DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8301 and Zfp128

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	NP_722497.1	Gene:	Zfp128 / 243833	MGIID:	2389445	Length:	572	Species:	Mus musculus

Alignment Length:	500	Identity:	120/500 - (24%)
Similarity:	177/500 - (35%)	Gaps:	162/500 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   109 LEPAEEHQETETTKPTTTVSAETQPNNTASDPI---EIFVDAV------DIDEAEEEEEE--EEQ 162
            ||| |:|         |.:..:..|....| ||   :.|..||      .||:..:.:.:  ::.
Mouse   100 LEP-EDH---------TLLKDQGLPKMEPS-PITEKDGFAKAVPCRSMIGIDQESDGQRQALKKD 153

  Fly   163 QQQYDEEVEEPITDESAPPQLTISYACKFCLRPQENYQLQQLLLEHI--------------NASH 213
            |...::..|.|:..:| ...|.:..||..        .|...||..|              |:.|
Mouse   154 QSNLNDPKEIPLQSQS-HKSLGLVEACVL--------GLNTYLLPDISGREYGCTYDSQVKNSEH 209

  Fly   214 DP---EQPYNCPECEARFQDAASR---------TVHLKSSHVEKQHACGVCGKKYGDRHNLRHHV 266
            :|   .|..:.|..:: |.|..|:         |...||...:|.:.|..|||.:  .||..
Mouse   210 NPSLVRQRTDSPATQS-FDDNGSQKAFDQIMPITELTKSQVQDKPYKCTDCGKSF--NHNAH--- 268

  Fly   267 EKYHSETDFECALCEKRFYTRKSLNYHMKWHNPDRQFKCRHSGCERLFISQRHLMCHEATHSGTS 331
                                   |..|.:.|..:|.:.|:.  |.:.|.....|:.||..|:|..
Mouse   269 -----------------------LTVHKRIHTGERPYMCKE--CGKAFSQNSSLVQHERIHTGDK 308

  Fly   332 SRKSEHCGFCGKTFIHLKTLRWHIYRQHGGEKPYKCANCTEVFASYAEKRIHMLERHRENLTAIE 396
            ..|   |..|||:|.|...|..| .|.|.|||||:|.:|...|...:.     |.||:...|.
Mouse   309 PYK---CDECGKSFCHSTHLTVH-RRIHTGEKPYECQDCGRAFNQNSS-----LGRHKRTHTG-- 362

  Fly   397 RSECMLCRQPFSSEPDLIHHMSAEHLQRPGAPIIANNKRVLQQKRERQYSGLFQCGSCSQRFNMK 461
                                                         |:.|:    |..|.:.|:..
Mouse   363 ---------------------------------------------EKPYT----CSVCGKSFSRT 378

  Fly   462 SALERHAAVHSEKDRPHACPHCSKRFKRAQDMKWHIKTHEKEKPNVCD---VCGKAFAL-KYVLT 522
            :.|..|...|:| :||:.|.||.|.|:.:..:..|.:.|..|||..|.   :..:|.|| ||..|
Mouse   379 TCLFLHLRTHTE-ERPYECNHCGKGFRHSSSLAQHQRKHAGEKPYECRQRLIFEQAPALIKYEWT 442

  Fly   523 Q-----HRLSH----EVLEKNFKCNVCGRAYLFEKSLRLHQRTHT 558
            :     ..||.    :..::.||||.||:.:.....|..||.||:
Mouse   443 EPLGCDSPLSQGERTQRSDRPFKCNQCGKCFTQSSHLIRHQLTHS 487

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071
		COG5048	198..>508	CDD:227381	78/335 (23%)
		C2H2 Zn finger	221..241	CDD:275368	6/28 (21%)
		C2H2 Zn finger	249..269	CDD:275368	6/19 (32%)
		C2H2 Zn finger	277..297	CDD:275368	2/19 (11%)
		C2H2 Zn finger	305..327	CDD:275368	6/21 (29%)
		C2H2 Zn finger	338..359	CDD:275368	9/20 (45%)
		C2H2 Zn finger	367..384	CDD:275368	3/16 (19%)
		C2H2 Zn finger	400..420	CDD:275368	0/19 (0%)
		C2H2 Zn finger	451..471	CDD:275368	5/19 (26%)
		C2H2 Zn finger	480..500	CDD:275368	6/19 (32%)
		C2H2 Zn finger	508..528	CDD:275368	8/28 (29%)
		C2H2 Zn finger	537..557	CDD:275368	7/19 (37%)
		C2H2 Zn finger	565..582	CDD:275368
Zfp128	NP_722497.1	KRAB	25..85	CDD:214630
		KRAB	25..64	CDD:279668
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	140..164		3/23 (13%)
		COG5048	<198..401	CDD:227381	67/294 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	205..231		7/26 (27%)
		zf-C2H2	254..276	CDD:278523	8/49 (16%)
		C2H2 Zn finger	256..276	CDD:275368	8/47 (17%)
		zf-H2C2_2	268..293	CDD:290200	7/52 (13%)
		C2H2 Zn finger	284..304	CDD:275368	6/21 (29%)
		zf-H2C2_2	296..319	CDD:290200	10/25 (40%)
		C2H2 Zn finger	312..332	CDD:275368	9/20 (45%)
		zf-H2C2_2	324..349	CDD:290200	12/25 (48%)
		C2H2 Zn finger	340..360	CDD:275368	6/24 (25%)
		zf-H2C2_2	352..377	CDD:290200	9/80 (11%)
		C2H2 Zn finger	368..388	CDD:275368	5/19 (26%)
		zf-C2H2	394..416	CDD:278523	6/21 (29%)
		C2H2 Zn finger	396..416	CDD:275368	6/19 (32%)
		zf-C2H2	464..486	CDD:278523	9/21 (43%)
		C2H2 Zn finger	466..486	CDD:275368	7/19 (37%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	483..529		3/4 (75%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100