DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8301 and sfc2

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_594670.1	Gene:	sfc2 / 2542887	PomBaseID:	SPAC144.09c	Length:	374	Species:	Schizosaccharomyces pombe

Alignment Length:	375	Identity:	92/375 - (24%)
Similarity:	138/375 - (36%)	Gaps:	70/375 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   252 CGKKYGDRHNLRHHVEKYHSETDFECAL--CEKRFYTRKSLNYHMKWHNPDRQFKCRHSGCERLF 314
            |||||.....|..|:..:.:|..|.|..  |.|.||.:..|..|.:.|...:.|.|.:.||:..|
pombe    30 CGKKYSRPSLLEQHLRTHSNERPFVCDYTGCSKAFYRKSHLKIHKRCHTNVKPFSCHYDGCDAQF 94

  Fly   315 ISQRHLMCHEATHSGTSSRKSEHCGF--CGKTFIHLKTLRWHIYRQHGGEKPYKCA--NCTEVFA 375
            .:|:||..|...|   ...|...|.:  |.:.|...:.||.||...|....||.|.  :|...||
pombe    95 YTQQHLERHIEVH---RKPKPYACTWEGCDECFSKHQQLRSHISACHTHLLPYPCTYQDCELRFA 156

  Fly   376 SYAEKRIHMLERHRENLTAIERSECMLCRQPFSSEPDLIHHMSAEHLQRPGAPIIANNKRVLQQK 440
            :..:.:.|:...|.:.::.....|..:..:.|.....|.:|:...|:.
pombe   157 TKQKLQNHVNRAHEKIISYSCPHESCVGHEGFEKWSQLQNHIREAHVP----------------- 204

  Fly   441 RERQYSGLFQCGSCSQRFNMKSALERHAAVHS---EKDRPHACP--HCSKRFKRAQDMKWHIKT- 499
                     .|..|.::|...:.|..|..:|.   |:.:.:.||  .|.|.|.|:..:|.||..
pombe   205 ---------SCSICGRQFKTAAHLRHHVVLHQTTLEERKTYHCPMEGCKKSFTRSSALKKHISVI 260

  Fly   500 HEKEKPNVCDVCGKAFALKYVLTQHRLSHEVLEKNFK--CNVCGRAYLFEKSLRLHQRTH----- 557
            ||......||.||..|..|::|.:| |.....:|..|  .|.||..:...:.:.:|.:..
pombe   261 HEGNMAFHCDSCGTKFGYKHMLQRH-LERGTCKKAHKPYINECGIKHDGIEGVAIHDQKEKELSS 324

  Fly   558 --------------TGKTY-----YKCDL--CQERFVTHIKLKTHMQKAH 586
                          ||..|     |.|..  |..||.....:..|:...|
pombe   325 NLVSDVAKKIINEVTGHGYKEAREYSCSFPECNYRFKRLYDMHRHLNSHH 374

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071
		COG5048	198..>508	CDD:227381	67/267 (25%)
		C2H2 Zn finger	221..241	CDD:275368
		C2H2 Zn finger	249..269	CDD:275368	7/16 (44%)
		C2H2 Zn finger	277..297	CDD:275368	7/21 (33%)
		C2H2 Zn finger	305..327	CDD:275368	8/21 (38%)
		C2H2 Zn finger	338..359	CDD:275368	7/22 (32%)
		C2H2 Zn finger	367..384	CDD:275368	4/18 (22%)
		C2H2 Zn finger	400..420	CDD:275368	3/19 (16%)
		C2H2 Zn finger	451..471	CDD:275368	5/19 (26%)
		C2H2 Zn finger	480..500	CDD:275368	9/22 (41%)
		C2H2 Zn finger	508..528	CDD:275368	9/19 (47%)
		C2H2 Zn finger	537..557	CDD:275368	4/19 (21%)
		C2H2 Zn finger	565..582	CDD:275368	4/18 (22%)
sfc2	NP_594670.1	COG5048	1..374	CDD:227381	91/373 (24%)
		C2H2 Zn finger	28..47	CDD:275368	7/16 (44%)
		C2H2 Zn finger	55..77	CDD:275368	7/21 (33%)
		C2H2 Zn finger	85..107	CDD:275368	8/21 (38%)
		C2H2 Zn finger	115..138	CDD:275368	7/22 (32%)
		C2H2 Zn finger	146..165	CDD:275368	4/18 (22%)
		C2H2 Zn finger	206..226	CDD:275368	5/19 (26%)
		C2H2 Zn finger	238..261	CDD:275368	9/22 (41%)
		C2H2 Zn finger	269..286	CDD:275368	8/17 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	138	1.000	Inparanoid score	I1382
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.050