKH---------YGCPQCGKDFSIKAELTKHRRIHTEEKRYRCEECGKAFRHNCKR---R 520

  Fly   440 KRERQYSG--LFQCGSCSQRFNMKSALERHAAVHSEKDRPHACPHCSKRFKRAQDMKWHIKTHEK 502
            ..||:::|  .:||..|.:.|..|..|..|..:|: .::|:.|..|.|.|....::..|.:.|..
Human   521 AHEREHTGEKPYQCRDCGKTFQDKHCLTIHQRIHT-GEKPYKCLECGKAFSGKSNLTNHRRIHTG 584

  Fly   503 EKPNVCDVCGKAFALKYVLTQHRLSHEVLEKNFKCNVCGRAYLFEKSLRLHQRTHTGKTYYKCDL 567
            |||:.|:|||.||....||.||:..| ..||.:.|:.||.::....:|..|:|.|||:..|:|:.
Human   585 EKPHKCEVCGMAFHHSSVLRQHKRIH-TGEKPYTCSECGTSFRQGSALIGHKRVHTGEKPYECEE 648

  Fly   568 CQERFVTHIKLKTHMQKAHAASQPHSADQPLDDLINIVIS 607
            |.:.|.....|..|.::.|.....|..|.....|..:.:|
Human   649 CGKAFRVSSNLTGHKKRKHQVWSTHELDGSRKSLSPVTVS 688

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071
		COG5048	198..>508	CDD:227381	94/321 (29%)
		C2H2 Zn finger	221..241	CDD:275368	5/19 (26%)
		C2H2 Zn finger	249..269	CDD:275368	7/19 (37%)
		C2H2 Zn finger	277..297	CDD:275368	8/19 (42%)
		C2H2 Zn finger	305..327	CDD:275368	5/21 (24%)
		C2H2 Zn finger	338..359	CDD:275368	9/20 (45%)
		C2H2 Zn finger	367..384	CDD:275368	6/20 (30%)
		C2H2 Zn finger	400..420	CDD:275368	6/19 (32%)
		C2H2 Zn finger	451..471	CDD:275368	6/19 (32%)
		C2H2 Zn finger	480..500	CDD:275368	5/19 (26%)
		C2H2 Zn finger	508..528	CDD:275368	10/19 (53%)
		C2H2 Zn finger	537..557	CDD:275368	6/19 (32%)
		C2H2 Zn finger	565..582	CDD:275368	4/16 (25%)
ZNF311	XP_005249076.1	KRAB	97..157	CDD:214630	1/6 (17%)
		KRAB	97..136	CDD:279668
		C2H2 Zn finger	282..302	CDD:275368	5/20 (25%)
		zf-H2C2_2	294..319	CDD:290200	9/25 (36%)
		COG5048	306..>633	CDD:227381	106/346 (31%)
		C2H2 Zn finger	310..330	CDD:275368	5/19 (26%)
		zf-H2C2_2	323..347	CDD:290200	7/23 (30%)
		C2H2 Zn finger	338..358	CDD:275368	7/19 (37%)
		zf-H2C2_2	353..375	CDD:290200	7/21 (33%)
		C2H2 Zn finger	366..386	CDD:275368	8/19 (42%)
		C2H2 Zn finger	394..414	CDD:275368	5/21 (24%)
		zf-C2H2	420..442	CDD:278523	9/22 (41%)
		C2H2 Zn finger	422..442	CDD:275368	9/20 (45%)
		zf-H2C2_2	434..459	CDD:290200	12/25 (48%)
		C2H2 Zn finger	450..470	CDD:275368	5/19 (26%)
		C2H2 Zn finger	478..498	CDD:275368	6/19 (32%)
		zf-H2C2_2	490..515	CDD:290200	3/24 (13%)
		C2H2 Zn finger	506..526	CDD:275368	6/22 (27%)
		zf-H2C2_2	520..541	CDD:290200	6/20 (30%)
		C2H2 Zn finger	534..554	CDD:275368	6/19 (32%)
		zf-H2C2_2	547..570	CDD:290200	7/23 (30%)
		C2H2 Zn finger	562..582	CDD:275368	5/19 (26%)
		zf-H2C2_2	574..599	CDD:290200	11/24 (46%)
		C2H2 Zn finger	590..610	CDD:275368	10/19 (53%)
		zf-H2C2_2	603..627	CDD:290200	9/24 (38%)
		C2H2 Zn finger	618..638	CDD:275368	6/19 (32%)
		zf-H2C2_2	634..653	CDD:290200	8/18 (44%)
		C2H2 Zn finger	646..664	CDD:275368	5/17 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	62	1.000	Domainoid score	I10319
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.100