DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8301 and ZNF549

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_001186224.2	Gene:	ZNF549 / 256051	HGNCID:	26632	Length:	640	Species:	Homo sapiens

Alignment Length:	493	Identity:	135/493 - (27%)
Similarity:	211/493 - (42%)	Gaps:	66/493 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   114 EHQETETTKPTTTVSAET-QPNNTASDPIEIFVDAVDIDEAEEEE--EEEEQQQQYDEE------ 169
            :||.|.:.:.....|.|| |......:  ::|.:.|.:.|.:...  |:..::::|.:.
Human   199 QHQTTHSRQEYAHRSRETFQQRRYKCE--QVFNEKVHVTEHQRVHTGEKAYKRREYGKSLNSKYL 261

  Fly   170 -VEEPITDESAPPQLTISYACKFCLRPQENYQLQQLLLEHINASHDPEQPYNCPECEARFQDAAS 233
             ||...|..:..|     |.|..|   .:::..:|.|:.|....|..|:.|.|.||........|
Human   262 FVEHQRTHNAEKP-----YVCNIC---GKSFLHKQTLVGHQQRIHTRERSYVCIECGKSLSSKYS 318

  Fly   234 RTVHLKSSHVEKQHACGVCGKKYGDRHNLRHHVEKYHS-ETDFECALCEKRFYTRKSLNYHMKWH 297
            ...|.::.:.||.:.|.||||.:..:.....|.::.|: |..:.|..|.|.|........|.:.|
Human   319 LVEHQRTHNGEKPYVCNVCGKSFRHKQTFVGHQQRIHTGERPYVCMECGKSFIHSYDRIRHQRVH 383

  Fly   298 NPDRQFKCRHSGCERLFISQRHLMCHEATHSGTSSRKSEHCGFCGKTFIHLKTLRWHIYRQHGGE 362
            ..:..::|  |.|.:.||.::.|:.|...|:|   .:...|..|||.|||.|.|..| .|.|.||
Human   384 TGEGAYQC--SECGKSFIYKQSLLDHHRIHTG---ERPYECKECGKAFIHKKRLLEH-QRIHTGE 442

  Fly   363 KPYKCANCTEVFASYAE----KRIHMLERHRENLTAIERSECMLCRQPFSSEPDLIHHMSAEHLQ 423
            |||.|..|.:.|...::    :|||..||         ..||..|.:.|.|:..|:.|......:
Human   443 KPYVCIICGKSFIRSSDYMRHQRIHTGER---------AYECSDCGKAFISKQTLLKHHKIHTRE 498

  Fly   424 RPGAPIIANNKRVLQQKRERQYSGLFQCGSCSQRFNMKSALERHAAVHSEKDRPHACPHCSKRFK 488
            ||                       ::|..|.:.|.::..|.:|..:|: :::...|..|.|.|.
Human   499 RP-----------------------YECSECGKGFYLEVKLLQHQRIHT-REQLCECNECGKVFS 539

  Fly   489 RAQDMKWHIKTHEKEKPNVCDVCGKAFALKYVLTQHRLSHEVLEKNFKCNVCGRAYLFEKSLRLH 553
            ..:.:..|.|.|..|||..|..|||.|..:..|.||:..|.. |:.:.|..|.:|::::..|..|
Human   540 HQKRLLEHQKVHTGEKPCECSECGKCFRHRTSLIQHQKVHSG-ERPYNCTACEKAFIYKNKLVEH 603

  Fly   554 QRTHTGKTYYKCDLCQERFVTHIKLKTHMQKAHAASQP 591
            ||.|||:..|:|..|.:.|.....|..| ||.|...:|
Human   604 QRIHTGEKPYECGKCGKAFNKRYSLVRH-QKVHITEEP 640

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071
		COG5048	198..>508	CDD:227381	86/314 (27%)
		C2H2 Zn finger	221..241	CDD:275368	5/19 (26%)
		C2H2 Zn finger	249..269	CDD:275368	6/19 (32%)
		C2H2 Zn finger	277..297	CDD:275368	5/19 (26%)
		C2H2 Zn finger	305..327	CDD:275368	7/21 (33%)
		C2H2 Zn finger	338..359	CDD:275368	11/20 (55%)
		C2H2 Zn finger	367..384	CDD:275368	5/20 (25%)
		C2H2 Zn finger	400..420	CDD:275368	6/19 (32%)
		C2H2 Zn finger	451..471	CDD:275368	5/19 (26%)
		C2H2 Zn finger	480..500	CDD:275368	6/19 (32%)
		C2H2 Zn finger	508..528	CDD:275368	8/19 (42%)
		C2H2 Zn finger	537..557	CDD:275368	7/19 (37%)
		C2H2 Zn finger	565..582	CDD:275368	4/16 (25%)
ZNF549	NP_001186224.2	KRAB	27..67	CDD:307490
		COG5048	223..603	CDD:227381	112/429 (26%)
		C2H2 Zn finger	224..241	CDD:275368	3/18 (17%)
		C2H2 Zn finger	249..269	CDD:275368	3/19 (16%)
		C2H2 Zn finger	277..298	CDD:275368	5/23 (22%)
		C2H2 Zn finger	306..326	CDD:275368	5/19 (26%)
		C2H2 Zn finger	334..355	CDD:275368	6/20 (30%)
		C2H2 Zn finger	363..383	CDD:275368	5/19 (26%)
		C2H2 Zn finger	391..411	CDD:275368	7/21 (33%)
		C2H2 Zn finger	419..439	CDD:275368	11/20 (55%)
		C2H2 Zn finger	447..467	CDD:275368	4/19 (21%)
		C2H2 Zn finger	475..495	CDD:275368	6/19 (32%)
		C2H2 Zn finger	503..523	CDD:275368	5/19 (26%)
		C2H2 Zn finger	531..551	CDD:275368	6/19 (32%)
		C2H2 Zn finger	559..579	CDD:275368	8/19 (42%)
		C2H2 Zn finger	587..607	CDD:275368	7/19 (37%)
		zf-H2C2_2	600..624	CDD:316026	11/23 (48%)
		C2H2 Zn finger	615..635	CDD:275368	7/20 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100