DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8301 and ZNF777

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	XP_005250037.1	Gene:	ZNF777 / 27153	HGNCID:	22213	Length:	875	Species:	Homo sapiens

Alignment Length:	513	Identity:	130/513 - (25%)
Similarity:	210/513 - (40%)	Gaps:	118/513 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    93 KIDASSLEDDEIGQEDLEPAEEHQETETTKPTTTVSAETQPNNTASDPIEIFVD--------AVD 149
            :::....:|.|:|    :|..|..:.:..:|..|:...|:.::..|:..::.|.        .:.
Human   436 QVEEHGFQDSELG----DPCGEQPDLDMQEPENTLEESTEGSSEFSELKQMLVQQRNCTEGIVIK 496

  Fly   150 IDEAEEEEEEEEQQQ-------------QYDEEVEE--------PITDESAPPQLTISYACKFCL 193
            .:|.:|||||||:.:             :|:..:.:        |..:||.||....:.|.|
Human   497 TEEQDEEEEEEEEDELPQHLQSLGQLSGRYEASMYQTPLPGEMSPEGEESPPPLQLGNPAVK--- 558

  Fly   194 RPQENYQLQQLLLEHINASHDP------EQPYNCPECEARFQDAASRTVHLKSSHVEKQHACGVC 252
            |...:...::.|.|:..||...      |:|:.|.|                            |
Human   559 RLAPSVHGERHLSENRGASSQQQRNRRGERPFTCME----------------------------C 595

  Fly   253 GKKYGDRHNLRHHVEKYHSETDFECALCEKRFYTRKSLNYHMKWH-------NPDR--QFKCRHS 308
            ||.:..:.||..|...:..|..:|||.||..|..::.|..|.:.|       :|:|  .|..:|:
Human   596 GKSFRLKINLIIHQRNHIKEGPYECAECEISFRHKQQLTLHQRIHRVRGGCVSPERGPTFNPKHA 660

  Fly   309 GCERLFISQRHLMCHEATHSGTSSRKSEHCGFCGKTFIHLKTLRWHIYRQHGGEKPYKCANCTEV 373
                  :..|..  ..::.||....|...|..|..:|.|..:|..| ...|.||:||.|..|.:.
Human   661 ------LKPRPK--SPSSGSGGGGPKPYKCPECDSSFSHKSSLTKH-QITHTGERPYTCPECKKS 716

  Fly   374 FASYAEKRIHM-LERHRENLTAIERSECMLCRQPFSSEPDLIHHMSAEHLQRPGAPIIANNKRVL 437
            |..:....||. :...:..::.|    |.||.:.||....|:.|......:||
Human   717 FRLHISLVIHQRVHAGKHEVSFI----CSLCGKSFSRPSHLLRHQRTHTGERP------------ 765

  Fly   438 QQKRERQYSGLFQCGSCSQRFNMKSALERHAAVHSEKDRPHACPHCSKRFKRAQDMKWHIKTHEK 502
                       |:|..|.:.|:.||.|..|..||| ::||||||.|.|.|.|...:..|.:.|..
Human   766 -----------FKCPECEKSFSEKSKLTNHCRVHS-RERPHACPECGKSFIRKHHLLEHRRIHTG 818

  Fly   503 EKPNVCDVCGKAFALKYVLTQHRLSHEVLEKNFKCNVCGRAYLFEKSLRLHQRTHTGK 560
            |:|..|..|||.|..|:.|.:|:.:| ..|:.:.|..|.:.:.:::||:.|.|||||:
Human   819 ERPYHCAECGKRFTQKHHLLEHQRAH-TGERPYPCTHCAKCFRYKQSLKYHLRTHTGE 875

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071
		COG5048	198..>508	CDD:227381	83/325 (26%)
		C2H2 Zn finger	221..241	CDD:275368	2/19 (11%)
		C2H2 Zn finger	249..269	CDD:275368	6/19 (32%)
		C2H2 Zn finger	277..297	CDD:275368	7/19 (37%)
		C2H2 Zn finger	305..327	CDD:275368	2/21 (10%)
		C2H2 Zn finger	338..359	CDD:275368	6/20 (30%)
		C2H2 Zn finger	367..384	CDD:275368	4/16 (25%)
		C2H2 Zn finger	400..420	CDD:275368	7/19 (37%)
		C2H2 Zn finger	451..471	CDD:275368	7/19 (37%)
		C2H2 Zn finger	480..500	CDD:275368	7/19 (37%)
		C2H2 Zn finger	508..528	CDD:275368	8/19 (42%)
		C2H2 Zn finger	537..557	CDD:275368	6/19 (32%)
		C2H2 Zn finger	565..582	CDD:275368
ZNF777	XP_005250037.1	KRAB	329..387	CDD:214630
		KRAB_A-box	329..368	CDD:143639
		zf-C2H2	590..612	CDD:278523	8/49 (16%)
		C2H2 Zn finger	592..612	CDD:275368	8/47 (17%)
		zf-H2C2_2	604..629	CDD:290200	10/24 (42%)
		C2H2 Zn finger	620..640	CDD:275368	7/19 (37%)
		CpXC	681..>730	CDD:291051	16/49 (33%)
		C2H2 Zn finger	682..702	CDD:275368	6/20 (30%)
		COG5048	<684..870	CDD:227381	65/215 (30%)
		zf-H2C2_2	694..717	CDD:290200	9/23 (39%)
		C2H2 Zn finger	713..730	CDD:275370	4/16 (25%)
		zf-C2H2	738..760	CDD:278523	8/25 (32%)
		C2H2 Zn finger	740..760	CDD:275368	7/19 (37%)
		zf-H2C2_2	752..776	CDD:290200	7/46 (15%)
		C2H2 Zn finger	768..788	CDD:275368	7/19 (37%)
		zf-H2C2_2	781..805	CDD:290200	14/24 (58%)
		C2H2 Zn finger	796..816	CDD:275368	7/19 (37%)
		zf-H2C2_2	808..833	CDD:290200	9/24 (38%)
		C2H2 Zn finger	824..844	CDD:275368	8/19 (42%)
		zf-H2C2_2	836..861	CDD:290200	6/25 (24%)
		C2H2 Zn finger	852..872	CDD:275368	6/19 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100