DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8301 and Zfp324

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_848847.3	Gene:	Zfp324 / 243834	MGIID:	2444641	Length:	583	Species:	Mus musculus

Alignment Length:	493	Identity:	123/493 - (24%)
Similarity:	172/493 - (34%)	Gaps:	141/493 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   109 LEPAEEHQETETTKPTTTVSAETQPNNTASDPIEIFVDAVDIDEAEEEE--EEEEQQQQYDEEVE 171
            |.|.::.:..|..||    ..:..|..|       |....|:..|||..  .|...:.|.|..|.
Mouse   213 LAPGKQPRVAEQRKP----EMQLTPGRT-------FQSIPDLHGAEEGRGMSEAWHESQGDPNVT 266

  Fly   172 EP-ITDESAPPQLTISYACKFCLRPQENYQLQQLLLEHINASHDPEQPYNCPECEARFQDAASRT 235
            |. |.||..                 |..|....||       ..::|:.|..|...|..::...
Mouse   267 EARIWDELG-----------------EALQAGPGLL-------SGDKPFECRACNKVFVKSSDLL 307

  Fly   236 VHLKSSHVEKQHACGVCGKKYGDRHNLRHHVEKYHSETDFECALCEKRFYTRKSLNYHMKWHNPD 300
            .||::...|:.:.|..|||.:....:|..|...:..||.:.|.:|.|.|....||..|.:.|..:
Mouse   308 KHLRTHTGERPYECAQCGKAFSQTSHLTQHQRIHSGETPYVCMVCSKAFRHSSSLVRHQRIHTVE 372

  Fly   301 RQFKCRHSGCERLFISQRHLMCHEATHSGTSSRKSEHCGFCGKTFIHLKTLRWHIYRQHGGEKPY 365
            :.|                                 ||..|||.|.|...|..|: :.|.|.:||
Mouse   373 KSF---------------------------------HCNECGKAFSHGSNLSQHL-KIHAGGRPY 403

  Fly   366 KCANCTEVFASYAEKRIHMLERHRENLTAIERSECMLCRQPFSSEPDLIHHMSAEHLQRPGAPII 430
            .||.|...|                            ||
Mouse   404 ACAQCGRRF----------------------------CR-------------------------- 414

  Fly   431 ANNKRVLQQKRERQYSGLFQCGSCSQRFNMKSALERHAAVHSEKDRPHACPHCSKRFKRAQDMKW 495
              |..::|.:|.......:.|..|...|:..|:|.:|..||: .::|.:||||.:.|..:.::..
Mouse   415 --NSHLIQHERTHTGEKPYACSLCGAAFSQGSSLFKHQRVHT-GEKPFSCPHCGRAFSHSSNLTQ 476

  Fly   496 HIKTHEKEKPNVCDVCGKAFALKYVLTQHRLSHEVLEKNFKCNVCGRAYLFEKSLRLHQRTHTGK 560
            |...|..|:|..|..||||||...||..||..| ..||.|.|..||||:....:|..|||.|||:
Mouse   477 HQLLHTGERPFRCGDCGKAFAKGAVLLSHRRIH-TGEKPFVCTQCGRAFRERPALFHHQRIHTGE 540

  Fly   561 TYYKCDLCQERFVTH-------IKLKTHMQKAHAASQP 591
            .    .|.:.|..||       :.|.....||.:.:.|
Mouse   541 K----ALRRPRGSTHPQARSLGVSLDGAPPKASSTTAP 574

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071
		COG5048	198..>508	CDD:227381	67/309 (22%)
		C2H2 Zn finger	221..241	CDD:275368	5/19 (26%)
		C2H2 Zn finger	249..269	CDD:275368	6/19 (32%)
		C2H2 Zn finger	277..297	CDD:275368	7/19 (37%)
		C2H2 Zn finger	305..327	CDD:275368	0/21 (0%)
		C2H2 Zn finger	338..359	CDD:275368	8/20 (40%)
		C2H2 Zn finger	367..384	CDD:275368	4/16 (25%)
		C2H2 Zn finger	400..420	CDD:275368	2/19 (11%)
		C2H2 Zn finger	451..471	CDD:275368	6/19 (32%)
		C2H2 Zn finger	480..500	CDD:275368	6/19 (32%)
		C2H2 Zn finger	508..528	CDD:275368	11/19 (58%)
		C2H2 Zn finger	537..557	CDD:275368	9/19 (47%)
		C2H2 Zn finger	565..582	CDD:275368	5/23 (22%)
Zfp324	NP_848847.3	KRAB	31..91	CDD:214630
		KRAB	31..70	CDD:279668
		zf-C2H2	291..313	CDD:278523	5/21 (24%)
		C2H2 Zn finger	293..313	CDD:275368	5/19 (26%)
		COG5048	<297..497	CDD:227381	66/290 (23%)
		zf-H2C2_2	305..330	CDD:290200	7/24 (29%)
		C2H2 Zn finger	321..341	CDD:275368	6/19 (32%)
		zf-H2C2_2	333..358	CDD:290200	8/24 (33%)
		C2H2 Zn finger	349..369	CDD:275368	7/19 (37%)
		zf-H2C2_2	361..386	CDD:290200	11/57 (19%)
		C2H2 Zn finger	377..397	CDD:275368	8/20 (40%)
		zf-C2H2	403..425	CDD:278523	10/77 (13%)
		C2H2 Zn finger	405..425	CDD:275368	9/75 (12%)
		zf-H2C2_2	417..442	CDD:290200	5/24 (21%)
		C2H2 Zn finger	433..453	CDD:275368	6/19 (32%)
		zf-H2C2_2	445..470	CDD:290200	10/25 (40%)
		C2H2 Zn finger	461..481	CDD:275368	6/19 (32%)
		zf-H2C2_2	473..497	CDD:290200	9/23 (39%)
		C2H2 Zn finger	489..509	CDD:275368	11/19 (58%)
		zf-H2C2_2	502..524	CDD:290200	11/22 (50%)
		C2H2 Zn finger	517..537	CDD:275368	9/19 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100