DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8301 and Zfp300

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_001345769.1	Gene:	Zfp300 / 245368	MGIID:	3045326	Length:	646	Species:	Mus musculus

Alignment Length:	590	Identity:	154/590 - (26%)
Similarity:	233/590 - (39%)	Gaps:	147/590 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    87 LSHIYDKIDASSLEDDEIGQEDLEPAEEHQETETTKPTTTVSAETQPNNTASDPIEIFVDAVDID 151
            |..|..:|.:||..:|  ||.:...| .||:.:              |......|.|.
Mouse    65 LGIIKREIPSSSCTED--GQAEYNLA-WHQKNQ--------------NMHLEQAISII------- 105

  Fly   152 EAEEEEEEEEQQQQYDEEVEEPITD-----ESAP-PQLTIS------------------------ 186
               |:...||:..:||..| .|::.     .|.| |.:..|
Mouse   106 ---EKNVTEERSYEYDGFV-SPLSQSTWVVSSGPTPYMNNSFGESIKNNLGLVNPSSMSFAAQEC 166

  Fly   187 YACKFC--------------LRPQENYQLQQLLLEHIN--ASHD----PEQPYNCPECE------ 225
            |.|..|              ::.||:....:   |||.  ..||    .::.|.||||.
Mouse   167 YECNRCRKLLIPGRHEISDRMKSQEHNMFGK---EHIYNFVQHDLTQLGDKTYECPECRITLSPS 228

  Fly   226 ------------------ARFQDAASRTVHL---KSSHV-EKQHACGVCGKKYGDRHNLRHHVEK 268
                              ||.::|.:.|.||   ::.|. :|...|..|||.:.:...|..|...
Mouse   229 SFLVVHQITHIGEKPYEWARCREAFNNTAHLSLHQTMHTGDKLFECNECGKSFREESTLHIHQRT 293

  Fly   269 YHSETDFECALCEKRFYTRKSLNYHMKWHNPDRQFKCRHSGCERLFISQRHLMCHEATHSGTSSR 333
            :..|..:.|..|...|..:.:|..|.:.|..::.:||  :.||:.|..:.||..|:.||:|   .
Mouse   294 HTGEKPYICTECGNAFQEKTNLIIHRRTHKGEKPYKC--TDCEKTFNQKAHLNVHQRTHTG---E 353

  Fly   334 KSEHCGFCGKTFIHLKTLRWHIYRQHGGEKPYKCANCTEVFASYAEKRIHMLERHRENLTAIERS 398
            |...|..|||.|....||..| .|.|.|||||.|..|.:.|....:..|     |:...|..:..
Mouse   354 KPFECTNCGKYFREKSTLNIH-QRTHTGEKPYVCNECGKAFREKTKLII-----HQRTHTGEKPY 412

  Fly   399 ECMLCRQPFSSEPDLIHHMSAEHLQRPGAPIIANNKRVLQQKRERQYSGLFQCGSCSQRFNMKSA 463
            ||..|.:.|:.:..|..|......::|                       |:|..|.:.|..||.
Mouse   413 ECSECGRAFNQKAHLSVHQRTHTGEKP-----------------------FECNECGKAFREKST 454

  Fly   464 LERHAAVHSEKDRPHACPHCSKRFKRAQDMKWHIKTHEKEKPNVCDVCGKAFALKYVLTQHRLSH 528
            |.||..:|: .::|:.|..|.:.|.....:..|.:.|..||.:.|.||||.|:.|..|..|:.:|
Mouse   455 LRRHQRIHT-GEKPYVCSECGRAFTLKLSLSAHQRIHTGEKTDGCTVCGKVFSRKSYLMLHQRAH 518

  Fly   529 --EVLEKNFKCNVCGRAYLFEKSLRLHQRTHTGKTYYKCDLCQERFVTHIKLKTHMQKAHAASQP 591
              |.|||:::||.|.:|:|.:..|.:|||.|.|:..|:|::|::.|.....|..| |:.|...:|
Mouse   519 TKERLEKSYECNECDKAFLQKSYLIIHQRVHAGEKPYECNICEKSFSQKSYLIIH-QRIHTGEKP 582

  Fly   592 HSADQ 596
            :..|:
Mouse   583 YQCDK 587

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071	154/590 (26%)
		COG5048	198..>508	CDD:227381	89/343 (26%)
		C2H2 Zn finger	221..241	CDD:275368	10/46 (22%)
		C2H2 Zn finger	249..269	CDD:275368	6/19 (32%)
		C2H2 Zn finger	277..297	CDD:275368	5/19 (26%)
		C2H2 Zn finger	305..327	CDD:275368	7/21 (33%)
		C2H2 Zn finger	338..359	CDD:275368	9/20 (45%)
		C2H2 Zn finger	367..384	CDD:275368	4/16 (25%)
		C2H2 Zn finger	400..420	CDD:275368	5/19 (26%)
		C2H2 Zn finger	451..471	CDD:275368	8/19 (42%)
		C2H2 Zn finger	480..500	CDD:275368	4/19 (21%)
		C2H2 Zn finger	508..528	CDD:275368	9/19 (47%)
		C2H2 Zn finger	537..557	CDD:275368	9/19 (47%)
		C2H2 Zn finger	565..582	CDD:275368	4/16 (25%)
Zfp300	NP_001345769.1	KRAB	8..63	CDD:214630
		C2H2 Zn finger	218..238	CDD:275368	4/19 (21%)
		COG5048	249..594	CDD:227381	112/375 (30%)
		C2H2 Zn finger	249..266	CDD:275368	4/16 (25%)
		C2H2 Zn finger	274..294	CDD:275368	6/19 (32%)
		C2H2 Zn finger	302..322	CDD:275368	5/19 (26%)
		C2H2 Zn finger	330..350	CDD:275368	7/21 (33%)
		C2H2 Zn finger	358..378	CDD:275368	9/20 (45%)
		C2H2 Zn finger	386..406	CDD:275368	5/24 (21%)
		C2H2 Zn finger	414..434	CDD:275368	5/19 (26%)
		C2H2 Zn finger	442..462	CDD:275368	8/19 (42%)
		C2H2 Zn finger	470..490	CDD:275368	4/19 (21%)
		C2H2 Zn finger	498..518	CDD:275368	9/19 (47%)
		C2H2 Zn finger	529..549	CDD:275368	9/19 (47%)
		C2H2 Zn finger	557..577	CDD:275368	6/20 (30%)
		C2H2 Zn finger	585..605	CDD:275368	1/3 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100