DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8301 and Zfp747

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_780769.1	Gene:	Zfp747 / 269997	MGIID:	2443581	Length:	422	Species:	Mus musculus

Alignment Length:	414	Identity:	114/414 - (27%)
Similarity:	167/414 - (40%)	Gaps:	89/414 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   160 EEQQQQYDEEVEEPITDESAPPQLTISYAC---KFCLRPQENYQLQQLLLEHINASHDPEQPYNC 221
            ||:.:.:....::|   |.|..:..:...|   |...||:|..:..|       .:..||.....
Mouse    75 EEESEVWGPGAQDP---EVAMCRTEVHSDCRHEKERKRPREETEAMQ-------KTFSPEPGQKE 129

  Fly   222 PECEARFQDAASRTVHLKSSHVEKQHACGVCGKKYGDRHNLRHHVEKYHSETDFECALCEKRFYT 286
            |:.......:..:...|::   :|:|.|.:|||.:..|..|..|:..:..|..|:|..|.|||..
Mouse   130 PQLSFAVSASGIQATVLRA---DKRHGCHLCGKSFARRSTLEAHMYTHTGEKPFQCPDCNKRFGR 191

  Fly   287 RKSLNYHMKWHNPDRQFKCRHSGCERLFISQRHLMCHEATHSGTSSRKSEHCGFCGKTFIHLKTL 351
            ..||:.|...|..:|..:|..                                 |||.|....||
Mouse   192 YSSLSTHRAIHRGERPHQCPD---------------------------------CGKGFTQRCTL 223

  Fly   352 RWHIYRQHGGEKPYKCANCTEVFASYAEKRIHMLERHRENLTAIERSE----CMLCRQPFSSEPD 412
            ..|:| .|.||||::|.:|.:.|..|:.     |..||    ||.|.|    |..|.:.|:....
Mouse   224 VAHMY-SHTGEKPFQCPDCNKCFGRYSS-----LSMHR----AIHRGERPHQCPDCGKGFTQRCA 278

  Fly   413 LIHHMSAEHLQRPGAPIIANNKRVLQQKRERQYSGLFQCGSCSQRFNMKSALERHAAVHSEKDRP 477
            |:.||.:...::.                       |.|..|.:.|...|:|.||.|:|.| :||
Mouse   279 LVEHMYSHTGEKS-----------------------FNCPDCCKSFGRPSSLSRHRAIHLE-ERP 319

  Fly   478 HACPHCSKRFKRAQDMKWHIKTHEKEKPNVCDVCGKAFALKYVLTQH-RLSHEVLEKNFKCNVCG 541
            |.|.||.|.|.:...:..|::.|..|||..|..||:.|:.:..|.:| |:.|..:.. |.|..||
Mouse   320 HRCSHCGKTFTQRSSLTSHLRVHTGEKPYCCADCGRCFSQRSRLHEHQRVVHSGVTP-FSCTHCG 383

  Fly   542 RAYLFEKSLRLHQRTHTGKTYYKC 565
            .|:...|.||.|.|.|||:..|.|
Mouse   384 SAFADSKYLRRHMRIHTGEKPYSC 407

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071
		COG5048	198..>508	CDD:227381	81/313 (26%)
		C2H2 Zn finger	221..241	CDD:275368	2/19 (11%)
		C2H2 Zn finger	249..269	CDD:275368	7/19 (37%)
		C2H2 Zn finger	277..297	CDD:275368	8/19 (42%)
		C2H2 Zn finger	305..327	CDD:275368	1/21 (5%)
		C2H2 Zn finger	338..359	CDD:275368	8/20 (40%)
		C2H2 Zn finger	367..384	CDD:275368	4/16 (25%)
		C2H2 Zn finger	400..420	CDD:275368	6/19 (32%)
		C2H2 Zn finger	451..471	CDD:275368	8/19 (42%)
		C2H2 Zn finger	480..500	CDD:275368	6/19 (32%)
		C2H2 Zn finger	508..528	CDD:275368	7/20 (35%)
		C2H2 Zn finger	537..557	CDD:275368	9/19 (47%)
		C2H2 Zn finger	565..582	CDD:275368	1/1 (100%)
Zfp747	NP_780769.1	KRAB	22..81	CDD:214630	2/5 (40%)
		KRAB	22..61	CDD:279668
		C2H2 Zn finger	154..174	CDD:275368	7/19 (37%)
		zf-H2C2_2	167..191	CDD:290200	9/23 (39%)
		COG5048	<170..355	CDD:227381	70/251 (28%)
		C2H2 Zn finger	182..202	CDD:275368	8/19 (42%)
		zf-H2C2_2	194..219	CDD:290200	10/57 (18%)
		C2H2 Zn finger	210..230	CDD:275368	9/53 (17%)
		zf-H2C2_2	223..247	CDD:290200	11/24 (46%)
		C2H2 Zn finger	238..258	CDD:275368	8/28 (29%)
		zf-H2C2_2	250..275	CDD:290200	10/33 (30%)
		C2H2 Zn finger	266..286	CDD:275368	6/19 (32%)
		zf-H2C2_2	278..303	CDD:290200	7/47 (15%)
		C2H2 Zn finger	294..314	CDD:275368	8/19 (42%)
		zf-H2C2_2	306..331	CDD:290200	14/25 (56%)
		zf-C2H2	320..342	CDD:278523	7/21 (33%)
		C2H2 Zn finger	322..342	CDD:275368	6/19 (32%)
		zf-H2C2_2	334..359	CDD:290200	9/24 (38%)
		C2H2 Zn finger	350..369	CDD:275368	6/18 (33%)
		C2H2 Zn finger	379..399	CDD:275368	9/19 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100