DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8301 and Zfp775

DIOPT Version :9

Sequence 1:	NP_649915.1	Gene:	CG8301 / 41160	FlyBaseID:	FBgn0037717	Length:	607	Species:	Drosophila melanogaster
Sequence 2:	XP_036022003.1	Gene:	Zfp775 / 243372	MGIID:	2683557	Length:	556	Species:	Mus musculus

Alignment Length:	541	Identity:	123/541 - (22%)
Similarity:	174/541 - (32%)	Gaps:	179/541 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   152 EAEEEEEEEEQQQQ----------------YDEEVE----EPITDESAPPQLTISYACKFCLRPQ 196
            :|.|:::|...|||                ..||..    .|:.::.||....:.......|.|.
Mouse    50 QATEKDKENIFQQQSGLPPCQTMGRPRALGSQEETGGTRWAPLPEQDAPLAARVPGTAPGPLSPS 114

  Fly   197 ENYQLQQLLLEHINASHDPEQPYNCPECEARFQDAASRTVHLKSSHVEKQHACGVCGKKYGDRHN 261
            .:          ....|     :.|.:|..||...:|..:|.::...||.:.||.|||.:..:.|
Mouse   115 LS----------AGGGH-----FVCVDCGKRFSWWSSLKIHQRTHTGEKPYLCGKCGKSFSQKPN 164

  Fly   262 LRHHVEKYHSETDFECALCEKRFYTRKSLNYHMKWHNPDRQFKCRHSGCERLFISQRHLMCHEAT 326
            |..|...:..|..|.|..|.:||..::.|..|.|.|:......|..  |||.|..|..|..|:..
Mouse   165 LVRHQRHHTGERPFCCPECTRRFSQKQHLLKHQKTHSRPATHTCPE--CERCFRHQVGLRIHQRA 227

  Fly   327 HS------------------------------------------------------------GTS 331
            |:                                                            |.|
Mouse   228 HARNRLGARVNLHEMFRYAAARRWSCRLRPGSPRGHPEWVWLGLCRSWWGQHGVRTTAHSRLGPS 292

  Fly   332 SRKSEHCGFCGKTFIHLKTLRWHIYRQHGGEKPYKCANCTEVFASYAEKRIHMLERHRENLTAIE 396
            .::...|..|||:|....:|..| .|.|.||:||.|..|...|:....     |.||..|.|...
Mouse   293 EQRQFICNDCGKSFTWWSSLNIH-QRIHTGERPYACPECGRCFSQKPN-----LTRHLRNHTGER 351

  Fly   397 RSECMLCRQPFSSEPDLIHHMSAEHLQRPGAPIIANNKRVLQQKRERQYSGLFQCGSCSQRFNMK 461
            ...|..|.:.|..:..|:.|:.. ||  |||          |..|         |.||.|....:
Mouse   352 PHPCSHCGRSFRQKQHLLKHLRT-HL--PGA----------QAAR---------CTSCGQSCPSR 394

  Fly   462 SALERHAAVHS-----------------------------------------------------E 473
            :||..|..||:                                                     .
Mouse   395 AALRAHQRVHTAAELLRSQSAVRDGVPGSESQAEIAQSVVVKPQGPQGAKEVLCGQECETLAVPS 459

  Fly   474 KDRPHACPHCSKRFKRAQDMKWHIKTHEKEKPNVCDVCGKAFALKYVLTQHRLSHEVLEKNFKCN 538
            :.|...|..|.|.|.....:..|.:.|..|:|..|..||:.|:.|..||:||.:| ..|:.:.|.
Mouse   460 EQRQFICNECGKSFSWWSALTIHQRIHTGERPYACPDCGRCFSQKPNLTRHRRNH-TGERPYLCT 523

  Fly   539 VCGRAYLFEKSLRLHQRTHTG 559
            .|||.:..::.|..|||.|.|
Mouse   524 ACGRGFRQKQHLLKHQRVHRG 544

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8301	NP_649915.1	zf-AD	3..87	CDD:285071
		COG5048	198..>508	CDD:227381	89/422 (21%)
		C2H2 Zn finger	221..241	CDD:275368	6/19 (32%)
		C2H2 Zn finger	249..269	CDD:275368	8/19 (42%)
		C2H2 Zn finger	277..297	CDD:275368	7/19 (37%)
		C2H2 Zn finger	305..327	CDD:275368	8/21 (38%)
		C2H2 Zn finger	338..359	CDD:275368	8/20 (40%)
		C2H2 Zn finger	367..384	CDD:275368	3/16 (19%)
		C2H2 Zn finger	400..420	CDD:275368	5/19 (26%)
		C2H2 Zn finger	451..471	CDD:275368	7/19 (37%)
		C2H2 Zn finger	480..500	CDD:275368	5/19 (26%)
		C2H2 Zn finger	508..528	CDD:275368	9/19 (47%)
		C2H2 Zn finger	537..557	CDD:275368	8/19 (42%)
		C2H2 Zn finger	565..582	CDD:275368
Zfp775	XP_036022003.1	C2H2 Zn finger	124..144	CDD:275368	6/19 (32%)
		COG5048	<148..233	CDD:227381	28/86 (33%)
		C2H2 Zn finger	152..172	CDD:275368	8/19 (42%)
		C2H2 Zn finger	180..200	CDD:275368	7/19 (37%)
		C2H2 Zn finger	208..228	CDD:275368	8/21 (38%)
		C2H2 Zn finger	299..319	CDD:275368	8/20 (40%)
		COG5048	323..>371	CDD:227381	14/52 (27%)
		C2H2 Zn finger	327..347	CDD:275368	6/24 (25%)
		C2H2 Zn finger	355..375	CDD:275368	5/20 (25%)
		C2H2 Zn finger	384..404	CDD:275368	7/19 (37%)
		C2H2 Zn finger	466..486	CDD:275368	5/19 (26%)
		COG5048	490..>547	CDD:227381	22/56 (39%)
		C2H2 Zn finger	494..514	CDD:275368	9/19 (47%)
		C2H2 Zn finger	522..542	CDD:275368	8/19 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24377
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100