DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8301 and Zfp354a

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_434685.1	Gene:	Zfp354a / 24522	RGDID:	2967	Length:	576	Species:	Rattus norvegicus

Alignment Length:	551	Identity:	148/551 - (26%)
Similarity:	218/551 - (39%)	Gaps:	109/551 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   109 LEPAEEHQETETTKP-----------TTTVSAETQPNN------------TASDPIEIFVDAVDI 150
            |:..|:..:.|...|           .||.|.:||.::            .|.:|:.:..:.:.|
  Rat    67 LQQGEDPWQVEKEGPRYFSLGLKCSHRTTKSTQTQDSSFQELIVRKSKRTFAFEPLNMKSENLFI 131

  Fly   151 DEAEEEEE------------------EEEQQQQYDEEVEEPITDESAPPQLTIS--YACKFCLRP 195
            .|.:.||:                  .:..:::...|.::.|:..|.||.:|..  |.|..|
  Rat   132 HEGKLEEKWDKNTLTVERSHKNNEFSPKSHREKRSSECKKQISYLSNPPGITPDKRYKCSMC--- 193

  Fly   196 QENYQLQQLLLEHINASHDPEQPYNCPECEARFQDAASRTVHLKSSHVEKQHACGVCGKKYGDRH 260
            ::.:.....|.:| ..:|..|:.:.|.||...|..:::...|..:...||.:.|..|||.:....
  Rat   194 EKTFINTSSLRKH-EKNHSGEKLFKCKECSKAFSQSSALIQHQITHTGEKPYVCKECGKAFTLST 257

  Fly   261 NLRHHVEKYHSETDFECALCEKRFYTRKSLNYHMKWH--------NPDRQFKCRHSGCERLFISQ 317
            :|..|:..:..|..:.|..|.|.|..|..|..|.|.|        ||.|:.....|||:|....:
  Rat   258 SLYKHLRTHTVEKSYRCKECGKSFGQRSGLFIHQKIHARENPHRYNPGRKASASLSGCQRAHSRK 322

  Fly   318 RHLMC---------------HEATHSGTSSRKSEHCGFCGKTFIHLKTLRWHIYRQHGGEKPYKC 367
            :..:|               |:..|:|   .|...|..||:.|....:|..| .|.|.|||||:|
  Rat   323 KTYLCNECGNTFKSSSSLRYHQRIHTG---EKPFRCSECGRAFSQSASLIQH-ERIHTGEKPYRC 383

  Fly   368 ANCTEVFASYAEKRIHMLERHRENLTAIERSECMLCRQPFSSEPDLIHHMSAEHLQRPGAPIIAN 432
            ..|.:.|.|     |..|.|||...|..:...|..|.:..||...||.|
  Rat   384 GECGKGFTS-----ISRLNRHRIIHTGEKLYNCNECGKALSSHSTLIIH---------------- 427

  Fly   433 NKRVLQQKRERQYSG--LFQCGSCSQRFNMKSALERHAAVHSEKDRPHACPHCSKRFKRAQDMKW 495
                     ||.::|  ..:|..|.:.|...|||.:|..:|: .:||:.|..|.|.|:....:..
  Rat   428 ---------ERIHTGEKPCKCKVCGKAFRQSSALIQHQRMHT-GERPYKCNECGKTFRCNSSLSN 482

  Fly   496 HIKTHEKEKPNVCDVCGKAFALKYVLTQHRLSHEVLEKNFKCNVCGRAYLFEKSLRLHQRTHTGK 560
            |.:.|..|||..|..||.:|.....|.|||..| ..||.||||.||:.:....|...|||.|||:
  Rat   483 HQRIHTGEKPYQCIECGMSFGQSSALIQHRRIH-TGEKPFKCNTCGKTFRQSSSRIAHQRIHTGE 546

  Fly   561 TYYKCDLCQERFVTHIKLKTHMQKAHAASQP 591
            ..|:|:.|.:.|.....|..| .|.|....|
  Rat   547 KPYECNTCGKLFNYRSSLTNH-YKIHVDEDP 576

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071
		COG5048	198..>508	CDD:227381	91/334 (27%)
		C2H2 Zn finger	221..241	CDD:275368	5/19 (26%)
		C2H2 Zn finger	249..269	CDD:275368	6/19 (32%)
		C2H2 Zn finger	277..297	CDD:275368	8/19 (42%)
		C2H2 Zn finger	305..327	CDD:275368	6/36 (17%)
		C2H2 Zn finger	338..359	CDD:275368	7/20 (35%)
		C2H2 Zn finger	367..384	CDD:275368	5/16 (31%)
		C2H2 Zn finger	400..420	CDD:275368	7/19 (37%)
		C2H2 Zn finger	451..471	CDD:275368	7/19 (37%)
		C2H2 Zn finger	480..500	CDD:275368	5/19 (26%)
		C2H2 Zn finger	508..528	CDD:275368	8/19 (42%)
		C2H2 Zn finger	537..557	CDD:275368	8/19 (42%)
		C2H2 Zn finger	565..582	CDD:275368	4/16 (25%)
Zfp354a	NP_434685.1	KRAB	14..74	CDD:214630	2/6 (33%)
		KRAB	14..53	CDD:279668
		COG5048	170..567	CDD:227381	128/436 (29%)
		Nuclear localization signal	170..189		5/18 (28%)
		C2H2 Zn finger	190..210	CDD:275368	4/23 (17%)
		zf-H2C2_2	202..227	CDD:290200	8/25 (32%)
		C2H2 Zn finger	218..238	CDD:275368	5/19 (26%)
		zf-H2C2_2	230..254	CDD:290200	7/23 (30%)
		C2H2 Zn finger	246..266	CDD:275368	6/19 (32%)
		zf-H2C2_2	258..281	CDD:290200	6/22 (27%)
		C2H2 Zn finger	274..294	CDD:275368	8/19 (42%)
		C2H2 Zn finger	327..347	CDD:275368	2/19 (11%)
		zf-H2C2_2	339..364	CDD:290200	8/27 (30%)
		C2H2 Zn finger	355..375	CDD:275368	7/20 (35%)
		zf-H2C2_2	367..392	CDD:290200	12/25 (48%)
		C2H2 Zn finger	383..403	CDD:275368	9/24 (38%)
		C2H2 Zn finger	411..431	CDD:275368	9/44 (20%)
		zf-H2C2_2	424..448	CDD:290200	9/48 (19%)
		C2H2 Zn finger	439..459	CDD:275368	7/19 (37%)
		zf-H2C2_2	451..476	CDD:290200	10/25 (40%)
		C2H2 Zn finger	467..487	CDD:275368	5/19 (26%)
		zf-H2C2_2	479..502	CDD:290200	8/22 (36%)
		C2H2 Zn finger	495..515	CDD:275368	8/19 (42%)
		zf-H2C2_2	507..532	CDD:290200	13/25 (52%)
		C2H2 Zn finger	523..543	CDD:275368	8/19 (42%)
		zf-H2C2_2	539..560	CDD:290200	10/20 (50%)
		C2H2 Zn finger	551..571	CDD:275368	6/20 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100